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Comparison of exercise, dipyridamole, adenosine, and dobutamine stress with the use of Tc-99m tetrofosmin tomographic imaging

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Journal of Nuclear Cardiology Aims and scope

Abstract

Purpose

The purpose of this study was to compare defect extent and severity and myocardial uptake with exercise and pharmacologic stress with technetium-99m (Tc-99m) tetrofosmin tomographic myocardial perfusion imaging

Background

Detection of stress-induced myocardial perfusion defects depends on both a disparity in blood flow between normal and stenotic vessels and the extraction fraction and linearity of myocardial uptake of the tracer. There are limited clinical data for exercise or pharmacologic stress with Tc-99m tetrofosmin tomographic myocardial perfusion imaging.

Methods

Thirty-one patients with coronary artery disease and 7 with a<5% likelihood of coronary artery disease underwent on separate days Tc-99m tetrofosmin single-photon emission computed tomographic imaging at rest and after exercise, dipyridamole, adenosine, and dobutamine stress. Images were interpreted by a blinded consensus of 3 experienced readers with a 17-segment model and 5-point scoring system.

Results

Compared with exercise, the summed stress score was smaller with dipyridamole (p<.01), and the reversibility score was smaller with both dipyridamole (P<.01) and dobutamine (P<.05), whereas the number of abnormal and reversible segments was less with both dipyridamole (P<.01 and P<.001, respectively) and dobutamine (both P<.05). No significant differences were found in the summed stress or reversibility scores and the number of abnormal or reversible segments between exercise and adenosine.

Conclusions

Compared with exercise, defect extent, severity, and reversibility are less with dipyridamole and dobutamine with Tc-99m tetrofosmin single photon emission computed tomographic imaging.

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Authors and Affiliations

  1. Nuclear Cardiology Laboratory, Division of Cardiology, Hartford Hospital, 80 Seymour St, 06102-5037, Hartford, CT

    Michael G. Levine, Alan W. Ahlberg, April Mann, Michael P. White, Carol C. McGill, Jose M. Piriz, David Waters & Gary V. Heller

  2. Divisions of Medicine and Diagnostic Imaging and Therapeutics, Rush Institute for Healthy Aging, Chicago, Ill.

    Carlos Mendes de Leon & Gary V. Heller

  3. University of Connecticut School of Medicine, Farmington, Conn.

    David Waters

Authors
  1. Michael G. Levine
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  2. Alan W. Ahlberg
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  3. April Mann
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  4. Michael P. White
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  5. Carol C. McGill
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  6. Carlos Mendes de Leon
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  7. Jose M. Piriz
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  8. David Waters
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  9. Gary V. Heller
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Corresponding author

Correspondence to Gary V. Heller.

Additional information

Supported in part by a grant from Nycomed-Amersham, Inc, Arlington Heights, III., and Hartford Hospital, Hartford, Conn.

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Levine, M.G., Ahlberg, A.W., Mann, A. et al. Comparison of exercise, dipyridamole, adenosine, and dobutamine stress with the use of Tc-99m tetrofosmin tomographic imaging. J Nucl Cardiol 6, 389–396 (1999). https://doi.org/10.1016/S1071-3581(99)90004-1

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  • DOI: https://doi.org/10.1016/S1071-3581(99)90004-1

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