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Diagnostic value of stress thallium-201/rest technetium-99m-sestamibi sequential dual isotope high-speed myocardial perfusion imaging for the detection of haemodynamically relevant coronary artery stenosis

  • Original Article
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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

The aim of this study was to determine the diagnostic accuracy of stress thallium-201/rest technetium-99m-sestamibi sequential dual-isotope high-speed myocardial perfusion imaging (DI-HS-MPI) against invasively determined fractional flow reserve (FFR).

Methods

Fifty-four consecutive patients prospectively underwent DI-HS-MPI before invasive coronary angiography. Perfusion was scored visually by summed stress score on a patient and coronary territory basis. Significant coronary artery disease (CAD) was defined by the presence of ≥ 90% stenosis/occlusion or fractional flow reserve ≤ 0.80 for coronary stenosis ≥ 50%.

Results

FFR was measured in 69 of 162 coronary vessels, with 1.28 ± 0.56 vessels assessed/patient. Sensitivity, specificity, and diagnostic accuracy of MPI for the detection of significant CAD were 92.8%, 69.2%, and 81.4%, on a patient basis, and 83.7%, 90.4%, and 88.8% by coronary territory.

Conclusions

DI-HS-MPI accurately detects functionally significant CAD as defined by using FFR.

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Abbreviations

CZT:

Cadmium-Zinc-Telluride

DI-HS-MPI:

Stress thallium-201/rest technetium-99m-MIBI sequential dual-isotope high-speed myocardial perfusion imaging

FFR:

Fractional flow reserve

ICA:

Invasive coronary angiography

MPI:

Myocardial perfusion imaging

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Authors and Affiliations

  1. Department of Cardiology, University Hospital, Grenoble Alpes, France

    Gilles Barone-Rochette MD, PhD, Feras Zoreka MD, Nicolas Piliero MSc, Jacques Machecourt MD, PhD & Gerald Vanzetto MD, PhD

  2. INSERM U1039, Bioclinic Radiopharmaceutics Laboratory, Grenoble Alpes, France

    Gilles Barone-Rochette MD, PhD, Alexis Broisat PhD, Laurent Riou PhD, Daniel Fagret MD, PhD, Gerald Vanzetto MD, PhD & Catherine Ghezzi PhD

  3. French Alliance Clinical Trial, French Clinical Research Infrastructure Network, Paris, France

    Gilles Barone-Rochette MD, PhD & Gerald Vanzetto MD, PhD

  4. Department of Nuclear medicine, University Hospital, Grenoble Alpes, France

    Loïc Djaileb MD, Alex Calizzano MD & Daniel Fagret MD, PhD

  5. Center of Clinical Investigations, Grenoble Alpes University Hospital, Grenoble, France

    Jean Louis Quesada MSc

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  1. Gilles Barone-Rochette MD, PhD
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  2. Feras Zoreka MD
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Correspondence to Gilles Barone-Rochette MD, PhD.

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Barone-Rochette, G., Zoreka, F., Djaileb, L. et al. Diagnostic value of stress thallium-201/rest technetium-99m-sestamibi sequential dual isotope high-speed myocardial perfusion imaging for the detection of haemodynamically relevant coronary artery stenosis. J. Nucl. Cardiol. 26, 1269–1279 (2019). https://doi.org/10.1007/s12350-018-1189-8

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