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Application of an integrated matrix-assisted laser desorption/ionization time-of-flight, electrospray ionization mass spectrometry and tandem mass spectrometry approach to characterizing complex polyol mixtures

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Journal of the American Society for Mass Spectrometry

Abstract

Polyols are being used in a wide range of industrial applications including surfactants and precursors for grafted polymers. The characterization of polyols is of significance in correlating compositions and structures with their properties. We illustrate two real world examples where traditional analytical methods including GPC and NMR failed to reveal compositional differences, but the combination of matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF), electrospray ionization mass spectrometry (ESI MS), and MS/MS can produce compositional information required for problem solving. The first example involves failure analysis of four ethylene oxide and propylene oxide (EO/PO) copolymer products. The results from the mass spectrometry analysis unequivocally demonstrate that one of the samples has a small variation in copolymer composition, leading to its abnormal activity. The second example is in the area of deformulation of complex polyol mixtures. Two samples displaying similar properties and activities were found to be two different polyol blends. One of the samples is a more cost-effective product. These examples demonstrate that MALDI, ESI MS, and MS/MS should be seriously considered as an integrated component of an overall polyol characterization program in product failure analysis and deformulation.

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References

  1. Bahr, U.; Deppe, A.; Karas, M.; Hillenkamp, F.; Giessman, U.Anal. Chem. 1992,64, 2866.

    Article  CAS  Google Scholar 

  2. Danis, P. O.; Karr, D. E.; Mayer, F.; Holle, A.; Watson, C. H.Org. Mass Spectrom. 1992,27, 843.

    Article  CAS  Google Scholar 

  3. Danis, P. O.; Karr, D. E.Org. Mass Spectrom. 1993,28, 923.

    Article  CAS  Google Scholar 

  4. Juhasz, P.; Costello, C. E.Rapid Commun. Mass Spectrom. 1993,7, 343.

    Article  CAS  Google Scholar 

  5. Prokai, L.; Simonsick, W. J., Jr.Rapid Commun. Mass Spectrom. 1993,7, 853.

    Article  CAS  Google Scholar 

  6. Montaudo, G.; Montaudo, M. S.; Puglisi, C.; Samperi, F.Macromolecules 1995,28, 4562.

    Article  CAS  Google Scholar 

  7. Dey, M.; Castoro, J. A.; Wilkins, C. L.Anal. Chem. 1995,67, 1575.

    Article  CAS  Google Scholar 

  8. Blais, J. C.; Tessier, M.; Bolbach, G.; Remaud, B.; Rozes, L.; Guittard, J.; Brunot, A.; Marechal, E.; Talet, J. C.Int. J. Mass Spectrom. Ion Processes 1995,144, 131.

    Article  CAS  Google Scholar 

  9. Weidner, S.; Kuhn, G.; Just, U.Rapid Commun. Mass Spectrom. 1995,9, 697.

    Article  CAS  Google Scholar 

  10. Jackson, A. T.; Yates, H. T.; Scrivens, J. H.; Critchley, G.; Brown, J.; Green, M.R.; Bateman, R. H.Rapid Commun. Mass Spectrom. 1996,10, 1668.

    Article  CAS  Google Scholar 

  11. Fei, X.; Murray, K. K.Anal. Chem. 1996,68, 3555.

    Article  CAS  Google Scholar 

  12. Whittal, R. M.; Schreimer, D. C.; Li, L.Anal. Chem. 1997,69, 2734.

    Article  CAS  Google Scholar 

  13. O’Connor, P. B.; Duursma, M. C.; van Rooij, G. J.; Heeren, R. M. A.; Boon, J. J.Anal. Chem. 1997,69, 2751.

    Article  Google Scholar 

  14. Hensel, R. R.; King, R. C.; Owens, K. G.Rapid Commun. Mass Spectrom. 1997,11, 1785.

    Article  CAS  Google Scholar 

  15. Parees, D. M.; Hanton, S. D.; Cornelio Clark, P. A.; Willcox, D. A.J. Am. Soc. Mass Spectrom. 1998,9, 282.

    Article  CAS  Google Scholar 

  16. Pastor, S. J.; Wilkins, C. L.Int. J. Mass Spectrom. Ion Processes 1998,175, 81.

    Article  CAS  Google Scholar 

  17. Pasch, H.Phys. Chem. Chem. Phys. 1999,1, 3879.

    Article  CAS  Google Scholar 

  18. Rashidzadeh, H.; Wang, Y.; Guo, B. C.Rapid Commun. Mass Spectrom. 2000,14, 439.

    Article  CAS  Google Scholar 

  19. Wong, S. F.; Meng, C. K.; Fenn, J. B.J. Phys. Chem. 1988,92, 546.

    Article  CAS  Google Scholar 

  20. Takashi, N.; Fenn, J. B.J. Am. Chem. Soc. 1992,114, 3241.

    Article  Google Scholar 

  21. O’Connor, P. B.; McLafferty, F. W.J. Am. Chem. Soc. 1995,117, 12826.

    Article  Google Scholar 

  22. Hunt, S. M.; Sheil, M. M.; Belov, M.; Derrick, P. J.Anal. Chem. 1998,70, 1812.

    Article  CAS  Google Scholar 

  23. Maziarz, E. P.; Baker, G. A.; Lorenz, S. A.; Wood, T. D.J. Am. Soc. Mass Spectrom. 1999,10, 1298.

    Article  CAS  Google Scholar 

  24. Guo, X. H.; Fokkens, R. H.; Peeters, H. J. W.; Nibbering, N. M. M.; de Koster, C. G.Rapid Commun. Mass Spectrom. 1999,13, 2223.

    Article  CAS  Google Scholar 

  25. Whittal, R. M.; Li, L.; Lee, S.; Winnik, M. A.Macromol. Rapid Commun. 1996,17, 59.

    Article  CAS  Google Scholar 

  26. Lee, S.; Winnik, M. A.; Whittal, R. M.; Li, L.Macromolecules 1996,29, 3060.

    Article  CAS  Google Scholar 

  27. Watson, E.; Shah, B.; DePrince, R.; Hendren, R. W.; Nelson, R.BioTechnique 1994,16, 278.

    CAS  Google Scholar 

  28. Weidner, S.; Kuhn, G.Rapid Commun. Mass Spectrom. 1996,10, 942.

    Article  CAS  Google Scholar 

  29. Bullock, J.; Chowdhury, S.; Johnston, D.Anal. Chem. 1996,68, 3258.

    Article  CAS  Google Scholar 

  30. Barry, J. P.; Carton, W. J.; Pesci, K. M.; Anselmo, R. T.; Radtke, D. R.; Evans, J. V.Rapid Commun. Mass Spectrom. 1997,11, 437.

    Article  CAS  Google Scholar 

  31. Sauvagnat, B.; Enjalbal, C.; Lamaty, F.; Lazaro, R.; Martinez, J.; Aubagnac, J.-L.Rapid Commun. Mass Spectrom. 1998,12, 1034.

    Article  CAS  Google Scholar 

  32. Enjalbal, C.; Sauvagnat, B.; Lamaty, F.; Lazaro, R.; Martinez, J.; Mouchet, P.; Roux, F.; Aubagnac, J.-L.Rapid Commun. Mass Spectrom. 1999,13, 1775.

    Article  CAS  Google Scholar 

  33. Barton, Z.; Kemp, T. J.; Buzy, A.; Jennings, K. R.Polymer 1995,36, 4927.

    Article  CAS  Google Scholar 

  34. Lattimer, R. P. InProceedings of the 47th ASMS Conference on Mass Spectrometry and Allied Topics; Dallas, TX, June 13–17, 1999; Paper 175.

  35. Sherrard, K. B.; Marrlott, P. J.; McCormick, M. J.; Colton, R.; Smith, G.Anal. Chem. 1994,66, 3394.

    Article  CAS  Google Scholar 

  36. Crescenzi, C.; Di Corcia, A.; Samperi, R.; Marcomini, A.Anal. Chem. 1995,67, 1797.

    Article  CAS  Google Scholar 

  37. Ogura, I.; DuVal, D. L.; Kawakami, S.; Miyajima, K.J. Am. Oil Chem. Soc. 1996,73, 137.

    Article  CAS  Google Scholar 

  38. Cumme, G. A.; Blume, E.; Bublitz, R.; Hoppe, H.; Horn, A.J. Chromatogr. A 1997,791, 245.

    Article  Google Scholar 

  39. Crowther, M. W.; O’Connell, T. R.; Carter, S. P.J. Am. Oil Chem. Soc. 1998,75, 1867.

    Article  CAS  Google Scholar 

  40. Van Rooij, G. J.; Duursma, M. C.; de Koster, C. G.; Heeren, R. M. A.; Boon, J. J.; Wijnand Schuyl, P. J.; van der Hage, E. R. E.Anal. Chem. 1998,70, 843.

    Article  Google Scholar 

  41. Willetts, M.; Clench, M. R.; Greenwood, R.; Mills, G.; Carolan, V.Rapid Commun. Mass Spectrom. 1999,13, 251.

    Article  CAS  Google Scholar 

  42. Castillo, M.; Alonso, M. C.; Riu, J.; Barcelo, D.Environ. Sci. Technol. 1999,33, 1300.

    Article  CAS  Google Scholar 

  43. Nuwaysir, L. M.; Wilkins, C. L.; Simonsick, W. J., Jr.J. Am. Soc. Mass Spectrom. 1990,1, 66.

    Article  CAS  Google Scholar 

  44. Whittal, R. M.; Li, L.Anal. Chem. 1995,67, 1950.

    Article  CAS  Google Scholar 

  45. Mahon, A.; Kemp, T. J.; Buzy, A.; Jennings, K. R.Polymer 1996,37, 531.

    Article  CAS  Google Scholar 

  46. Selby, T. L.; Wesdemiotis, C.; Lattimer, R. P.J. Am. Soc. Mass Spectrom. 1994,5, 1081.

    Article  CAS  Google Scholar 

  47. Lattimer, R. P.J. Am. Soc. Mass Spectrom. 1992,3, 225.

    Article  CAS  Google Scholar 

  48. Rui, C.; Li, L., unpublished.

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Authors and Affiliations

  1. Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada

    Rui Chen & Liang Li

  2. Nalco Chemical Company, Naperville, Illinois, USA

    Amy M. Tseng & Mary Uhing

Authors
  1. Rui Chen
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  2. Amy M. Tseng
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  3. Mary Uhing
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  4. Liang Li
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Correspondence to Liang Li.

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Chen, R., Tseng, A.M., Uhing, M. et al. Application of an integrated matrix-assisted laser desorption/ionization time-of-flight, electrospray ionization mass spectrometry and tandem mass spectrometry approach to characterizing complex polyol mixtures. J. Am. Soc. Spectrom. 12, 55–60 (2001). https://doi.org/10.1016/S1044-0305(00)00200-2

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  • DOI: https://doi.org/10.1016/S1044-0305(00)00200-2

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