Abstract
Two matrices, 4-phenyl-α-eyanocinnamic acid (PCC) and 4-benzyloxy-α-eyanocinnamic acid (BCC), were identified for the determination of polycyclic aromatic hydrocarbon (PAH) adducts of DNA bases by matrix-assisted laser desorption ionization. These matrices were designed based on the concept that the matrix and the analyte should have structural similarities. PCC is a good matrix for the desorption of not only PAH-modified DNA bases, but also PAHs themselves and their metabolites. Detections can be made at the femtomolar level.
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George, M., Wellemans, J.M.Y., Cerny, R.L. et al. Matrix design for matrix-assisted laser desorption ionization: Sensitive determination of PAH-DNA adducts. J Am Soc Mass Spectrom 5, 1021–1025 (1994). https://doi.org/10.1016/1044-0305(94)80021-9
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DOI: https://doi.org/10.1016/1044-0305(94)80021-9