Abstract
Spectroscopy Laboratory, The Dow Chemical Company, Midland, Michigan, USA In December 1955 or thereabouts, the authors coupled a homemade gas chromatograph to a research time-of-flight mass spectrometer constructed by W. C. Wiley, I. H. McLaren, and D. B. Harrington. This unique gas chromatography/mass spectrometry (GC/MS) instrument generated mass spectra at a lo-kHz rate for display on an oscilloscope; eluted gas chromate graphic components, such as methanol, acetone, benzene, toluene, and carbon tetrachloride, could be visually identified immediately from the oscilloscope display. Many years of further research and development in many laboratories worldwide were necessary, however, to make continuous on-line GC/MS the uniquely valuable analytical tool that it is today.
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O’Neal, M. J. Jr.; Wier, T. P. Anal. Chem. 1951, 23, 830–843.
Brown, R. A.; Melpolder, F. W.; Young, W. S. Pet. Process. 1952, 7, 204.
Dibeler, V. H. Anal. Chem. 1954, 26 58–65.
Rock, S. M. Anal. Chem. 1951, 23, 261–268.
Happ, G. P.; Stewart, D. W. J. Am. Chem. Soc. 1952, 74, 4404–4408.
Long, F. A.; Friedman, L. J. Am. Chem. Soc. 1953, 75, 2832–2836; 2837–2840.
Momigny, J. Bull. Soc. Roy. Sci. Liege 1953, 22, 541.
Nicholson, A. J. C. Trans. Faraday Soc. 1954, 50, 1067.
Beynon, J. H. Nature 1954, 174, 735.
Sharkey, A. C. Jr.; Schultz, J. L.; Friedel, R. A. Anal. Chem. 1956, 28, 934–944.
DeMayo, P.; Reed, R. I. Chem. Ind. (London) 1956, 1481.
Baker, A. W.; Wright, N.; Opler, A. Anal. Chem. 1953, 25, 1457–1460.
Caldecourt, V. J. Anal. Chem. 1955, 27, 1670.
McLafferty, F. W.; Gohlke, R. S. ASTM Committee E-14, Conference of Mass Spectrometry; New Orleans, LA, May 1954.
McLafferty, F. W. Anal. Chem. 1956, 28, 306–316
Gohlke, R. S. Anal. Chem. 1957, 29, 1723–1724.
McLafferty, F. W. Appl. Spectrosc. 1957, 11, 148–156.
DalNogare, S.; Wilson, H. N. Gordon Research Conference, August 1954, private communication.
James, A. T.; Martin, A. J. P. Biochem. J. 1952, 50, 679.
Drew, C. M.; Smith, S. R. ASTM E-14 Meeting on Mass Spectrometry; San Francisco, CA, May 1955; p 36.
Beynon, J. H.; Saunders, R. A.; Williams, A. E. J. Sci. Instrum. 1959, 36, 375.
Wiley, W. C.; McLaren, I. H. Rev. Sci. Instrum. 1955, 26, 1150–1157.
Wiley, W. C. Science 1956, 124, 817–820.
Holmes, J. C.; Morrell, F. A. Appl. Spectrosc. 1957, 2, 86–87.
Gohlke, R. S.; McLafferty, F. W. Presented at the Symposium on Vapor Phase Chromatography, 129th ACS Meeting, Dallas, TX, April 1956.
Gohlke, R. S. Anal. Chem. 1959, 31, 535–541.
Wiley, W. C., personal communication, June 29, 1992.
McLafferty, F. W.; Gohlke, R. S. Anal. Chem. 1959, 31, 1160–1163.
(a) Dutton, H. J., personal communications, April 8 and 21, 1992; (b) Dutton, H. J. J. Am. Oil Chem. Soc. 1961, 38, 660–664.
Linderman, L. P.; Annis, J. L. Anal. Chem. 1960, 32, 1742–1749.
Ebert, A. A. Anal. Chem. 1961, 33, 1865.
Gohlke, R. S. Anal. Chem. 1962, 34, 1332.
Venkataraghavan, R.; McLafferty, F. W. CHEMTECH 1972, 364.
McFadden, W. Techniques of Combined Gas Chromatography/ Mass Spectrometry; New York: Wiley, 1973.
McLafferty, F. W.; Michnowicz, J. CHEMTECH 1992, 22, 182–189.
McLafferty, F. W.; Loh, S. Y.; Stauffer, D. B. In Computer Enhanced Analytical Spectroscopy, Vol. II; Meuzelaar, H. C. L., Ed.; Plenum: New York, 1990; pp 163–181.
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Gohlke, R.S., McLafferty, F.W. Early gas chromatography/mass spectrometry. J Am Soc Mass Spectrom 4, 367–371 (1993). https://doi.org/10.1016/1044-0305(93)85001-E
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DOI: https://doi.org/10.1016/1044-0305(93)85001-E