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An overview of biochemical technologies for the cancer biomarker miR-21 detection

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Abstract

In recent years, the incidence of cancer has continuously increased, in which various miRNAs have been proposed as biomarkers for the early screening of cancer patients. As a consequence, the development of accurate methods for miRNA quantification has become a major research challenge worldwide. As one of the first discovered oncogenic miRNAs, microRNA-21 (miR-21) has been highlighted for its critical role in cancers. This review describes the main techniques currently available for miR-21 detection, compares the differences of the methods and the amplification strategies, and provides an overview of the state of knowledge in the field.

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Fig. 1

(Reprint from Ref. [47] with permission from the American Chemical Society. Copyright 2019)

Fig. 2

(Reprint from Ref. [78] with permission from the American Chemical Society. Copyright 2016)

Fig. 3

(Reprint from Ref. [81] with permission from the American Chemical Society. Copyright 2015)

Fig. 4

(Reprint from Ref. [28] with permission from the American Chemical Society. Copyright 2014)

Fig. 5

(Reprint from Ref. [96] with permission from the Author. Copyright 2018)

Fig. 6

(Reprint from Ref. [102]  with permission from the American Chemical Society. Copyright 2016)

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Data sharing is not applicable to this article as no new data were created or analyzed in this study.

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Acknowledgements

This study was financially supported by the Zhejiang Provincial Natural Science Foundation of China (LY18C100002) and National Natural Science Foundation of China (31400797).

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  1. College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou, 310018, China

    Buyun Wei, Biao Huang & Xueqin Zhao

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Wei, B., Huang, B. & Zhao, X. An overview of biochemical technologies for the cancer biomarker miR-21 detection. ANAL. SCI. 39, 815–827 (2023). https://doi.org/10.1007/s44211-023-00304-w

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