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Origami-Kirigami Structures and Its Applications in Biomedical Devices

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Abstract

Biological structures, spanning the spectrum from cells to multicellular organisms, organs, and the human body, exhibit exquisite hierarchical precision in three dimensions. Modern biomedicine necessitates precise detection and manipulation on the surfaces of organisms with complex morphology. The assembly of medical devices into three-dimensional structures requires a complex design and preparation process. Origami and Kirigami, rooted in historical craftsmanship, provide a viable solution to the challenges posed by the intricate world of biomedical engineering. Through simple geometric design, these traditional arts can impart novel mechanical properties, including but not limited to precise 3D deformation, hyper-stretching capabilities, and the creation of multistable structures. Origami and Kirigami designs present innovative opportunities for the high-volume assembly of 3D bio-integrated systems. This review aims to summarize and highlight the advantages offered by Origami and Kirigami design in biomedical engineering. Specifically, we will delve into their applications in diverse areas such as biosensing, scaffolds, medical instruments, and bioassembly. By elucidating these applications, we intend to underscore the versatility and transformative potential these traditional arts bring to the forefront of cutting-edge biomedical technologies. Lastly, we will discuss the challenges and future perspectives of origami and Kirigami design.

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Fig. 1

Copyright 2018 Wiley. Microfluidics. Microfluidics. Reprinted with permission from Ref. [16]. Copyright 2014 ACS Publication. Cell Culture Stents. Reprinted with permission from Ref. [17]. Copyright 2023 Springer Nature. Bone stents. Reprinted with permission from Ref. [18]. Copyright 2020 Elsevier. Manipulators. Reprinted with permission from Ref. [19]. Copyright 2020 Springer Nature. Robots. Reprinted with permission from Ref. [20]. Copyright 2022 Springer Nature. DNA Origami. Reprinted with permission from Ref. [21]. Copyright 2006 Springer Nature. Molecular Origami. Reprinted with permission from Ref. [22]. Copyright 2018 AAAS

Fig. 2

Copyright 2018 Wiley. b A 3D clamp platform that gently wraps and mechanically constrains organoids in ways that facilitate mechanical evaluations without damage. Reprinted with permission from Ref. [38]. Copyright 2021 Wiley. c FET probe that can be inserted into a single cell. Reprinted with permission from Ref. [43]. Copyright 2010 AAAS d Strain-insensitive graphene-based stretchable electrode with a Kirigami structure. Reprinted with permission from Ref. [44]. Copyright 2020 Elsevier

Fig. 3

Copyright 2011 ACS Publication. b Capillary force-assembly microfluidic device. Reprinted with permission from Ref. [49]. Copyright 2017 Wiley

Fig. 4

Copyright 2023 Springer Nature. b Bilayer hydrogel system for the simultaneous cultivation of epithelial and fibroblast cells. Reprinted with permission from Ref. [56]. Copyright 2023 Wiley. c Origami stent. Reprinted with permission from Ref. [57]. Copyright 2006 Elsevier. d The Bioadhesive patch folded into a triangular sleeve and then adhered the patch to the inside of the trachea and esophagus in conjunction with a balloon catheter. Reprinted with permission from Ref. [58]. Copyright 2021 Wiley e Bone scaffolds. Reprinted with permission from Ref. [60]. Copyright 2018 RSC publishing. f Multistable bone scaffold using a Kirigami structure. Reprinted with permission from Ref. [18]. Copyright 2020 Elsevier

Fig. 5

Copyright 2015 ACS Publication. b A folding nanoinjector for injection into mouse zygotes. Reprinted with permission from Ref.[19]. Copyright 2020 Springer Nature. c magnetically driven amphibious origami micro-robot based on origami design. Reprinted with permission from Ref. [20]. Copyright 2022 Springer Nature. d soft manipulators. Reprinted with permission from Ref. [68]. Copyright 2023 Springer Nature

Fig. 6

Copyright 2006 Springer Nature. c A DNA box. Reprinted with permission from Ref.[72]. Copyright 2009 Springer Nature. d A three-dimensional DNA spherical shell. Reprinted with permission from Ref. [73]. Copyright 2011 AAAS. e A clamp using DNA origami to test molecular force. Reprinted with permission from Ref. [75]. Copyright 2016 AAAS. f The motor consists of two rigid DNA origami arms. Reprinted with permission from Ref. [76]. Copyright 2023 Springer Nature. g Synthesizing DNA nanoshells on cell membranes. Reprinted with permission from Ref. [78]. Copyright 2023 ACS Publication. h A glycan hairpin. Reprinted with permission from Ref. [80]. Copyright 2023 Springer Nature

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Acknowledgements

This work was supported by the National Key Research and Development Program of China under Grant No. 2021YFA1401103; The National Science Fund for Distinguished Young Scholars under Grant No. 61825403; The National Natural Science Foundation of China under Grants No. 61921005 and 61674078.

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Authors and Affiliations

  1. Collaborative Innovation Center of Advanced Microstructures, School of Electronic Science and Engineering, Nanjing University, Nanjing, 210093, China

    Jing Wu, Xin Guo, Jiangbo Hua, Sheng Li, Lijia Pan & Yi Shi

  2. Nanjing Zijin Hospital, Nanjing, 211112, China

    Xingming Pan

  3. Traditional Chinese Medicine Department, BenQ Hospital, Nanjing, 210000, China

    Yuanyuan Cen

  4. Cardiac Surgery Department, Nanjing First Hospital, Nanjing, 210008, China

    Fuhua Huang

  5. Cardiology Department, Nanjing First Hospital, Nanjing, 210008, China

    Fengfu Zhang

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  1. Jing Wu
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Correspondence to Xingming Pan or Lijia Pan.

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Wu, J., Guo, X., Pan, X. et al. Origami-Kirigami Structures and Its Applications in Biomedical Devices. Biomedical Materials & Devices (2024). https://doi.org/10.1007/s44174-024-00168-2

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