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Multifunctional Redox and Temperature-Sensitive Drug Delivery Devices

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Abstract

Despite recent advances in drug delivery systems and tissue engineering, several challenges still need to be overcome for these new technologies to reach patients. The number of new cancer cases is increasing yearly, and the future projection is frightening. Another major health concern is the rise of antibiotic-resistant bacteria. The uncontrolled and excessive use of antibiotics has allowed bacteria to undergo mutation processes, decreasing the efficiency of this sort of drug. Therefore, the development of new medical devices is a battle against time to prevent projections on the advancement of diseases from being reached. Given this scenario, redox-sensitive and temperature-sensitive drug delivery platforms show promising results in the release of bioactive molecules. This review covers the most recent advances involving devices obtained from inorganic and polymeric matrices and their structuring as scaffolds and 3D printing, focusing on their potentiality of redox and temperature sensitivity for biomedical applications.

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All data are provided with paper.

Abbreviations

AMF:

Alternating magnetic field

DOX:

Doxorubicin

FRET:

Fluorescence resonance energy transfer

GSH:

Glutathione

LCST:

Lower critical solubility temperature

MFH:

Fluid hyperthermia

MOFs:

Metal–organic frameworks

MRI:

Magnetic resonance imaging

MWCNTs:

Multi-walled carbon nanotubes

NIR:

Near-infrared

NPs:

Nanoparticles

PCL:

Polycaprolactam

PDT:

Photodynamic therapy

PEG:

Polyethyleneglycol

PNIPAAm:

Poly(isopropylacrylamide)

PTT:

Photothermal therapy

PVCL:

Polyvinyl caprolactam

QDs:

Quantum dots

ROS:

Reactive oxygen species

SPION:

Superparamagnetic iron oxide nanoparticles

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Acknowledgements

The authors thank the financial support of the Brazilian agencies São Paulo State Research Foundation (FAPESP), Coordination for Higher Education Personnel Improvement (CAPES), Financing Studies and Projects (FINEP), and National Council of Technological and Scientific Development (CNPq).

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Authors and Affiliations

  1. Laboratory of Magnetic Materials and Colloids, Department of Analytical Chemistry, Physical Chemistry and Inorganic, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, 14800-060, Brazil

    Rodolfo Debone Piazza, Caio Carvalho dos Santos, Miguel Jafelicci Junior & Rodrigo Fernando Costa Marques

  2. Aveiro Institute of Materials - CICECO, University of Aveiro, Aveiro, Portugal

    Gabriel Cardoso Pinto

  3. Federal Institute of Education, Science and Technology of Tocantins (IFTO), Paraíso do Tocantins, TO, 77600-000, Brazil

    Guilherme Nunes Lucena

  4. Center for Monitoring and Research of the Quality of Fuels, Biofuels, Crude Oil and Derivatives – CEMPEQC (UNESP), Araraquara, Brazil

    Rodrigo Fernando Costa Marques

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  1. Rodolfo Debone Piazza
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Piazza, R.D., dos Santos, C.C., Pinto, G.C. et al. Multifunctional Redox and Temperature-Sensitive Drug Delivery Devices. Biomedical Materials & Devices 2, 191–207 (2024). https://doi.org/10.1007/s44174-023-00101-z

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