Abstract
Intraductal papillomas (IDPs), including central papilloma and peripheral papilloma, are common in the female population. Due to the lack of specific clinical manifestations of IDPs, it is easy to misdiagnose or miss diagnose. The difficulty of differential diagnosis using imaging techniques also contributes to these conditions. Histopathology is the gold standard for the diagnosis of IDPs while the possibility of under sample exists in the percutaneous biopsy. There have been some debates about how to treat asymptomatic IDPs without atypia diagnosed on core needle biopsy (CNB), especially when the upgrade rate to carcinoma is considered. This article concludes that further surgery is recommended for IDPs without atypia diagnosed on CNB who have high-risk factors, while appropriate imaging follow-up may be suitable for those without risk factors.
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Funding
This study was partially supported by Shanghai 2021 "Science and Technology Innovation Action Plan" Medical Innovation Research Special Project (21Y11923000); Sailing Program, Scientific and Innovative Action Plan of Shanghai (20YF1449800); Clinical Research Project in the Health Sector, Shanghai Health and Health Commission (20204Y0167); the Postgraduates’ Training Project of Shanghai University of Traditional Chinese Medicine (Y2021064) and PeiRan Plan projects of SHUTCM.
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TS and YY performed the literature survey and wrote the manuscript, YC corrected the manuscript, CH provided the theme and guided the manuscript writing. All authors read and approved the final manuscript.
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Tu, S., Yin, Y., Yuan, C. et al. Management of Intraductal Papilloma of the Breast Diagnosed on Core Needle Biopsy: Latest Controversies. Phenomics 3, 190–203 (2023). https://doi.org/10.1007/s43657-022-00085-8
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DOI: https://doi.org/10.1007/s43657-022-00085-8