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Light regulation in critical human pathogens of clinical relevance such as Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa

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Abstract

It is now clearly recognized that light modulates the physiology of many bacterial chemotrophs, either directly or indirectly. An interesting case are bacterial pathogens of clinical relevance. This work summarizes, discusses, and provides novel complementary information to what is currently known about light sensing and responses in critical human pathogens such as Acinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureus. These pathogens are associated with severe hospital and community infections difficult to treat due to resistance to multiple drugs. Moreover, light responses in Brucella abortus, an important animal and human pathogen, are also compiled. Evidence recovered so far indicates that light modulates aspects related to pathogenesis, persistence, and antibiotic susceptibility in these pathogens; such as motility, biofilm formation, iron uptake, tolerance to antibiotics, hemolysis and virulence. The pathogens elicit differential responses to light depending likely on their pathophysiology, ability to cause disease and characteristics of the host. The response to light is not restricted to discrete physiological traits but is global. In higher organisms, light provides spatial and temporal information. Then, it is crucial to understand what information light is providing in these bacterial pathogens. Our current hypothesis postulates that light serves as a signal that allows these pathogens to synchronize their behavior to the circadian rhythm of the host, to optimize infection. Advances on the molecular mechanism of light signal transduction and physiological responses to light, as well as in the relation between light and bacterial infection, would not only enlarge our understanding of bacterial pathogenesis but also could potentially provide alternative treatment options for infectious illnesses.

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All data generated or analysed during this study are included in this published article [and its supplementary information files].

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Acknowledgements

This work was supported by grants from the Agencia Nacional de Promoción Científica y Tecnológica (PICT 2019-01484) to MAM. MAM, JR and SK are career investigator of CONICET, while BPM, RG, NA and VP are fellows from the same institution. We thank Dr. Mario Feldman for the fruitful discussions regarding the role of light sensing in pathogen’s lifestyle.

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Authors and Affiliations

  1. Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI-CONICET), Universidad Nacional de Rosario (UNR), Rosario, Argentina

    Natalia Arana, Bárbara Perez Mora, Valentín Permingeat, Rocío Giordano, Malena Calderone, Gabriela Müller & María Alejandra Mussi

  2. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET), Rosario, Argentina

    Marisel Tuttobene

  3. Fundación Instituto Leloir, IIBBA-CONICET, Av. Patricias Argentinas 435, (C1405BWE) Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

    Sebastián Klinke & Jimena Rinaldi

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  1. Natalia Arana
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Correspondence to Gabriela Müller or María Alejandra Mussi.

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Arana, N., Perez Mora, B., Permingeat, V. et al. Light regulation in critical human pathogens of clinical relevance such as Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa. Photochem Photobiol Sci 22, 2019–2036 (2023). https://doi.org/10.1007/s43630-023-00437-x

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  • DOI: https://doi.org/10.1007/s43630-023-00437-x

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