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Association Between Potentially Functional Variants in chr5q14 and the Risk of Cervical Cancer in a Chinese Population

  • Gynecologic Oncology: Original Article
  • Published:
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Abstract

Cervical cancer is a complex polygenic disease, and the interaction between single-nucleotide polymorphisms (SNPs) may lead to differences in the incidence and susceptibility of cervical cancer. In this study, we explored whether three potentially functional SNPs—rs59661306, rs257847, and rs637442 with reference/alternative alleles A/G, C/T, and T/G, respectively—in chr5q14 were related to cervical cancer risk in a Chinese population. A total of 703 samples were collected, including 215 patients with cervical cancer and 488 normal controls. The SNP genotyping was determined by using polymerase chain reaction–restriction fragment length polymorphism. There was an association between the AG rs59661306 genotype or the GG rs59661306 genotype and cervical cancer risk, and the percentage of cancer patients with the A/G rs59661306 genotype plus the percentage of cancer patients with the G/G rs59661306 genotype (AG + GG) was significantly higher than the percentage of AG + GG healthy women in the control group. There was no association between either the rs257847 or the rs637442 and cervical cancer risk. Genotype analysis showed that the genotype CT of rs257847 in combination with the AG, GG, and AG + GG genotypes of rs59661306 were associated with a higher cervical cancer risk, and that the genotypes TG and TG + GG of rs637442 in combination with the AG and AG + GG genotypes of rs59661306 were also associated with a higher cervical cancer risk. These findings indicate that rs59661306, rs257847, and rs637442 may be susceptible loci for cervical cancer. Our study advances the understanding of SNPs that are responsible for cervical cancer susceptibility.

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All data generated or analyzed during this study are included in this published article. All authors confirm that all data and materials application support their published claims and comply with field standards.

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Acknowledgements

This study was funded by grants from the Key Research and Development Projects of Sichuan Science and Technology Department (2019YJ0044). We thank all participants for this study.

Funding

This work was supported by grants from the Key Research and Development Projects of Sichuan Science and Technology Department (2019YJ0044).

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, People’s Republic of China

    Ling Mei, Yueyue Chen, Dongmei Wei, Tao Cui, Yueting Zhang & Xiaoyu Niu

  2. Laboratory of Metabolomics and Gynecological Disease Research, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, People’s Republic of China

    Yuqing Liu, Xiaoli Zhang & Tao Wang

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  1. Yuqing Liu
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  2. Ling Mei
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  9. Xiaoyu Niu
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Contributions

All authors contributed to the study conception and design. Literature search, experimental studies, data analysis, statistical analysis, manuscript preparation, and manuscript editing were performed by Yuqing Liu and Ling Mei. Data acquisition, manuscript editing, and manuscript review were performed by Yueyue Chen, Xiaoli Zhang, Dongmei Wei, Tao Cui, Yueting Zhang, Tao Wang, and Xiaoyu Niu. Xiaoyu Niu takes responsibility for the integrity of the work as a whole from inception to published article. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Tao Wang or Xiaoyu Niu.

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Ethics Approval

This study was performed in line with the principles of the Declaration of Helsinki. The study was approved by the institutional ethics committee of West China Second Hospital of Sichuan University.

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Informed consent was obtained from all individual participants included in the study.

Consent for Publication

Consent for publication was obtained from all individual participants included in the study.

Competing Interests

The authors declare no competing interests.

Additional information

Yuqing Liu and Ling Mei have contributed equally to this work and share first authorship.

Tao Wang and Xiaoyu Niu have contributed equally to this work and share first authorship.

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Liu, Y., Mei, L., Chen, Y. et al. Association Between Potentially Functional Variants in chr5q14 and the Risk of Cervical Cancer in a Chinese Population. Reprod. Sci. 30, 301–308 (2023). https://doi.org/10.1007/s43032-022-01032-8

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  • DOI: https://doi.org/10.1007/s43032-022-01032-8

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