Abstract
This study investigated whether singleton pregnancies conceived after preimplantation genetic testing for chromosomal structural rearrangements (PGT-SR) are associated with a higher risk of adverse perinatal outcomes than singleton pregnancies conceived after intracytoplasmic sperm injection (ICSI). We collected data on singleton live births after PGT-SR (n = 107) and ICSI (n = 585) in our hospital from January 2017 to August 2020. Multivariable analyses were used to adjust for maternal age, body mass index, gravidity and parity, paternal age, ovulatory disorder, and recurrent spontaneous abortion. The unadjusted results showed a significantly higher risk of hypertensive disorders of pregnancy (HDP) (odds ratio (OR) = 2.47; 95% confidence interval (CI): 1.10–5.54; P = 0.029) associated with PGT-SR singleton pregnancies than with ICSI singleton pregnancies. However, after adjusting for potential confounders, there were no longer any significant differences in the risk of HDP (adjusted OR = 2.24; 95% CI: 0.92–5.48; P = 0.077) between PGT-SR and ICSI singleton pregnancies. There were no significant differences between PGT-SR and ICSI singleton pregnancies in terms of gestational diabetes, preterm premature rupture of membranes, placenta previa, cesarean delivery, gestational age (weeks), preterm delivery (< 37 weeks), very preterm delivery (≥ 28 weeks and < 32 weeks), birth weight (g), low birth weight (< 2500 g), very low birth weight (< 1500 g), birth height (cm), birth defects, and 1-min and 5-min Apgar scores. In conclusion, for single frozen-thawed blastocyst cycles, there were no significant differences in adverse perinatal outcomes between PGT-SR and ICSI singleton pregnancies. However, due to the limited sample size, these conclusions need to be confirmed by further studies.
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The data used during the current study are available from the corresponding author on reasonable request.
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Acknowledgements
Our thanks should go to all the nurses for follow-up and questionnaire registration.
Funding
This study was funded by grants received from Henan Science and Technology Development Plan (No. 202102310061) and State Key Laboratory of Reproductive Medicine, Nanjing Medical University (SKLRM-K201902 and SKLRM-K201903).
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W.Z., M.M., R.Y., and Y.G. contributed to the conception and design of this study. C.Y., S.Y., and J.L. contributed to the data acquisition. B.R. and R.Z. performed data analysis. The first draft of the manuscript was written by W.Z., B.R., and Y.L. Besides, X.L., S.R., H.W., and Y.G. contributed to the manuscript revision. All authors read and approved the final manuscript.
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This study was approved by the Ethics Committee of the Third Affiliated Hospital of Zhengzhou University (ethics approval number: 2021–029-01).
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Zheng, W., Ren, B., Mu, M. et al. Perinatal Outcomes of Singleton Live Births Following Preimplantation Genetic Testing for Chromosomal Structural Rearrangements in Single Frozen-Thawed Blastocyst Transfer Cycles: a Retrospective Cohort Study. Reprod. Sci. 29, 3039–3046 (2022). https://doi.org/10.1007/s43032-021-00732-x
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DOI: https://doi.org/10.1007/s43032-021-00732-x