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Meningiomas in Gynecology and Reproduction: an Updated Overview for Clinical Practice

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Abstract

There is various evidence to suggest a relationship between female hormones and meningiomas; as clinicians, we often come to face challenging situations involving female patients diagnosed with meningiomas during the post-pubertal phases of their life. We aimed to review the specific circumstances (pregnancy, postpartum, hormonal contraception and hormone replacement therapy, gender-affirming hormonal treatment) clinicians might come to face during their daily clinical practice, given the absence of available guidelines. We therefore conducted a narrative review on articles found in PubMed and Embase databases using appropriate keywords. Ninety-six relevant articles were included. The available evidence on managing meningiomas in post-pubertal women often implies personal strategies, highlighting the lack of a unified approach. The knowledge of the biological links between female hormones and meningiomas is fundamental to correctly counsel patients in various life phases. Prospective randomized studies are required to improve available guidelines on how to best manage meningiomas in female post-pubertal patients.

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Authors and Affiliations

  1. Obstetrics and Gynecology Department, I.R.C.C.S. San Raffaele Scientific Institute, Vita-Salute University, Via Olgettina 60, 20132, Milan, Italy

    Serena Girardelli, Giorgia Mangili, Luca Valsecchi, Emanuela Rabaiotti, Paolo Ivo Cavoretto & Massimo Candiani

  2. Neurosurgery and Radiosurgery Department, I.R.C.C.S. San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy

    Luigi Albano & Pietro Mortini

Authors
  1. Serena Girardelli
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  2. Luigi Albano
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  3. Giorgia Mangili
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  4. Luca Valsecchi
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  5. Emanuela Rabaiotti
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  6. Paolo Ivo Cavoretto
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  7. Pietro Mortini
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  8. Massimo Candiani
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Contributions

Serena Girardelli: conceptualization, methodology, investigation, resources, analysis and interpretation of data, and writing—original draft. Luigi Albano: conceptualization, methodology, investigation, resources, analysis and interpretation of data, and writing—original draft. Giorgia Mangili: conceptualization, supervision, and writing—reviewing and editing. Luca Valsecchi: visualization and writing—reviewing and editing. Emanuela Rabaiotti: visualization and writing—reviewing and editing. Paolo Cavoretto: visualization and writing—reviewing and editing. Pietro Mortini: writing—reviewing and editing. Massimo Candiani: writing—reviewing and editing.

Corresponding author

Correspondence to Serena Girardelli.

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Serena Girardelli and Luigi Albano are joint first authorship.

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Girardelli, S., Albano, L., Mangili, G. et al. Meningiomas in Gynecology and Reproduction: an Updated Overview for Clinical Practice. Reprod. Sci. 29, 2452–2464 (2022). https://doi.org/10.1007/s43032-021-00606-2

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  • DOI: https://doi.org/10.1007/s43032-021-00606-2

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