Abstract
This comprehensive overview explores sociocultural challenges in healthy eating and weight management, focusing on pharmacological interventions and psychotherapeutic options for care. The article evaluates the efficacy and safety of amphetamines, GLP-1 receptor agonists, and lipase blockers for weight loss. The emergence of GLP-1 agonists, such as liraglutide, semaglutide, and tirzepatide, is examined, emphasizing their potential benefits and drawbacks. The discussion delves into the complexities of weight loss pharmacology, considering societal influences, individual factors, and the importance of sustained behavioral changes. The vignette of Taylor's journey further underscores the need for a holistic approach, integrating psychological, behavioral, and environmental aspects for long-term weight management success.
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References
Barnes R. D., & Ivezaj V. (2015). A systematic review of motivational interviewing for weight loss among adults in primary care. Obesity Reviews, 16(4), 304-318.https://doi.org/10.1111/obr.12264
Befort, C. A., Stewart, E. E., Smith, B. K., Gibson, C. A., Sullivan, D. K., & Donnelly, J. E. (2008). Weight maintenance, behaviors, and barriers among previous participants of a university-based weight control program. International Journal of Obesity, 32(3), 519-526.https://doi.org/10.1038/sj.ijo.0803769
Bellisle, F. (2009). Deux questionnaires validés pour mesurer des aspects de la motivation à manger qui peuvent affecter le contrôle pondéral [Assessing various aspects of the motivation to eat that can affect food intake and body weight control]. L'Encephale, 35(2), 182–185. https://doi.org/10.1016/j.encep.2008.03.009
Bryant, E. J., Rehman, J., Pepper, L. B., & Walters, E. R. (2019). Obesity and eating disturbance: the role of TFEQ restraint and disinhibition. Current Obesity Reports, 8(4), 363-372. https://doi.org/10.1007/s13679-019-00365-x
Butryn, M. L., Thomas, J. G., Lowe, M. R. (2009). Reductions in internal disinhibition during weight loss predict better weight loss maintenance. Obesity, 17(5), 1101-1103. https://doi.org/10.1038/2Foby.2008.646
Caldwell, K., Baime, M., Wolever, R. (2012). Mindfulness based approaches to obesity and weight loss maintenance. Journal of Mental Health Counseling, 34(3), 269–282. https://doi.org/10.17744/mehc.34.3.t016616717774643
Cambi, M. P. C., Baretta, G. A. P., Magro, D. O., Boguszewski, C. L., Ribeiro, I. B., Jirapinyo, P., & de Moura, D. T. H. (2021). Multidisciplinary approach for weight regain-how to manage this challenging condition: An expert review. Obesity surgery, 31(3), 1290–1303. https://doi.org/10.1007/s11695-020-05164-1
Carrière, K., Khoury, B., Günak, M., M. & Knäuper, B. (2018). Mindfulness-based interventions for weight loss: a systematic review and meta-analysis. Obesity Reviews, 19(2), 164-177. https://doi.org/10.1111/obr.12623
ClinCalc. (2022). ClinCalc DrugStats Database: Free U.S. Outpatient Drug Usage Statistics (version 2022.08). Retrieved November 2023. https://clincalc.com/DrugStats/
Collins, R. (2005). Relapse prevention for eating disorders and obesity. In G. A. Marlatt & D. M. Donovan (Eds.), Relapse Prevention: Maintenance Strategies in the Treatment of Addictive Behaviors (2nd Edition, pp. 248-275). The Guilford Press.
Colquitt, J. L., Pickett, K., Loveman, E. & Frampton, G. K. (2014). Surgery for weight loss in adults. Cochrane Database of Systemic Reviews, 8, CD003641. https://doi.org/10.1002/14651858.cd003641.pub4
Coulter, A. A., Rebello, C. J., & Greenway, F. L. (2018). Centrally acting drugs for obesity: Past, present, and future. Drugs, 78, 1113–1132. https://doi.org/10.1007/s40265-018-0946-y
Forman, E. M., & Butryn, M. L. (2015). A new look at the science of weight control: how acceptance and commitment strategies can address the challenge of self-regulation. Appetite, 84, 171-180. https://doi.org/10.1016/j.appet.2014.10.004
Forman, E. M., Manasse S. M., Butryn, M. L., Crosby, R. D., Dallal, D. H., & Crochiere, R. J. (2019). Long-term follow-up of the mind your health project: acceptance-based versus standard behavioral treatment for obesity. Obesity, 27(4), 565-571. https://doi.org/10.1002/oby.22412
Gorin, A. A., Phelan, S., Wing, R. R., & Hill, J. O. (2004). Promoting long-term weight control: does dieting consistency matter? International Journal of Obesity and Related Metabolic Disorders, 28, 278-281. https://doi.org/10.1038/sj.ijo.0802550
Gloy, V. L., Briel, M., Bhatt, D. L., Kashyap, S. R., Schauer, P. R., Mingrone, G., Bucher, H. C. & Nordmann, A. J. (2013). Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomized controlled trials. BMJ, 2013;347:f5934. https://doi.org/10.1136/bmj.f5934
Hayes, S. C., Strosahl, K. D., & Wilson, K. G. (2012). Acceptance and commitment therapy: the process and practice of mindful change (2nd ed.). The Guilford Press.
Hays, N. P. & Roberts, S. B. (2008). Aspects of eating behaviors “disinhibition” and “restraint” are related to weight gain and BMI in women. Obesity, 16(1), 52-58. https://doi.org/10.1038/oby.2007.12
Hill, J. O., Wyatt, H., Phelan, S., & Wing, R. (2005). The National Weight Control Registry: is it useful in helping deal with our obesity epidemic? Journal of Nutrition Education and Behavior, 37(4), 206-210. https://doi.org/10.1016/s1499-4046(06)60248-0
Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., Wharton, S., Connery, L., Alves, B., Kiyosue, A., Zhang, S., Liu, B., Bunck, M. C., Stefanski, A., & SURMOUNT-1 Investigators (2022). Tirzepatide Once Weekly for the Treatment of Obesity. The New England Journal of Medicine, 387, 205–216. https://doi.org/10.1056/NEJMoa2206038
Jensen, A. B., Renström, F., Aczél, S., Folie, P., Biraima-Steinemann, M., Beuschlein, F., & Bilz, S. (2023). Efficacy of the Glucagon-Like Peptide-1 Receptor Agonists Liraglutide and Semaglutide for the Treatment of Weight Regain After Bariatric surgery: a Retrospective Observational Study. Obesity surgery, 33, 1017–1025. https://doi.org/10.1007/s11695-023-06484-8
Konttinen, H., Peltonen, M., Sjöström, L., Carlsson, L., & Karlsson, J. (2015). Psychological aspects of eating behavior as predictors of 10-y weight changes after surgical and conventional treatment of severe obesity: results from the Swedish Obese Subjects intervention study. American Journal of Clinical Nutrition, 101(1), 16–24. https://doi.org/10.3945/ajcn.114.095182
Levenge, E., Stapleton, P., & Sabot, D. (2020). Delineating the psychological and behavioral factors of successful weight loss maintenance. Heliyon, 6(1), e03100. https://doi.org/10.1016/j.heliyon.2019.e03100
Lillis, J., Thomas, J. G., Niemeier, H., & Wing, R. R. (2016a). Internal disinhibition predicts 5-year weight regain in the National Weight Control Registry (NWCR). Obesity Science and Practice, 2(1), 83-87. https://doi.org/10.1002/osp4.22
Lillis, J., Niemeier, H. M., Thomas, J. G., Unick, J., Ross, K. M., Leahey T. M., Kendra, K. E., Dorfman, L., & Wing, R. R. (2016b). A randomized trial of an acceptance-based behavioral intervention for weight loss in people with high internal disinhibition. Obesity, 24(12), 2509-2514. https://doi.org/10.1002/oby.21680
Magro, D. O., Geloneze, B., Delfini, R., Pareja, B. C., Callejas, F., Pareja, J. C. (2008). Long-term weight regain after gastric bypass: a 5-year prospective study. Obesity Surgery, 18, 648-651. https://doi.org/10.1007/s11695-007-9265-1
Mata, J., Silva, M. N., Vieira, P. N., Carraça, E. V., Andrade, A. M., Coutinho, S. R., Sardinha, L. B., & Teixeira, P. J. (2009). Motivational “spill-over” during weight control: Increased self-determination and exercise intrinsic motivation predict eating self-regulation. Health Psychology, 28(6), 709–716. https://doi.org/10.1037/a0016764
Moffitt, R., & Mohr, P. (2015). The efficacy of a self-managed acceptance and commitment therapy intervention DVD for physical activity initiation. British Journal of Health Psychology, 20(1), 115–129. https://doi.org/10.1111/bjhp.12098
Moore, C. F., Sabino, V., & Cottone, P. (2018). Trace Amine Associated Receptor 1(TAAR1) Modulation of Food Reward. Frontiers in Pharmacology, 9(129). https://doi.org/10.3389/fphar.2018.00129
Papatriantafyllou, E., Efthymiou, D., Zoumbaneas, E., Popescu, C., A. & Vassilopoulou, E. (2022). Sleep Deprivation: Effects on Weight Loss and Weight Loss Maintenance. Nutrients, 14(8), 1549. https://doi.org/10.3390/nu14081549
Phelan, S., Hill, J. O., Lang, W., Dibello, J. R., & Wing, R. R. (2003). Recovery from relapse among successful weight maintainers. The American journal of clinical nutrition, 78(6), 1079–1084. https://doi.org/10.1093/ajcn/78.6.1079
Raatz, S. K., Johnson, L. K., Caliquary, A., King, W. C., Kalarchian, M. A., Devlin, M. J., Marcus, M. D., & Mitchell, J. E. (2020). Reported nutrient intake over 7 years after Roux-en-Y gastric bypass in the longitudinal assessment of bariatric surgery-3 (LABS-3) psychosocial study. Surgery for Obesity and Related Diseases, 16(8), 1022-1029. https://doi.org/10.1016/j.soard.2020.04.007
Salmela, J., Konttinen, H., Lappalainen, R., Muotka, J., Antikainene, A., Lindström, J., Tuomilehto, J., Uusitupa., M., & Karhunen, L. (2023). Eating behavior dimensions and 9-year weight loss maintenance: a sub-study of the Finnish diabetes prevention study. International Journal of Obesity, 47, 564-573. https://doi.org/10.1038/s41366-023-01300-w
Shukla, A. P., He, D., Saunders, K. H., Andrew, C., & Aronne, L. J. (2018). Current concepts in management of weight regain following bariatric surgery. Expert review of endocrinology & metabolism, 13(2), 67–76. https://doi.org/10.1080/17446651.2018.1447922
Son, J. W., & Kim, S. (2020). Comprehensive review of current and upcoming anti-obesity drugs. Diabetes & Metabolism Journal, 44(6), 802-818. https://doi.org/10.4093/dmj.2020.0258
Stroebe, W., van Koningsbruggen, G. M., Papies, E. K., & Aarts, H. (2013). Why most dieters fail but some succeed: A goal conflict model of eating behavior. Psychological review, 120(1), 110–138. https://doi.org/10.1037/a0030849
Stunkard, A. & Messick, S. (1985). The three-factor eating questionnaire to measure dietary restraint, disinhibition, and hunger. Journal of Psychosomatic Research, 29(1), 71-83. https://doi.org/10.1016/0022-3999(85)90010-8
Sullivan, S., Cloninger, C. R., Przybeck, T. R., & Klein, S. (2007). Personality characteristics in obesity and relationship with successful weight loss. International Journal of Obesity, 31, 669–674. https://doi.org/10.1038/sj.ijo.0803464
Sutin, A. R., Ferrucci, L., Zonderman, A. B., & Terracciano, A. (2011). Personality and obesity across the adult lifespan. Journal of Personality & Social Psychology, 101(3), 579–592. https://doi.org/10.1037/a0024286
Teixeira, P. J., Silva, M. N., Coutinho, S. R., Palmeira, A. L., Mata, J., Vieira, P. N., Carraça, E. V., Santos, T. C., & Sardinha, L. B. (2010). Mediators of weight loss and weight loss maintenance in middle-aged women. Obesity, 18(4), 725-735. https://doi.org/10.1038/oby.2009.281
Teixeira, P. J., Going, S. B., Houtkooper, L. B., Cussler, E. C., Metcalfe, L. L., Blew, R. M., Sardinha, L. B., & Lohman, T. G. (2004). Pretreatment predictors of attrition and successful weight management in women. International Journal of Obesity and Related Metabolic Disorders, 28, 1124-1133. https://doi.org/10.1038/sj.ijo.0802727
Thomas, J. G., Bond, D. S., Phelan, S., Hill, J. O., & Wing, R. R. (2014). Weight-loss maintenance for 10 years in the National Weight Control Registry. American Journal of Preventative Medicine, 46(1), 17-23. https://doi.org/10.1016/j.amepre.2013.08.019
Voorwinde, V., Steenhuis, I. H. M., Janssen, I. M. C., Monpellier, V. M., van Stralen, M. M. (2020). Definitions of long-term weight regain and their associations with clinical outcomes. Obesity Surgery, 30, 527-536. https://doi.org/10.1007/s11695-019-04210-x
Weissman, N. J. (2001). Appetite suppressants and valvular heart disease. American Journal of the Medical Sciences, 321(4), 285-291. https://doi.org/10.1097/00000441-200104000-00008
Werner, J. (2019). Update on behavioral weight loss treatments to reduce obesity and lower cardiometabolic risks. Current Cardiovascular Risk Reports, 13, 25. https://doi.org/10.1007/s12170-019-0620-2
Westenhoefer, J. (1991). Dietary restraint and disinhibition: Is restraint a homogeneous construct? Appetite, 16(1), 45-55. https://doi.org/10.1016/0195-6663(91)90110-e
World Health Organization. (2021, June 9). Obesity and overweight [Fact Sheet]. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
Wing, R. R. & Hill, J. O. (2001). Successful weight loss maintenance. Annual Review of Nutrition, 21, 323-341. https://doi.org/10.1146/annurev.nutr.21.1.323
Wing, R. R., & Phelan, S. (2005). Long-term weight loss maintenance. American Journal of Clinical Nutrition, 82(1), 222S- 225S. https://doi.org/10.1093/ajcn/82.1.222S
Wyatt, H. R., Phelan, S., Wing, R. R., & Hill, J. O. (2005). Lessons from patients who have successfully maintained weight loss. Obesity Management, 1(2), 56 – 61. https://doi.org/10.1089/Obe.2005.1.56
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Marla M. Sanzone has no conflicts of interest to disclose. Morgan T. Sammons has no conflicts of interest to disclose.
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Sanzone, M., Sammons, M. Integrating Pharmacotherapy and Psychotherapy for Weight Loss. J Health Serv Psychol 49, 177–184 (2023). https://doi.org/10.1007/s42843-023-00095-8
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DOI: https://doi.org/10.1007/s42843-023-00095-8