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Correlation of clinical characteristics, by calculation of SCIO index, with the laboratory diagnosis of onychomycosis

  • Clinical Microbiology - Research Paper
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Abstract

Introduction

Onychomycosis is a chronic fungal infection with increasing incidence and the global prevalence is estimated to be 5.5%. The aim of our study was to perceive objectively severity of onychomycosis by calculating Scoring Clinical Index for Onychomycosis and to correlate this index with accurate laboratory diagnosis in our patients.

Materials and methods

The study population comprised of 417 patients with laboratory confirmed onychomycosis. For each patient, we recorded basic demographic information, site of infection, the most affected nail with onychomycosis, clinical presentation, and type of onychomycosis. The evaluation of the disease severity was based on Scoring Clinical Index for Onychomycosis which was calculated for every patient separately. Mycological identification was done by microscopy and fungal culture.

Results

The majority of patients had distal and lateral subungual onychomycosis (95.44%) that was localized on big toe (62.59%), with female to male ratio 1.24:1. Male patients had significantly more nails affected with onychomycosis compared with female patients (p = 0.011), while female had significantly more often onychomycosis on fingernails 2–5 (p < 0.05), and they reported significantly more often pain (p < 0.05) and esthetic problems (p < 0.05). Mean Scoring Clinical Index for Onychomycosis was 16.76. Dermatophytes were most frequently isolated (91.85%). In patients with onychomycosis caused by dermatophytes, Scoring Clinical Index for Onychomycosis had significantly higher values (p = 0.032).

Conclusion

Comprehensive understanding of disease characteristics will allow introduction of individualized treatment plan for each patient, based on proper fungal identification and standardized method of evaluating disease severity, which could help the patient achieve a complete cure.

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Funding

This work was supported by the Ministry of Education, Science, and Technological Development of Serbia (grant number: 175042).

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Authors and Affiliations

  1. Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

    Eleonora Dubljanin, Aleksandar Dzamic, Stefan Mijatovic & Ivana Colovic Calovski

  2. Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

    Isidora Vujcic & Sandra Sipetic Grujicic

  3. Faculty of Medicine, University of Belgrade, Belgrade, Serbia

    Teodora Crvenkov

Authors
  1. Eleonora Dubljanin
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  2. Aleksandar Dzamic
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Correspondence to Eleonora Dubljanin.

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Dubljanin, E., Dzamic, A., Vujcic, I. et al. Correlation of clinical characteristics, by calculation of SCIO index, with the laboratory diagnosis of onychomycosis. Braz J Microbiol 53, 221–229 (2022). https://doi.org/10.1007/s42770-021-00676-z

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