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Flexible Copper-Doped Silica Fibers Promote Infected Conjunctival Tissue Repair Through Antibacterial and Anti-inflammatory Effects

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Abstract

The conjunctiva is crucial in safeguarding the eye from harm or infection, thereby ensuring the preservation of the vision. The repair of infected conjunctival damage is necessary. The objective of this study is to develop copper-doped flexible silica nanofibers (SiO2@Cu NFs) with multifunctional antibacterial and anti-inflammatory characteristics. The continuous release of copper ions from electrospun membranes is shown to be effective to promote antibacterial and bioactive functions. Nanofiber membranes also exhibit biocompatibility and promote cell growth, angiogenesis, and inflammation modulation. In vivo evaluations further reveal the therapeutic efficacy of SiO2@Cu NFs to promote the structural and the functional recoveries of the conjunctiva. Taken together, SiO2@Cu NFs may hold significant promise for the fabrication of alternative ocular bandage to suppress bacterial infection and promote repair of ocular tissues and may potential be also used for related disciplines.

Graphical Abstract

Schematic diagram showing the fabrication of SiO2@Cu NFs for the regeneration of infected conjunctiva.

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Data Availability

Data will be made available on request.

Abbreviations

hAM:

Human amniotic membrane

ECM:

Extracellular matrix

PCL:

Poly(ε-caprolactone)

PLCL:

Poly(l-lactate-co-ε-caprolactone)

DDS:

Drug delivery systems

NMs:

Nanomaterials

NPs:

Nanoparticles

TEOS:

Tetraethyl orthosilicate

LPS:

Lipopolysaccharides

DPPH:

2,2-Diohenyl-1-picrylhydrazyl

RT:

Room temperature

SEM:

Scanning electron microscopy

EDS:

Energy-dispersive spectroscopy

FTIR:

Fourier-transform infrared spectroscopy

XRD:

X-ray diffraction

WCA:

Water contact angle

ICP:

Inductively coupled plasma atomic emission spectroscopy

NIH3T3:

NIH-3T3 fibroblasts

HUVEC:

Human umbilical vein endothelial cells

hSCF:

Human stromal fibroblasts

FBS:

Fetal bovine serum

UV:

Ultraviolet

CCK-8:

Cell counting kit-8

VEGF:

Vascular endothelial growth factor

ARVO:

Association of Vision and Ophthalmology Annual

H&E:

Hematoxylin and eosin staining

PAS:

Periodic acid-Schiff's

GO:

Gene Ontology

KEGG:

Kyoto Encyclopedia of Genes and Genomes

OD:

Optical density

DMEM:

Dulbecco’s modified Eagle medium

BCA:

Bicinchoninic acid

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Funding

This research was supported by Science and Technology Commission of Shanghai Municipality, China (Nos. 20S31900900, 20DZ2254900), Sino German Science Foundation Research Exchange Center, China (M-0263), and China Education Association for International Exchange (2022181). This project was also supported by Researchers Supporting Project Number (RSP2024R65), King Saud University, Riyadh, Saudi Arabia. Moreover, this project was supported by the State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University (KF2109), National Natural Science Foundation of China (No.82070919 and 82271041), the Program of Shanghai Academic/Technology Research Leader (22XD1401800); the Biomaterials and Regenerative Medicine Institute Cooperative Research Project, Shanghai Jiao Tong University School of Medicine (2022LHA06), Shanghai Key Clinical Specialty, and Shanghai Eye Disease Research Center (2022ZZ01003). This project was also supported by the Fundamental Research Funds for the Central Universities (CUSF-DH- T-2023064).

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Author notes

  1. Jie Cui and Yuchen Cai have contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, People’s Republic of China

    Jie Cui, Xiao Yu, Yihong Shen, Binbin Sun, Pengfei Cai, Zhengchao Yuan, Xingping Zhou & Xiumei Mo

  2. Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People’s Republic of China

    Yuchen Cai, Tianyi Zhou & Yao Fu

  3. Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, People’s Republic of China

    Yuchen Cai, Tianyi Zhou & Yao Fu

  4. Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, 3-25-14 Tono-machi, Kawasaki-ku, Kanagawa, 210-0821, Japan

    Muhammad Shafiq

  5. United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan

    Muhammad Shafiq

  6. Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, 11451, Riyadh, Saudi Arabia

    Mohamed EL-Newehy & Hany EL-Hamshary

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  1. Jie Cui
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  2. Yuchen Cai
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  10. Mohamed EL-Newehy
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  14. Xiumei Mo
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Correspondence to Xingping Zhou, Yao Fu or Xiumei Mo.

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Cui, J., Cai, Y., Yu, X. et al. Flexible Copper-Doped Silica Fibers Promote Infected Conjunctival Tissue Repair Through Antibacterial and Anti-inflammatory Effects. Adv. Fiber Mater. 6, 278–296 (2024). https://doi.org/10.1007/s42765-023-00358-5

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