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Atypical Central Neurocytoma Confined to the Third Ventricle: Case Report and Systematic Review of the Literature

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Abstract

Central neurocytomas are relatively rare well-differentiated neoplasms that arise from neuronal cells with the atypical variant having been noted to be more uncommon/aggressive. Herein, we present a case of an atypical neurocytoma confined to the third ventricle and in so doing review surgical management and outcomes associated with such tumors. We identify a number of cases of central neurocytomas within the third ventricle and clarify both clinical presentation and disease course. Central neurocytomas within the third ventricle are rare while atypical neurocytomas confined to the third ventricle are exceedingly rare. Review of the literature suggests gross total resection should be the preferred treatment modality for these tumors, atypical or not. When only subtotal resection can be achieved, postoperative radiation might be helpful to control tumor recurrence rates.

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Funding

This work was accomplished with the support from the University of Alabama at Birmingham Medical Scientist Training Program to Joshua Bernstock.

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Authors and Affiliations

  1. Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, 35233, USA

    Gustavo Chagoya, Joshua D. Bernstock & Galal Elsayed

  2. Medical Scientist Training Program, University of Alabama at Birmingham, Birmingham, AL, 35233, USA

    Joshua D. Bernstock

  3. Department of Neurosurgery, University Hospital Frankfurt, Goethe-University, Schleusenweg 2-16, 60528, Frankfurt, Germany

    Florian Gessler

  4. Departments of Neurosurgery and Neurobiology, Duke University Medical Center, Durham, NC, 27710, USA

    Ranjith Babu & Allan H. Friedman

  5. Department of Neurosurgery, Emory University Hospital, Atlanta VA Medical Center, Atlanta, GA, 30322, USA

    D. Cory Adamson

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  1. Gustavo Chagoya
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  2. Joshua D. Bernstock
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  3. Galal Elsayed
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  4. Florian Gessler
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  5. Ranjith Babu
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  7. D. Cory Adamson
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Contributions

Cory Adamson and Ranjith Babu conceived the case report. Allan Friedman performed the operation. Gustavo Chagoya, Joshua Bernstock, Galal Elsayed, and Ranjith Babu prepared the figures and wrote the manuscript. Gustavo Chagoya and Ranjith Babu collected and managed data. Florian Gessler provided additional expert opinion and contributed significant revisions. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Gustavo Chagoya.

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Conflict of Interest

Joshua Bernstock has positions/equity in CITC Ltd and Avidea Technologies. All other authors declare that they have no competing interests.

Ethical Approval

This study fell under exemption from the Duke University Hospital (DUHS) Institutional Review Board (IRB) in accordance to federal regulations (45CFR46.102(d) and 45CFR164.501). The review of medical records for publication of a single case report or a case series involving data from two or three patients is not considered by the DUHS IRB to be research involving human subjects, and therefore such a report of medical cases does not require IRB review and approval. The data presented in this study is de-identified in accordance to and does not violate regulations mandated by the Health Insurance Portability and Accountability Act of 1996 (HIPAA).

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Written informed consent was obtained from the patient for publication of this case report and any accompanying images at the time of surgery in accordance to institutional regulations.

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Chagoya, G., Bernstock, J.D., Elsayed, G. et al. Atypical Central Neurocytoma Confined to the Third Ventricle: Case Report and Systematic Review of the Literature. SN Compr. Clin. Med. 1, 972–980 (2019). https://doi.org/10.1007/s42399-019-00162-6

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