Avoid common mistakes on your manuscript.
This is our second issue of 2023 and it is heavy on research on various aspects of the metabolic syndrome. This is, of course, particularly appropriate as insulin resistance, prediabetic states, and frank diabetes are impacting an even larger part of the population worldwide than they were just a few years ago. It is estimated that up to half of the population of the USA will be obese by 2030 [1]. Obesity should be seen by all as a disease, chronic, and relapsing, regardless of the cause [2].
Several articles in this issue, including the role of the gastric fundus on glycemic control [3], the molecular mechanisms of diabetic nephropathy [4] and the effects of epicardial adipose tissue on cardiac function [5], the use of an insulin-mimetic compound in rats [6], and the study of insulin resistance-associated parameters in the US population [7] come in parallel with the increasing use of semaglutide and similar drugs for weight loss. On March 2, 2023, The Economist, a non-scientific journal that mainly deals with economic and political issues, dedicated its cover to this new class of medications, the title being “Eat, inject, repeat” [8]. It is a recognition of the impact of obesity globally on healthcare systems and society at large. In the USA, five medications (orlistat, phentermine plus topiramate, naltrexone plus bupropion, liraglutide, and semaglutide) have been approved for long-term use in individuals with a body mass index (BMI) of 30 or more with no weight-related comorbidities or 27 or more with weight-related comorbidities [9]. Interestingly, we read in this issue of the journal that obesity was recognized early in human societies, as seems to be demonstrated by the mother goddess found at the neolithic settlement in Çatalhöyük in what is now modern-day Turkey [10]. As previously stressed [11, 12], Hormones will continue to publish the highest quality research on all matters related to obesity, the metabolic syndrome and insulin resistance, along with their causes and treatments [13,14,15].
There are other excellent articles in this issue on reproductive endocrinology [16,17,18], including a historical assessment of whether Samson had high serum testosterone levels [19], as well as on the pituitary, the thyroid, and the adrenal glands [20,21,22,23,24,25,26,27,28], thereby continuing our wide coverage of all hormonal fields and always committed to publishing the best and the latest. Enjoy yet another remarkable collection of articles!
References
Ward ZJ, Bleich SN, Cradock AL et al (2019) Projected U.S. state-level prevalence of adult obesity and severe obesity. N Engl J Med 381(25):2440–2450
Heymsfield SB, Wadden TA (2017) Mechanisms, pathophysiology, and management of obesity. N Engl J Med 376(3):254–266
Kehagias D, Georgopoulos N, Habeos I, Lampropoulos C, Mulita F, Kehagias I (2023) The role of the gastric fundus in glycemic control. Hormones (Athens). https://doi.org/10.1007/s42000-023-00429-7
Zhao Y, Li D, Zhou P, Zhao Y, Kuang J (2023) microRNA-29b-3p attenuates diabetic nephropathy in mice by modifying EZH2. Hormones. https://doi.org/10.1007/s42000-022-00426-2
Christou GA, Andriopoulou CE, Liakopoulou A, Tsape E, Apostolakis E, Tselepis AD, Konstandi M, Frühbeck G, Kiortsis DN (2023) Unraveling the role of resistin, retinol-binding protein 4 and adiponectin produced by epicardial adipose tissue in cardiac structure and function: evidence of a paracrine effect. Hormones. https://doi.org/10.1007/s42000-023-00447-5
Gaique TG, Boechat SK, Neto JGO, Bento-Bernardes T, Medeiros RF, Pazos-Moura CC, Oliveira KJ (2023) Cinnamaldehyde supplementation acts as an insulin mimetic compound improving glucose metabolism during adolescence, but not during adulthood, in healthy male rats. Hormones. https://doi.org/10.1007/s42000-023-00442-w
Yan S, Wang D, Jia Y (2023) Comparison of insulin resistance-associated parameters in US adults: a cross-sectional study. Hormones. https://doi.org/10.1007/s42000-023-00448-4
The Economist; https://www.economist.com/the-world-this-week/2023/03/02/this-weeks-cover
Ghusn W, De la Rosa A, Sacoto D et al (2022) Weight loss outcomes associated with semaglutide treatment for patients with overweight or obesity. JAMA Netw Open 5(9):e2231982. https://doi.org/10.1001/jamanetworkopen.2022.31982
Elbe H (2023) Obesity and the mother goddess of neolithic Çatalhöyük. Hormones. https://doi.org/10.1007/s42000-023-00433-x
Stratakis CA (2023) COVID-19, diabetes mellitus type 2, endocrine genetics, and pituitary and adrenal diseases. Hormones 22(1):1–2. https://doi.org/10.1007/s42000-023-00436-8
Stratakis CA (2022) Note by Hormones’ new editor: metabolic syndrome plus obesity and COVID-19, the two concurrent pandemics and the field of endocrinology. Hormones 21(3):347–348. https://doi.org/10.1007/s42000-022-00390-x
Chantzaras A, Yfantopoulos J (2022) Association between medication adherence and health-related quality of life of patients with diabetes. Hormones 21(4):691–705
Figueiredo AR, Matos T, do Vale S (2023) Monitoring of continuous subcutaneous insulin infusion treatment in Portugal and its implications for diabetes management. Hormones 22(1):87–94. https://doi.org/10.1007/s42000-022-00412-8
Zhang T, Zhang D, Zhang Z, Tian J, An J, Zhang W, Ben Y (2023) Alpha-lipoic acid activates AMPK to protect against oxidative stress and apoptosis in rats with diabetic peripheral neuropathy. Hormones 22(1):95–105. https://doi.org/10.1007/s42000-022-00413-7
Whittaker J (2023) Dietary trends and the decline in male reproductive health. Hormones. https://doi.org/10.1007/s42000-023-00431-z
Karalexi MA, Kontogeorgi A, Papaioannou G, Neofytou S, Messaropoulos P, Moschovi M, Kalantaridou SN (2023) Fertility status in childhood cancer survivors of hematological malignancies: a systematic review. Hormones. https://doi.org/10.1007/s42000-023-00443-9
Zhang L, Wang H, Ma Q, Liu Y, Chen A, Lu J, Ren L (2023) Value of the triglyceride-glucose index and non-traditional blood lipid parameters in predicting metabolic syndrome in women with polycystic ovary syndrome. Hormones. https://doi.org/10.1007/s42000-023-00438-6
Mazokopakis EE (2023) Did Samson have high serum testosterone levels? Hormones. https://doi.org/10.1007/s42000-023-00441-x
Han AJ, Fleseriu M, Varlamov EV (2023) Symptoms at presentation in conservatively managed patients with non-functioning pituitary adenomas. Hormones. https://doi.org/10.1007/s42000-023-00444-8
Guerrero-Pérez F, Marengo AP, Vilarrasa N, Vidal N, Ruiz-Roig N, Sánchez-Fernández JJ, Torres-Díaz A, Sanmillán JL, Pérez-Maraver M, Villabona C (2023) Xanthogranuloma of the sellar region: a systematic review. Hormones. https://doi.org/10.1007/s42000-023-00432-y
Díez JJ, Iglesias P (2023) Prevalence of thyroid dysfunction and its relationship to income level and employment status: a nationwide population-based study in Spain. Hormones. https://doi.org/10.1007/s42000-023-00435-9
Katahira M, Tsunekawa T, Mizoguchi A, Yamaguchi M, Tsuru K, Takashima H, Terada R (2023) Clinical significance of thyroglobulin antibodies and thyroid peroxidase antibodies in Graves’ disease: a cross-sectional study. Hormones. https://doi.org/10.1007/s42000-023-00437-7
Zheng M, Xu L, Wei C, Guan W (2023) CircRTN1 stimulates HMGB1 to regulate the malignant progression of papillary thyroid cancer by sponging miR-101-3p. Hormones. https://doi.org/10.1007/s42000-023-00440-y
Yu Z, Gao J, Sun F (2023) The effect of unilateral adrenalectomy on patients with primary bilateral macronodular adrenal hyperplasia. Hormones 2023. https://doi.org/10.1007/s42000-023-00428-8
Monteiro A, Pavithran PV, Puthukulangara M, Bhavani N, Nampoothiri S, Yesodharan D, Kumaran R (2023) Cost-effective genotyping for classical congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) in resource-poor settings: multiplex ligation probe amplification (MLPA) with/without sequential next-generation sequencing (NGS). Hormones. https://doi.org/10.1007/s42000-023-00445-7
Bioletto F, Varaldo E, Prencipe N, Benso A, Berton AM (2023) Long-term efficacy of empagliflozin as an add-on treatment for chronic SIAD: a case report and literature review. Hormones. https://doi.org/10.1007/s42000-023-00430-0
Jiang Y, Yang J, Du K, Luo K, Yuan X, Hua F (2023) 1,25-Dihydroxyvitamin D3 alleviates hyperandrogen-induced ferroptosis in KGN cells. Hormones. https://doi.org/10.1007/s42000-023-00439-5
Author information
Authors and Affiliations
Corresponding author
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Stratakis, C.A. From obesity in ancient times to the very latest vital research data on metabolic syndrome and other significant updates. Hormones 22, 149–150 (2023). https://doi.org/10.1007/s42000-023-00452-8
Published:
Issue Date:
DOI: https://doi.org/10.1007/s42000-023-00452-8