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Assay of Biomarkers for Alzheimer’s Disease by Surface Plasmon Resonance

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Abstract

Alzheimer’s disease (AD) is one of the neurodegenerative diseases characterized by cognitive dysfunction and behavioral impairment. Early diagnosis of AD serves as a viable means to avoid the onset and progression of the disease. Due to the remarkably lower expression levels of AD biomarkers in cerebrospinal fluids and serum samples, sensitive and specific analytical methods are highly demanded. Surface plasmon resonance (SPR) is ultrasensitive to the refractive index or thickness change at the metal surface, which enables real-time and label-free assay of target biomolecules. In this review, we summarize the advances on assay of AD biomarkers including amyloid beta, tau protein, apoE proteins and apoE genes, and BACE1 by SPR, with emphasis on the analytical performances concerning anti-fouling and signal amplification strategies and real sample applications.

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Data availability

The data supporting the finding reported herein are available on reasonalbe request from the corresponding author.

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Acknowledgements

The authors thank the financial support of this work by the National Natural Science Foundation of China (22076221, 21876208), the Central South University Innovation-Driven Research Programme (2023CXQD022), and the Hunan Provincial Science and Technology Plan Project, China (2019TP1001).

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  1. Hunan Provincial Key Laboratory of Micro and Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China

    Xinyao Yi, Huihui Chen, Yuhan He & Jianxiu Wang

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Yi, X., Chen, H., He, Y. et al. Assay of Biomarkers for Alzheimer’s Disease by Surface Plasmon Resonance. J. Anal. Test. (2024). https://doi.org/10.1007/s41664-024-00299-x

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