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Porous Ruthenium Selenide Nanoparticle as a Peroxidase Mimic for Glucose Bioassay

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Abstract

Nanozyme is a promising field that offers the substitution for natural enzymes using various nanomaterials. Various nanomaterials with peroxidase-like activity were investigated. Among them, transition metal chalcogenides were explored as promising nanozymes due to their excellent enzyme-mimicking activities. However, ruthenium selenide has not been studied as a peroxidase mimic because of the difficulty for synthesis. Herein, we prepared ruthenium selenide nanomaterial with ordered mesoporous structure (P-RuSe2) employing KIT-6 silica as the template. The composition and structure of P-RuSe2 were fully characterized. Further, its peroxidase-like activity was investigated. P-RuSe2 possessed excellent peroxidase-mimicking activity, which catalyzed the oxidation of peroxidase substrates, including 3,3′,5,5′-tetramethylbenzidine, o-phenylenediamine, and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) in the presence of H2O2. Moreover, P-RuSe2 exhibited higher peroxidase-like activity when compared with several representative nanozymes as well as bulk RuSe2. To demonstrate its potential applications, the colorimetric detection systems for H2O2 and glucose were successfully constructed based on P-RuSe2 nanozyme.

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Acknowledgements

This work was supported by National Natural Science Foundation of China (21874067 and 21722503), 973 Program (2015CB659400), PAPD program, Shuangchuang Program of Jiangsu Province, Open Funds of the State Key Laboratory of Analytical Chemistry for Life Science (SKLACLS1704), Open Funds of the State Key Laboratory of Coordination Chemistry (SKLCC1819), Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education) (ACBM2019001), and Fundamental Research Funds for the Central Universities (021314380145).

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  1. Wen Cao, Junshu Lin and Faheem Muhammad have equal contributions.

Authors and Affiliations

  1. Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, 210093, Jiangsu, China

    Wen Cao, Junshu Lin, Faheem Muhammad, Quan Wang, Xiaoyu Wang, Zhangping Lou & Hui Wei

  2. Department of Biomaterials, College of Materials, Xiamen University, Xiamen, 361005, Fujian, China

    Junshu Lin & Hui Wei

  3. State Key Laboratory of Analytical Chemistry for Life Science and State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, Jiangsu, China

    Wen Cao, Junshu Lin, Faheem Muhammad, Quan Wang, Xiaoyu Wang, Zhangping Lou & Hui Wei

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  1. Wen Cao
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  2. Junshu Lin
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  4. Quan Wang
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Correspondence to Hui Wei.

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Cao, W., Lin, J., Muhammad, F. et al. Porous Ruthenium Selenide Nanoparticle as a Peroxidase Mimic for Glucose Bioassay. J. Anal. Test. 3, 253–259 (2019). https://doi.org/10.1007/s41664-019-00104-0

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