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Silver nanoparticles synthesized from Launaea sarmentosa extract: synthesis, characterization, and antimalarial activity

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Abstract

This paper describes a simple and effective green approach for synthesizing silver nanoparticles using Launaea sarmentosa aqueous plant extract. Phytoconstituents screening revealed the presence of tannins and phenolics, terpenoids, and alkaloids, all of which function as both bio-reductants and capping agents for silver nanoparticles formation. The influence of several experimental parameters in the synthesis of silver nanoparticles was optimized. Spectrophotometric analysis with a maximum absorbance peak of 430 nm was accomplished to confirm the successful formation of green silver nanoparticles. A range of characterization techniques was used to study the physicochemical properties of synthesized silver nanoparticles. The results demonstrated spherical and high-stability silver nanoparticles with an average diameter of approximately 30 nm. The silver nanoparticles greenly synthesized from Launaea sarmentosa extract exhibited good antiplasmodial potential against Plasmodium falciparum K1 strain with a 50% inhibitory concentration of 17.21 ± 1.18 µg mL−1 and a 100% growth inhibitor percentage of 312.5 µg mL−1. The proposed method provides a sustainable, low-cost, non-toxic, rapid, and reliable procedure to create silver nanoparticles, which could be a promising alternative treatment for malaria.

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All data supporting the findings of this study are available within the article. The data that support the findings of this study (TEM, SEM images, and EDS analysis) are available from the corresponding author upon request.

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References

  1. Mukherjee S et al (2014) Potential theranostics application of bio-synthesized silver nanoparticles (4-in-1 system). Theranostics 4(3):316–335

    Article  Google Scholar 

  2. Burdușel A-C et al (2018) Biomedical applications of silver nanoparticles: an up-to-date overview. Nanomaterials 8(9):681

    Article  Google Scholar 

  3. Yousef MS et al (2021) Antimicrobial activity of silver-carbon nanoparticles on the bacterial flora of bull semen. Theriogenology 161:219–227

    Article  Google Scholar 

  4. Li H et al (2015) Multifunctional aptamer-silver conjugates as theragnostic agents for specific cancer cell therapy and fluorescence-enhanced cell imaging. Anal Chem 87(7):3736–3745

    Article  Google Scholar 

  5. Mishra J et al (2021) Biofabricated smart-nanosilver: promising armamentarium for cancer and pathogenic diseases. Colloid Interface Sci Commun 44:100459

    Article  Google Scholar 

  6. Majeed M, Hakeem KR, Rehman RU (2022) Synergistic effect of plant extract coupled silver nanoparticles in various therapeutic applications-present insights and bottlenecks. Chemosphere 288(Pt 2):132527

    Article  Google Scholar 

  7. Xu L et al (2020) Silver nanoparticles: synthesis, medical applications and biosafety. Theranostics 10(20):8996–9031

    Article  Google Scholar 

  8. Avitabile E et al (2020) The potential antimalarial efficacy of hemocompatible silver nanoparticles from Artemisia species against P. falciparum parasite. PLoS ONE 15(9):e0238532

    Article  Google Scholar 

  9. Metwally DM et al (2021) Silver nanoparticles biosynthesized with Salvia officinalis leaf exert protective effect on hepatic tissue injury induced by Plasmodium chabaudi. Front Vet Sci 7:620665

    Article  Google Scholar 

  10. Borgheti-Cardoso LN et al (2020) Promising nanomaterials in the fight against malaria. J Mater Chem B 8(41):9428–9448

    Article  Google Scholar 

  11. Bahrulolum H et al (2021) Green synthesis of metal nanoparticles using microorganisms and their application in the agrifood sector. J Nanobiotechnol 19(1):86

    Article  Google Scholar 

  12. Roy A et al (2019) Green synthesis of silver nanoparticles: biomolecule-nanoparticle organizations targeting antimicrobial activity. RSC Adv 9(5):2673–2702

    Article  Google Scholar 

  13. Saratale RG et al (2021) Grape pomace extracted tannin for green synthesis of silver nanoparticles: assessment of their antidiabetic, antioxidant potential and antimicrobial activity. Polymers 13(24):4355

    Article  Google Scholar 

  14. Raja P et al (2014) Green synthesis of silver nanoparticles using tannins. Mater Sci-Poland 32(3):408–413

    Article  Google Scholar 

  15. Devi M et al (2020) Green synthesis of silver nanoparticles using methanolic fruit extract of Aegle marmelos and their antimicrobial potential against human bacterial pathogens. J Tradit Complement Med 10(2):158–165

    Article  Google Scholar 

  16. Vanlalveni C et al (2021) Green synthesis of silver nanoparticles using plant extracts and their antimicrobial activities: a review of recent literature. RSC Adv 11(5):2804–2837

    Article  Google Scholar 

  17. Das RK, Bhuyan D (2019) Microwave-mediated green synthesis of gold and silver nanoparticles from fruit peel aqueous extract of Solanum melongena L. and study of antimicrobial property of silver nanoparticles. Nanotechnol Environ Eng 4(1):5

    Article  Google Scholar 

  18. Adebayo AE et al (2019) Biosynthesis of silver, gold and silver–gold alloy nanoparticles using Persea americana fruit peel aqueous extract for their biomedical properties. Nanotechnol Environ Eng 4(1):13

    Article  Google Scholar 

  19. Akintelu SA, Bo Y, Folorunso AS (2020) A review on synthesis, optimization, mechanism, characterization, and antibacterial application of silver nanoparticles synthesized from plants. J Chem 2020:3189043

    Google Scholar 

  20. Gaddam SA et al (2021) Multifaceted phytogenic silver nanoparticles by an insectivorous plant Drosera spatulata Labill var. bakoensis and its potential therapeutic applications. Sci Rep 11(1):21969

    Article  Google Scholar 

  21. Buapoon S et al (2021) Naked-eye copper(II) sensing and antibacterial performance of silver nanoparticles synthesized using butterfly pea aqueous extract. Nanotechnol Environ Eng 6(2):38

    Article  Google Scholar 

  22. Khwannimit D et al (2019) Biologically green synthesis of silver nanoparticles from Citrullus lanatus extract with l-cysteine addition and investigation of colorimetric sensing of nickel(II) potential. Mater Today Proc 17:2028–2038

    Article  Google Scholar 

  23. Khwannimit D, Maungchang R, Rattanakit P (2020) Green synthesis of silver nanoparticles using Clitoria ternatea flower: an efficient catalyst for removal of methyl orange. Int J Environ Anal Chem 1–17. https://doi.org/10.1080/03067319.2020.1793974

  24. Wongyai K et al (2020) Exploration of the antimicrobial and catalytic properties of gold nanoparticles greenly synthesized by Cryptolepis buchanani Roem. and Schult extract. J Nanomater 2020:1320274

    Article  Google Scholar 

  25. Them LT et al (2019) Saponin, polyphenol, flavonoid content and α-glucosidase inhibitory activity, antioxidant potential of Launaea sarmentosa leaves grown in Ben Tre province, Vietnam. IOP Conf Ser Mater Sci Eng 542:012036

    Article  Google Scholar 

  26. Nguyen TQC et al (2020) Effects of Launaea sarmentosa extract on lipopolysaccharide-induced inflammation via suppression of NF-κB/MAPK signaling and Nrf2 activation. Nutrients 12(9):2586

    Article  Google Scholar 

  27. Pandya DD, Makwana H (2019) Launaea pinnatifida cass. A species of the controversial drug gojihva: comprehensive review. Int J Pharmacogn Phytochem Res 11:240–243

    Google Scholar 

  28. Khan Y et al (2017) Bio-synthesized silver nanoparticles using different plant extracts as anti-cancer agent. J Nanomed Biother Discov 7(2):154

    Google Scholar 

  29. Trager W, Jensen JB (1976) Human malaria parasites in continuous culture. Science 193(4254):673–675

    Article  Google Scholar 

  30. Lambros C, Vanderberg JP (1979) Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol 65(3):418–420

    Article  Google Scholar 

  31. Ramazani A et al (2010) In vitro and in vivo anti-malarial activity of Boerhavia elegans and Solanum surattense. Malar J 9(1):124

    Article  Google Scholar 

  32. Huang J et al (2011) Biogenic silver nanoparticles by Cacumen Platycladi extract: synthesis, formation mechanism, and antibacterial activity. Ind Eng Chem Res 50(15):9095–9106

    Article  Google Scholar 

  33. Rolim WR et al (2019) Green tea extract mediated biogenic synthesis of silver nanoparticles: characterization, cytotoxicity evaluation and antibacterial activity. Appl Surf Sci 463:66–74

    Article  Google Scholar 

  34. Heydari R, Rashidipour M (2015) Green synthesis of silver nanoparticles using extract of oak fruit hull (jaft): synthesis and in vitro cytotoxic effect on MCF-7 cells. Int J Breast Cancer 2015:846743

    Article  Google Scholar 

  35. Riaz M et al (2021) Exceptional antibacterial and cytotoxic potency of monodisperse greener AgNPs prepared under optimized pH and temperature. Sci Rep 11(1):2866

    Article  Google Scholar 

  36. Edison TJI, Sethuraman MG (2012) Instant green synthesis of silver nanoparticles using Terminalia chebula fruit extract and evaluation of their catalytic activity on reduction of methylene blue. Process Biochem 47(9):1351–1357

    Article  Google Scholar 

  37. Jain S, Mehata MS (2017) Medicinal plant leaf extract and pure flavonoid mediated green synthesis of silver nanoparticles and their enhanced antibacterial property. Sci Rep 7(1):15867

    Article  Google Scholar 

  38. Verma A, Mehata MS (2016) Controllable synthesis of silver nanoparticles using neem leaves and their antimicrobial activity. J Radiat Res Appl Sci 9(1):109–115

    Article  Google Scholar 

  39. Ashraf JM et al (2016) Green synthesis of silver nanoparticles and characterization of their inhibitory effects on AGEs formation using biophysical techniques. Sci Rep 6:20414

    Article  Google Scholar 

  40. Prakash P et al (2013) Green synthesis of silver nanoparticles from leaf extract of Mimusops elengi, Linn. for enhanced antibacterial activity against multi drug resistant clinical isolates. Colloids Surf B Biointerfaces 108:255–259

    Article  Google Scholar 

  41. Aboody MSA (2019) Silver/silver chloride (Ag/AgCl) nanoparticles synthesized from Azadirachta indica lalex and its antibiofilm activity against fluconazole resistant Candida tropicalis. Artif Cells Nanomed Biotechnol 47(1):2107–2113

    Article  Google Scholar 

  42. Patil MP et al (2018) Antibacterial potential of silver nanoparticles synthesized using Madhuca longifolia flower extract as a green resource. Microb Pathog 121:184–189

    Article  Google Scholar 

  43. Venkatesan J, Kim SK, Shim MS (2016) Antimicrobial, antioxidant, and anticancer activities of biosynthesized silver nanoparticles using marine algae Ecklonia cava. Nanomaterials 6(12):235

    Article  Google Scholar 

  44. Okaiyeto K, Hoppe H, Okoh AI (2021) Plant-based synthesis of silver nanoparticles using aqueous leaf extract of Salvia officinalis: characterization and its antiplasmodial activity. J Clust Sci 32(1):101–109

    Article  Google Scholar 

  45. Abboud Y et al (2013) Microwave-assisted approach for rapid and green phytosynthesis of silver nanoparticles using aqueous onion (Allium cepa) extract and their antibacterial activity. J Nanostruct Chem 3(1):84

    Article  Google Scholar 

  46. Liu L et al (2020) Tannic acid modified silver nanoparticles for enhancing anti-biofilms activities and modulating biofilms formation process. Biomater Sci 8:4852–4860

    Article  Google Scholar 

  47. Schreiner T et al (2021) Evaluation of saponin-rich extracts as natural alternative emulsifiers: a comparative study with pure Quillaja Bark saponin. Colloids Surf A Physicochem Eng Asp 623:126748

    Article  Google Scholar 

  48. Gangwar C et al (2021) Growth kinetic study of tannic acid mediated monodispersed silver nanoparticles synthesized by chemical reduction method and its characterization. ACS Omega 6(34):22344–22356

    Article  Google Scholar 

  49. Haldar K, Bhattacharjee S, Safeukui I (2018) Drug resistance in Plasmodium. Nat Rev Microbiol 16(3):156–170

    Article  Google Scholar 

  50. Rai M et al (2017) Recent advances in use of silver nanoparticles as antimalarial agents. Int J Pharm 526(1–2):254–270

    Article  Google Scholar 

  51. Mohammadi L et al (2021) Green nanoparticles to treat patients with Malaria disease: an overview. J Mol Struct 1229:129857

    Article  Google Scholar 

  52. Foko LPK et al (2019) A systematic review on anti-malarial drug discovery and antiplasmodial potential of green synthesis mediated metal nanoparticles: overview, challenges and future perspectives. Malar J 18:337

    Article  Google Scholar 

  53. Panneerselvam C, Sekar P, Murugan K (2011) Potential anti-plasmodial activity of synthesized silver nanoparticle using Andrographis paniculata nees (Acanthaceae). Arch Appl Sci Res 3(6):208–217

    Google Scholar 

  54. Ponarulselvam S et al (2012) Synthesis of silver nanoparticles using leaves of Catharanthus roseus Linn. G. Don and their antiplasmodial activities. Asian Pac J Trop Biomed 2(7):574–580

    Article  Google Scholar 

  55. Mishra A et al (2013) Evaluation of antiplasmodial activity of green synthesized silver nanoparticles. Colloids Surf B Biointerfaces 111:713–718

    Article  Google Scholar 

  56. Panneerselvam C, Murugan K, Amerasan D (2015) Biosynthesis of silver nanoparticles using plant extract and its anti-plasmodial property. Adv Mater Res 1086:11–30

    Article  Google Scholar 

  57. Murugan K et al (2015) Seaweed-synthesized silver nanoparticles: an eco-friendly tool in the fight against Plasmodium falciparum and its vector Anopheles stephensi?. Parasitol Res 114:4087–4097

    Article  Google Scholar 

  58. Panneerselvam C et al (2016) Fern-synthesized nanoparticles in the fight against malaria: LC/MS analysis of Pteridium aquilinum leaf extract and biosynthesis of silver nanoparticles with high mosquitocidal and antiplasmodial activity. Parasitol Res 115(3):997–1013

    Article  Google Scholar 

  59. Murugan K et al (2016) Eco-friendly drugs from the marine environment: spongeweed-synthesized silver nanoparticles are highly effective on Plasmodium falciparum and its vector Anopheles stephensi, with little non-target effects on predatory copepods. Environ Sci Pollut Res Int 23(16):16671–16685

    Article  Google Scholar 

  60. Murugan K et al (2016) In vivo and in vitro effectiveness of Azadirachta indica-synthesized silver nanocrystals against Plasmodium berghei and Plasmodium falciparum, and their potential against malaria mosquitoes. Res Vet Sci 106:14–22

    Article  Google Scholar 

  61. Dutta PP et al (2017) Antimalarial silver and gold nanoparticles: green synthesis, characterization and in vitro study. Biomed Pharmacother 91:567–580

    Article  Google Scholar 

  62. Sardana M et al (2018) Antiplasmodial activity of silver nanoparticles: a novel green synthesis approach. Asian Pac J Trop Biomed 8(5):268–272

    Article  Google Scholar 

  63. Ojemaye MO, Okoh SO, Okoh AI (2021) Silver nanoparticles (AgNPs) facilitated by plant parts of Crataegus ambigua Becker AK extracts and their antibacterial, antioxidant and antimalarial activities. Green Chemistry Lett Rev 14(1):51–61

    Article  Google Scholar 

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Acknowledgements

The authors kindly acknowledge the Plasmas and Electromagnetic Wave Science Centre of Excellence, and Functional Materials and Nanotechnology Centre of Excellence at Walailak University for providing necessary facilities. Benjamarachutit School is appreciated for their partial financial support. Special thanks are also express to Asst. Prof. Dr. Rasimate Maungchang for correction of the manuscript.

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Authors and Affiliations

  1. Benjamarachutit School, Nakhon Si Thammarat, 80000, Thailand

    Kotchaporn Chulasak

  2. School of Medicine, Walailak University, Nakhon Si Thammarat, 80160, Thailand

    Chuchard Punsawad

  3. School of Science, Walailak University, Nakhon Si Thammarat, 80160, Thailand

    Parawee Rattanakit

  4. Functional Materials and Nanotechnology Centre of Excellence, Walailak University, Nakhon Si Thammarat, 80160, Thailand

    Parawee Rattanakit

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  1. Kotchaporn Chulasak
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Correspondence to Parawee Rattanakit.

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Chulasak, K., Punsawad, C. & Rattanakit, P. Silver nanoparticles synthesized from Launaea sarmentosa extract: synthesis, characterization, and antimalarial activity. Nanotechnol. Environ. Eng. 7, 491–501 (2022). https://doi.org/10.1007/s41204-022-00239-z

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