Abstract
To investigate the synergistic effect of dexmedetomidine and cognitive behavioral therapy (CBT) on chronic insomnia. Forty-six chronic insomnia patients were selected and randomly assigned to the CBT group (CBT-I) or the CBT combined with dexmedetomidine (CBT-I + DEX) group. The sleep indexes and polysomnographic parameters were assessed before treatment, 4 weeks after treatment, and 8 weeks after treatment. The daily sleep conditions were recorded during the entire treatment course. Eight patients in the CBT-I group quit treatment, with a success rate of 65.2 %, and two patients in the CBT-I + DEX group quit treatment, with a success rate of 91.3 %, revealing a significant difference between the two groups (P < 0.05). At 4 and 8 weeks after treatment, the soma-arousal level was significantly decreased in the CBT-I + DEX group compared with the CBT-I group (P < 0.01), but no significant difference in the cognitive arousal. Polysomnographic monitoring results show that the sleep time at non-REM stage 3 (N3) and the total sleep time in the CBT-I + DEX group was longer than the CBT-I group after 4 weeks of treatment (P < 0.05). The number of awakenings, sleep latency, REM sleep latency and sleep efficiency were significantly improved in both groups at the end of treatment (P < 0.05), but the total sleep time was not obviously increased in both groups. Dexmedetomidine hydrochloride-induced sleep effectively reduced the patients’ arousal level, prolonged deep sleep, reduced the degree of daytime sleepiness, and improved the success rate of CBT.
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Abbreviations
- CBT:
-
Cognitive behavioral therapy
- DEX:
-
Dexmedetomidine
- DIS:
-
Dexmedetomidine induced sleep
- SCT:
-
Stimulus control therapy
- CR:
-
Cognitive restructuring
- RT:
-
Relaxation training
- SHE:
-
Sleep hygiene education
- SD:
-
Sleep diary
- ISI:
-
Insomnia Severity Index
- PSAS:
-
Pre-Sleep Arousal Scale
- HAS:
-
The Hyperarousal Scale
- PSQI:
-
The Pittsburgh Sleep Quality Index
- ESS:
-
The Epworth Sleepiness Scale
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The study was supported by the funding of new technology research about regulating center nerve hyperarousal state and correcting accumulated sleep debt (No. 12BJZ51).
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Li, X., Jiang, X., Liu, Y. et al. Efficacy of dexmedetomidine with cognitive behavioral therapy for treating chronic insomnia related to conditioned arousal: a randomized controlled trial. Sleep Biol. Rhythms 14, 75–85 (2016). https://doi.org/10.1007/s41105-015-0025-7
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DOI: https://doi.org/10.1007/s41105-015-0025-7