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From lighthouse to hothouse: hospital hygiene, antibiotics and the evolution of infectious disease, 1950–1990

  • Christoph GradmannEmail author
Original Paper
Part of the following topical collections:
  1. Microbes, Networks, Knowledge: Disease Ecology in the 20th Century

Abstract

Upon entering clinical medicine in the 1940s, antibiotic therapy seemed to complete a transformation of hospitals that originated in the late nineteenth century. Former death sinks had become harbingers of therapeutic progress. Yet this triumph was short-lived. The arrival of pathologies caused by resistant bacteria, and of nosocomial infections whose spread was helped by antibiotic therapies, seemed to be intimately related to modern anti-infective therapy. The place where such problems culminated were hospitals, which increasingly appeared as dangerous environments where attempts to combat infectious diseases had instead created hothouses of disease evolution. This paper will focus on one aspect of that history. It caused clinical medicine and hospital hygiene in particular to pay attention to a dimension of infectious disease it had previously paid little attention to thus far: The evolution of infectious disease—previously a matter of mostly theoretical interest—came to be useful in explaining many phenomena observed. This did not turn hospital hygienists into geneticists, though it did give them an awareness that the evolution of infectious disease in a broad sense was something that did matter to them. The paper advances its argument by looking at three phases: The growing awareness of the hospital as a dangerous environment in the 1950s, comprehensive attempts at improving antibiotic therapy and hospital hygiene that followed from the 1960s and lastly the framing of such challenges as risk factors from the 1970s. In conclusion, I will argue that hospital hygiene, being inspired in particular by epidemiology and risk factor analysis, discussed its own specific version of disease emergence and therefore contributed to the 1980s debates around such topics. Being loosely connected to more specialized studies, it consisted of a re-interpretation of infectious disease centred around the temporality of such phenomena as they were encountered in day-to-day dealings of clinical wards.

Keywords

Hospital infections Antibiotics resistance Disease evolution Epidemiology Risk factors Medical microbiology 

Notes

Acknowledgements

This paper is a much revised version of a presentation on the conference “Making Microbes Complex: Parasites, Epidemics and the Origins of Disease Ecology” held at QMUL July 7–8, 2016. I wish to thank the conference organizers Mark Honigsbaum (QMUL) and Pierre-Olivier Méthot (Université Laval, Québec) for inviting me. Both of them also gave valuable comments on the paper in its various stages of completion. Mathias Grote (HU Berlin) supplied a much appreciated critical reading of the manuscript.

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Authors and Affiliations

  1. 1.Section for Medical Anthropology and History, Institute of Health and SocietyUniversity of OsloOsloNorway

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