Pfaar O, Bachert C, Bufe A, Buhl R, Ebner C, Eng P, et al. Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases. Allergo J Int. 2014;23:282–319.
Article
PubMed
PubMed Central
Google Scholar
Ulrich JT, Myers KR. Monophosphoryl lipid A as an adjuvant. Past experiences and new directions. Pharm Biotechnol. 1995;6:495–524.
CAS
Article
PubMed
Google Scholar
Klimek L, Schmidt-Weber CB, Kramer MF, Skinner MA, Heath MD. Clinical use of adjuvants in allergen-immunotherapy. Expert Rev Clin Immunol. 2017;13:599–610.
CAS
Article
PubMed
Google Scholar
Klimek L, Willers J, Schendzielorz P, Kundig TM, Senti G. Immunotherapy of allergic rhinitis without allergens? : new options for immunomodulation by vaccination with virus-like particles and CpG motifs. HNO. 2013;61:826–33.
CAS
Article
PubMed
Google Scholar
Ring J, Gutermuth J. 100 years of hyposensitization: history of allergen-specific immunotherapy (ASIT). Arerugi. 2011;66:713–24.
CAS
Google Scholar
Bergmann KC, Ring J, editors. History of Allergy. Chemical Immunology and Allergy. Basel: Karger; 2014.
Google Scholar
Noon L. Prophylactic inoculation against hay fever. Lancet. 1911;177:1572–3.
Article
Google Scholar
Akdis M, Akdis CA. Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol. 2007;119:780–91.
CAS
Article
PubMed
Google Scholar
Bellinghausen I, Knop J, Saloga J. The role of interleukin 10 in the regulation of allergic immune responses. Int Arch Allergy Immunol. 2001;126:97–101.
CAS
Article
PubMed
Google Scholar
Bellinghausen I, Klostermann B, Böttcher I, Knop J, Saloga J. Importance of the inducible costimulator molecule for the induction of allergic immune responses and its decreased expression on T helper cells after venom immunotherapy. Immunology. 2004;112:80–6.
CAS
Article
PubMed
PubMed Central
Google Scholar
Francis JN, Till SJ, Durham SR. Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy. J Allergy Clin Immunol. 2003;111:1255–61.
CAS
Article
PubMed
Google Scholar
Jutel M, Akdis M, Budak F, Aebischer-Casaulta C, Wrzyszcz M, Blaser K, et al. IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol. 2003;33:1205–14.
CAS
Article
PubMed
Google Scholar
Wing K, Sakaguchi S. Regulatory T cells as potential immunotherapy in allergy. Curr Opin Allergy Clin Immunol. 2006;6:482–8.
Article
PubMed
Google Scholar
Bellinghausen I, König B, Böttcher I, Knop J, Saloga J. Regulatory activity of human CD4 CD25 T cells depends on allergen concentration, type of allergen and atopy status of the donor. Immunology. 2005;116:103–11.
CAS
Article
PubMed
PubMed Central
Google Scholar
Ling EM, Smith T, Nguyen XD, Pridgeon C, Dallman M, Arbery J, et al. Relation of CD4+CD25+ regulatory T‑cell suppression of allergen-driven T‑cell activation to atopic status and expression of allergic disease. Lancet. 2004;363:608–15.
CAS
Article
PubMed
Google Scholar
Passalacqua G, Durham SR, Global Allergy and Asthma European Network. Allergic rhinitis and its impact on asthma update: allergen immunotherapy. J Allergy Clin Immunol. 2007;119:881–91.
Article
PubMed
Google Scholar
Wachholz PA, Durham SR. Mechanisms of immunotherapy: IgG revisited. Curr Opin Allergy Clin Immunol. 2004;4:313–8.
CAS
Article
PubMed
Google Scholar
Novak N. Targeting dendritic cells in allergen immunotherapy. Immunol Allergy Clin North Am. 2006;26:307–19.
Article
PubMed
Google Scholar
Durham SR, Varney VA, Gaga M, Jacobson MR, Varga EM, Frew AJ, et al. Grass pollen immunotherapy decreases the number of mast cells in the skin. Clin Exp Allergy. 1999;29:1490–6.
CAS
Article
PubMed
Google Scholar
Pierkes M, Bellinghausen I, Hultsch T, Metz G, Knop J, Saloga J. Decreased release of histamine and sulfidoleukotrienes by human peripheral blood leukocytes after wasp venom immunotherapy is partially due to induction of IL-10 and IFN-gamma production of T cells. J Allergy Clin Immunol. 1999;103:326–32.
CAS
Article
PubMed
Google Scholar
Calderon MA, Alves B, Jacobson M, Hurwitz B, Sheikh A, Durham S. Allergen injection immunotherapy for seasonal allergic rhinitis. Cochrane Database Syst Rev. 2007; https://doi.org/10.1002/14651858.CD001936.pub2.
Article
PubMed
PubMed Central
Google Scholar
Radulovic S, Calderon MA, Wilson D, Durham S. Sublingual immunotherapy for allergic rhinitis. Cochrane Database Syst Rev. 2010; https://doi.org/10.1002/14651858.CD002893.
Article
PubMed
PubMed Central
Google Scholar
Walker SM, Durham SR, Till SJ, Roberts G, Corrigan CJ, Leech SC, et al. Immunotherapy for allergic rhinitis. Clin Exp Allergy. 2011;41:1177–200.
CAS
Article
PubMed
Google Scholar
Corrigan CJ, Kettner J, Doemer C, Cromwell O, Narkus A, Study Group.. Efficacy and safety of preseasonal-specific immunotherapy with an aluminium-adsorbed six-grass pollen allergoid. Arerugi. 2005;60:801–7.
CAS
Google Scholar
DuBuske LM, Frew AJ, Horak F, Keith PK, Corrigan CJ, Aberer W, et al. Ultrashort-specific immunotherapy successfully treats seasonal allergic rhinoconjunctivitis to grass pollen. Allergy Asthma Proc. 2011;32:239–47.
Article
CAS
PubMed
Google Scholar
Pfaar O, Urry Z, Robinson DS, Sager A, Richards D, Hawrylowicz CM, et al. A randomized placebo-controlled trial of rush preseasonal depigmented polymerized grass pollen immunotherapy. Allergy. 2012;67:272–9.
CAS
Article
PubMed
Google Scholar
Pfaar O, Robinson DS, Sager A, Emuzyte R. Immunotherapy with depigmented-polymerized mixed tree pollen extract: a clinical trial and responder analysis. Allergy. 2010;65:1614–21.
CAS
Article
PubMed
Google Scholar
Zielen S, Kardos P, Madonini E. Steroid-sparing effects with allergen-specific immunotherapy in children with asthma: a randomized controlled trial. J Allergy Clin Immunol. 2010;126:942–9.
CAS
Article
PubMed
Google Scholar
Tworek D, Bochenska-Marciniak M, Kuprys-Lipinska I, Kupczyk M, Kuna P. Perennial is more effective than preseasonal subcutaneous immunotherapy in the treatment of seasonal allergic rhinoconjunctivitis. Am J Rhinol Allergy. 2013;27:304–8.
Article
PubMed
PubMed Central
Google Scholar
Pfaar O, Lang S, Pieper-Fürst U, Astvatsatourov A, Gerich F, Klimek L, et al. Ultra-short-course booster is effective in recurrent grass pollen-induced allergic rhinoconjunctivitis. Allergy. 2018;73:187–95.
CAS
Article
PubMed
Google Scholar
Roberts G, Pfaar O, Akdis CA, Ansotegui IJ, Durham SR, Gerth van Wijk R, et al. EAACI Guidelines on Allergen Immunotherapy: Allergic rhinoconjunctivitis. Allergy. 2018;73:765–98.
CAS
Article
PubMed
Google Scholar
Canonica GW, Baena-Cagnani CE, Bousquet J, Bousquet PJ, Lockey RF, Malling HJ, et al. Recommendations for standardization of clinical trials with Allergen Specific Immunotherapy for respiratory allergy. A statement of a World Allergy Organization (WAO) taskforce. Arerugi. 2007;62:317–24.
CAS
Google Scholar
Pfaar O, Demoly P, Gerth van Wijk R, Bonini S, Bousquet J, Canonica GW, et al. European Academy of Allergy and Clinical Immunology. Recommendations for the standardization of clinical outcomes used in allergen immunotherapy trials for allergic rhinoconjunctivitis: an EAACI Position Paper. Allergy. 2014;69:854–67.
Article
Google Scholar
Englert L, May S, Kaul S, Vieths S. The therapy allergens ordinance (“Therapieallergene-Verordnung”). Background and effects. Bundesgesundheitsblatt. 2012;55:351–7.
CAS
Article
Google Scholar
Dolz I, Martinez-Cócera C, Bartolomé JM, Cimarra M. A double-blind, placebo-controlled study of immunotherapy with grass-pollen extract Alutard SQ during a 3-year period with initial rush immunotherapy. Allergy. 1996;51:489–500.
CAS
PubMed
Google Scholar
Frew AJ, Powell RJ, Corrigan CJ, Durham SR, UK Immunotherapy Study Group. Efficacy and safety of specific immunotherapy with SQ allergen extract in treatment-resistant seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol. 2006;117:319–25.
CAS
Article
PubMed
Google Scholar
Varney VA, Gaga M, Frew AJ, Aber VR, Kay AB, Durham SR. Usefulness of immunotherapy in patients with severe summer hay fever uncontrolled by antiallergic drugs. BMJ. 1991;302:265–9.
CAS
Article
PubMed
PubMed Central
Google Scholar
Roberts G, Hurley C, Turcanu V, Lack G. Grass pollen immunotherapy as an effective therapy for childhood seasonal allergic asthma. J Allergy Clin Immunol. 2006;117:263–8.
Article
PubMed
Google Scholar
Kepil Özdemir S, Sin BA, Güloğlu D, İkincioğulları A, Gençtürk Z, Mısırlıgil Z. Short-term preseasonal immunotherapy: is early clinical efficacy related to the basophil response? Int Arch Allergy Immunol. 2014;164:237–45.
Article
CAS
PubMed
Google Scholar
Zidarn M, Košnik M, Šilar M, Bajrović N, Korošec P. Sustained effect of grass pollen subcutaneous immunotherapy on suppression of allergen-specific basophil response; a real-life, nonrandomized controlled study. Allergy. 2015;70:547–55.
CAS
Article
PubMed
Google Scholar
Klimek L, Uhlig J, Mösges R, Rettig K, Pfaar O. A high polymerized grass pollen extract is efficacious and safe in a randomized double-blind, placebo-controlled study using a novel up-dosing cluster-protocol. Allergy. 2014;69:1629–38.
CAS
Article
PubMed
Google Scholar
Alvarez-Cuesta E, Aragoneses-Gilsanz E, Martín-Garcia C, Berges-Gimeno P, Gonzalez-Mancebo E, Cuesta-Herranz J. Immunotherapy with depigmented glutaraldehyde-polymerized extracts: changes in quality of life. Clin Exp Allergy. 2005;35:572–8.
CAS
Article
PubMed
Google Scholar
Drachenberg KJ, Wheeler AW, Stuebner P, Horak F. A well-tolerated grass pollen-specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseasonal injections. Allergy. 2001;56:498–505.
CAS
Article
PubMed
Google Scholar
Bozek A, Kolodziejczyk K, Krajewska-Wojtys A, Jarzab J. Pre-seasonal, subcutaneous immunotherapy: a double-blinded, placebo-controlled study in elderly patients with an allergy to grass. Ann Allergy Asthma Immunol. 2016;116:156–61.
Article
PubMed
Google Scholar
Arvidsson MB, Löwhagen O, Rak S. Effect of 2‑year placebo-controlled immunotherapy on airway symptoms and medication in patients with birch pollen allergy. J Allergy Clin Immunol. 2002;109:777–83.
CAS
Article
PubMed
Google Scholar
Bødtger U, Poulsen LK, Jacobi HH, Malling HJ. The safety and efficacy of subcutaneous birch pollen immunotherapy—a one-year, randomised, double-blind, placebo-controlled study. Allergy. 2002;57:297–305.
Article
PubMed
Google Scholar
Balda BR, Wolf H, Baumgarten C, Klimek L, Rasp G, Kunkel G, et al. Tree-pollen allergy is efficiently treated by short-term immunotherapy (STI) with seven preseasonal injections of molecular standardized allergens. Allergy. 1998;53:740–8.
CAS
Article
PubMed
Google Scholar
Höiby AS, Strand V, Robinson DS, Sager A, Rak S. Efficacy, safety, and immunological effects of a 2-year immunotherapy with Depigoid birch pollen extract: a randomized, double-blind, placebo-controlled study. Clin Exp Allergy. 2010;40:1062–70.
Article
CAS
PubMed
Google Scholar
Drachenberg KJ, Heinzkill M, Urban E. Kurzzeit-Immuntherapie mit Baumpollen-Allergoiden und dem Adjuvans Monophosphoryl Lipid A—Ergebnisse einer randomisierten, doppelblinden, plazebokontrollierten Multicenterstudie. Allergologie. 2002;25:466–74.
Article
Google Scholar
Ceuppens JL, Bullens D, Kleinjans H, van der Werf J, PURETHAL Birch Efficacy Study Group. Immunotherapy with a modified birch pollen extract in allergic rhinoconjunctivitis: clinical and immunological effects. Clin Exp Allergy. 2009;39:1903–9.
CAS
Article
PubMed
Google Scholar
Klimek L, Gröger M, Becker S. Milbenallergie im HNO-Bereich: Bedeutung, Diagnostik und Therapieoptionen. Laryngorhinootologie. 2018;97:56–69.
Article
PubMed
Google Scholar
Fernández-Caldas E. Towards a more complete standardization of mite allergen extracts. Int Arch Allergy Immunol. 2013;160:1–3.
Article
PubMed
Google Scholar
Vidal-Quist JC, Ortego F, Castañera P, Hernández-Crespo P. Quality control of house dust mite extracts by broad-spectrum profiling of allergen-related enzymatic activities. Allergy. 2017;72:425–34.
CAS
Article
PubMed
Google Scholar
Carnés J, Iraola V, Cho SH, Esch RE. Mite allergen extracts and clinical practice. Ann Allergy Asthma Immunol. 2017;118:249–56.
Article
CAS
PubMed
Google Scholar
Casset A, Mari A, Purohit A, Resch Y, Weghofer M, Ferrara R, et al. Varying allergen composition and content affects the in vivo allergenic activity of commercial Dermatophagoides pteronyssinus extracts. Int Arch Allergy Immunol. 2012;159:253–62.
CAS
Article
PubMed
Google Scholar
Haugaard L, Dahl R, Jacobsen L. A controlled dose-response study of immunotherapy with standardized, partially purified extract of house dust mite: clinical efficacy and side effects. J Allergy Clin Immunol. 1993;91:709–22.
CAS
Article
PubMed
Google Scholar
Pfaar O, Nell MJ, Boot JD, Versteeg SA, van Ree R, Roger A, et al. A randomized, 5‑arm dose finding study with a mite allergoid SCIT in allergic rhinoconjunctivitis patients. Allergy. 2016;71:967–76.
CAS
Article
PubMed
Google Scholar
Moreno V, Alvariño M, Rodríguez F, Roger A, Peña-Arellano MI, Lleonart R, et al. Randomized dose-response study of subcutaneous immunotherapy with a Dermatophagoides pteronyssinus extract in patients with respiratory allergy. Immunotherapy. 2016;8:265–77.
CAS
Article
PubMed
Google Scholar
Bożek A, Kołodziejczyk K, Kozłowska R, Canonica GW. Evidence of the efficacy and safety of house dust mite subcutaneous immunotherapy in elderly allergic rhinitis patients: a randomized, double-blind placebo-controlled trial. Clin Transl Allergy. 2017;7:43.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lozano J, Cruz MJ, Piquer M, Giner MT, Plaza AM. Assessing the efficacy of immunotherapy with a glutaraldehyde-modified house dust mite extract in children by monitoring changes in clinical parameters and inflammatory markers in exhaled breath. Int Arch Allergy Immunol. 2014;165:140–7.
CAS
Article
PubMed
Google Scholar
Yukselen A, Kendirli SG, Yilmaz M, Altintas DU, Karakoc GB. Effect of one-year subcutaneous and sublingual immunotherapy on clinical and laboratory parameters in children with rhinitis and asthma: a randomized, placebo-controlled, double-blind, double-dummy study. Int Arch Allergy Immunol. 2012;157:288–98.
CAS
Article
PubMed
Google Scholar
Ameal A, Vega-Chicote JM, Fernndez S, Miranda A, Carmona MJ, Rondn MC et al. Double-blind and placebo-controlled study to assess efficacy and safety of a modified allergen extract of Dermatophagoides pteronyssinus in allergic asthma. Allergy 2005:60:1178–83
CAS
Article
PubMed
Google Scholar
Garcia-Robaina J-C, Sánchez I, de la Torre F, Fernández-Caldas E, Casanovas M. Successful management of mite-allergic asthma with modified extracts of Dermatophagoides pteronyssinus and Dermatophagoides farinae in a double-blind, placebo-controlled study. J Allergy Clin Immunol 2006;118:1026–32
Article
PubMed
Google Scholar
Metzger WJ, Dorminey HC, Richerson HB, Weiler JM, Donnelly A, Moran D. Clinical and immunologic evaluation of glutaraldehyde-modified tyrosine-adsorbed short ragweed extract: a double-blind, placebo-controlled trial. J Allergy Clin Immunol. 1981;68:442–8.
CAS
Article
PubMed
Google Scholar
Blumberga G, Groes L, Dahl R. SQ-standardized house dust mite immunotherapy as an immunomodulatory treatment in patients with asthma. Allergy. 2011;66:178–85.
CAS
Article
PubMed
Google Scholar
Gallego MT, Iraola V, Himly M, Robinson DS, Badiola C, García-Robaina JC, et al. Depigmented and polymerised house dust mite allergoid: allergen content, induction of IgG4 and clinical response. Int Arch Allergy Immunol. 2010;153:61–9.
CAS
Article
PubMed
Google Scholar
Riechelmann H, Schmutzhard J, van der Werf JF, Distler A, Kleinjans HA. Efficacy and safety of a glutaraldehyde-modified house dust mite extract in allergic rhinitis. Am J Rhinol Allergy. 2010;24:e104–9.
Article
PubMed
Google Scholar
Wang H, Lin X, Hao C, Zhang C, Sun B, Zheng J, et al. A double-blind, placebo-controlled study of house dust mite immunotherapy in Chinese asthmatic patients. Allergy. 2006;61:191–7.
CAS
Article
PubMed
Google Scholar
Dokic D, Schnitker J, Narkus A, Cromwell O, Frank E. Clinical effects of specific immunotherapy: a two-year double-blind, placebo-controlled study with a one year follow-up. Prilozi. 2005;26:113–29.
CAS
PubMed
Google Scholar
Varney VA, Tabbah K, Mavroleon G, Frew AJ. Usefulness of specific immunotherapy in patients with severe perennial allergic rhinitis induced by house dust mite: a double-blind, randomized, placebo-controlled trial. Clin Exp Allergy. 2003;33:1076–82.
CAS
Article
PubMed
Google Scholar
Olsen OT, Larsen KR, Jacobsan L, Svendsen UG. A 1‑year, placebo-controlled, double-blind house-dust-mite immunotherapy study in asthmatic adults. Allergy. 1997;52:853–9.
CAS
Article
PubMed
Google Scholar
Ewan PW, Alexander MM, Snape C, Ind PW, Agrell B, Dreborg S. Effective hyposensitization in allergic rhinitis using a potent partially purified extract of house dust mite. Clin Allergy. 1988;18:501–8.
CAS
Article
PubMed
Google Scholar
Armentia-Medina A, Tapias JA, Martin JF, Ventas P, Fernández A. Immunotherapy with the storage mite lepidoglyphus destructor. Allergol Immunopathol. 1995;23:211–23.
CAS
Google Scholar
Buters J, Alberternst B, Nawrath S, Wimmer M, Traidl-Hoffmann C, Starfinger U, et al. Ambrosia artemisiifolia (ragweed) in Germany—current presence, allergological relevance and containment procedures. Allergo J Int. 2015;24:108–20.
Article
PubMed
PubMed Central
Google Scholar
Lake IR, Jones NR, Agnew M, Goodess CM, Giorgi F, Hamaoui-Laguel L, et al. Climate Change and Future Pollen Allergy in Europe. Environ Health Perspect. 2017;125:385–91.
Article
PubMed
Google Scholar
Patel P, Holdich T, Fischer von Weikersthal-Drachenberg KJ, Huber B. Efficacy of a short course of specific immunotherapy in patients with allergic rhinoconjunctivitis to ragweed pollen. J Allergy Clin Immunol. 2014;133:121–129.e1-2.
Article
PubMed
Google Scholar
Norman PS, Lichtenstein LM, Kagey-Sobotka A, Marsh DG. Controlled evaluation of allergoid in the immunotherapy of ragweed hay fever. J Allergy Clin Immunol. 1982;70:248–60.
CAS
Article
PubMed
Google Scholar
Grammer LC, Shaughnessy MA, Bernhard MI, Finkle SM, Pyle HR, Silvestri L, et al. The safety and activity of polymerized ragweed: a double-blind, placebo-controlled trial in 81 patients with ragweed rhinitis. J Allergy Clin Immunol. 1987;80:177–83.
CAS
Article
PubMed
Google Scholar
Iliopoulos O, Proud D, Adkinson NF Jr, Creticos PS, Norman PS, Kagey-Sobotka A, et al. Effects of immunotherapy on the early, late, and rechallenge nasal reaction to provocation with allergen: changes in inflammatory mediators and cells. J Allergy Clin Immunol. 1991;87:855–66.
CAS
Article
PubMed
Google Scholar
Brunet C, Bédard PM, Lavoie A, Jobin M, Hébert J. Allergic rhinitis to ragweed pollen. I. Reassessment of the effects of immunotherapy on cellular and humoral responses. J Allergy Clin Immunol. 1992;89:76–86.
CAS
Article
PubMed
Google Scholar
Mirone C, Albert F, Tosi A, Mocchetti F, Mosca S, Giorgino M, et al. Efficacy and safety of subcutaneous immunotherapy with a biologically standardized extract of Ambrosia artemisiifolia pollen: a double-blind, placebo-controlled study. Clin Exp Allergy. 2004;34:1408–14.
CAS
Article
PubMed
Google Scholar
Creticos PS, Reed CE, Norman PS, Khoury J, Adkinson NF Jr, Buncher CR, et al. Ragweed immunotherapy in adult asthma. N Engl J Med. 1996;334:501–6.
CAS
Article
PubMed
Google Scholar
Guerra F, Daza JC, Almeda E. Immunotherapy with a depigmented, polymerized vaccine of Olea europaea pollen allergens. Significantly reduces specific bronchial and skin test reactivity in sensitized patients after one year of treatment. J Investig Allergol Clin Immunol. 2003;13:108–17.
CAS
PubMed
Google Scholar
Gokmen NM, Ersoy R, Gulbahar O, Ardeniz O, Sin A, Unsel M, et al. Desensitization effect of preseasonal seven-injection allergoid immunotherapy with olive pollen on basophil activation: the efficacy of olive pollen-specific preseasonal allergoid immunotherapy on basophils. Int Arch Allergy Immunol. 2012;159:75–82.
CAS
Article
PubMed
Google Scholar
Ferrer M, Burches E, Peláez A, Muñoz A, Hernández D, Basomba A, et al. Double-blind, placebo-controlled study of immunotherapy with Parietaria judaica: clinical efficacy and tolerance. J Investig Allergol Clin Immunol. 2005;15:283–92.
CAS
PubMed
Google Scholar
Crimi N, Gotti LF, Mangano G, Paolino G, Mastruzzo C, Vancheri C, et al. A randomized, controlled study of specific immunotherapy in monosensitized subjects with seasonal rhinitis: effect on bronchial hyperresponsiveness, sputum inflammatory markers and development of asthma symptoms. Ann Ital Med Int. 2004;19:98–108.
PubMed
Google Scholar
Ortolani C, Pastorello EA, Incorvaia C, Ispano M, Farioli L, Zara C, et al. A double-blind, placebo-controlled study of immunotherapy with an alginate-conjugated extract of Parietaria judaica in patients with Parietaria hay fever. Allergy. 1994;49:13–21.
CAS
Article
PubMed
Google Scholar
Ariano R, Kroon AM, Augeri G, Canonica GW, Passalacqua G. Long-term treatment with allergoid immunotherapy with Parietaria. Clinical and immunologic effects in a randomized, controlled trial. Allergy. 1999;54:313–9.
CAS
Article
PubMed
Google Scholar
Tari MG, Mancino M, Ghezzi E, Frank E, Cromwell O. Immunotherapy with an alum-adsorbed Parietaria-pollen allergoid: a 2-year, double-blind, placebo-controlled study. Allergy. 1997;52:65–74.
CAS
Article
PubMed
Google Scholar
Charpin D, Gouitaa M, Dron-Gonzalvez M, Fardeau MF, Massabie-Bouchat YP, Hugues B, et al. Immunotherapy with an aluminum hydroxide-adsorbed Juniperus ashei foreign pollen extract in seasonal indigenous cypress pollen rhinoconjunctivitis. A double-blind, placebo-controlled study. Int Arch Allergy Immunol. 2007;143:83–91.
CAS
Article
PubMed
Google Scholar
Varney VA, Edwards J, Tabbah K, Brewster H, Mavroleon G, Frew AJ. Clinical efficacy of specific immunotherapy to cat dander: a double-blind placebo-controlled trial. Clin Exp Allergy. 1997;27:860–7.
CAS
Article
PubMed
Google Scholar
Ohman JL Jr, Findlay SR, Leitermann KM. Immunotherapy in cat-induced asthma. Double-blind trial with evaluation of in vivo and in vitro responses. J Allergy Clin Immunol. 1984;74:230–9.
Article
PubMed
Google Scholar
Taylor WW, Ohman JL Jr, Lowell FC. Immunotherapy in cat-induced asthma. Double-blind trial with evaluation of bronchial responses to cat allergen and histamine. J Allergy Clin Immunol. 1978;61:283–7.
CAS
Article
PubMed
Google Scholar
Patel D, Couroux P, Hickey P, Salapatek AM, Laidler P, Larché M, et al. Fel d 1‑derived peptide antigen desensitization shows a persistent treatment effect 1 year after the start of dosing: a randomized, placebo-controlled study. J Allergy Clin Immunol. 2013;131:103–109.e1–7.
CAS
Article
PubMed
Google Scholar
Gerth van Wijk R. Positive and negative AIT trials: What makes the difference? Allergo J Int. 2018;27:167–72.
Article
PubMed
PubMed Central
Google Scholar
Frew AJ, Pfaar O. Placebo effects in allergen immunotherapy: an experts’ opinion. Allergo J Int. 2018;27:162–6.
Article
PubMed
PubMed Central
Google Scholar
Fukutomi Y, Taniguchi M. Sensitization to fungal allergens: resolved and unresolved issues. Allergol Int. 2015;64:321–31.
CAS
Article
PubMed
Google Scholar
Coop CA. Immunotherapy for mold allergy. Clin Rev Allergy Immunol. 2014;47:289–98.
CAS
Article
PubMed
Google Scholar
Kuna P, Kaczmarek J, Kupczyk M. Efficacy and safety of immunotherapy for allergies to Alternaria alternata in children. J Allergy Clin Immunol. 2011;127:502–508.e1–6.
CAS
Article
PubMed
Google Scholar
Ostergaard PA, Kaad PH, Kristensen T. A prospective study on the safety of immunotherapy in children with severe asthma. Allergy. 1986;41:588–93.
CAS
Article
PubMed
Google Scholar
Kaad PH, Ostergaard PA. The hazard of mould hyposensitization in children with asthma. Clin Allergy. 1982;12:317–20.
CAS
Article
PubMed
Google Scholar
Tabar AI, Lizaso MT, García BE, Echechipía S, Olaguibel JM, Rodríguez A. Tolerance of immunotherapy with a standardized extract of Alternaria tenuis in patients with rhinitis and bronchial asthma. J Investig Allergol Clin Immunol. 2000;10:327–33.
CAS
PubMed
Google Scholar
Bozek A, Pyrkosz K. Immunotherapy of mold allergy: a review. Hum Vaccin Immunother. 2017;13:2397–401.
CAS
Article
PubMed
PubMed Central
Google Scholar
Tabar AI, Lizaso MT, García BE, Gómez B, Echechipía S, Aldunate MT, et al. Double-blind, placebo-controlled study of Alternaria alternata immunotherapy: clinical efficacy and safety. Pediatr Allergy Immunol. 2008;19:67–75.
PubMed
Google Scholar
Kiliç M, Altintaş DU, Yilmaz M, Bingöl-Karakoç G, Burgut R, Güneşer-Kendirli S. Evaluation of efficacy of immunotherapy in children with asthma monosensitized to Alternaria. Turk J Pediatr. 2011;53:285–94.
PubMed
Google Scholar
Horst M, Hejjaoui A, Horst V, Michel FB, Bousquet J. Double-blind, placebo-controlled rush immunotherapy with a standardized Alternaria extract. J Allergy Clin Immunol. 1990;85:460–72.
CAS
Article
PubMed
Google Scholar
Dreborg S, Agrell B, Foucard T, Kjellman NI, Koivikko A, Nilsson S. A double-blind, multicenter immunotherapy trial in children, using a purified and standardized Cladosporium herbarum preparation. I. Clinical results. Allergy. 1986;41:131–40.
CAS
Article
PubMed
Google Scholar
Malling HJ, Dreborg S, Weeke B. Diagnosis and immunotherapy of mould allergy. V. Clinical efficacy and side effects of immunotherapy with Cladosporium herbarum. Allergy. 1986;41:507–19.
CAS
Article
PubMed
Google Scholar
Przybilla B, Ruёff F, Walker A, Aberer W, Bauer CP, Berdel D, et al. Diagnose und Therapie der Bienen- und Wespengiftallergie. Allergologie. 2012;35:563–89.
Google Scholar
Dhami S, Zaman H, Varga EM, Sturm GJ, Muraro A, Akdis CA, et al. Allergen immunotherapy for insect venom allergy: a systematic review and meta-analysis. Allergy. 2017;72:342–65.
CAS
Article
PubMed
Google Scholar
Sturm GJ, Varga EM, Roberts G, Mosbech H, Bilò MB, Akdis CA, et al. EAACI guidelines on allergen immunotherapy: hymenoptera venom allergy. Arerugi. 2018;73:744–64.
CAS
Google Scholar
Hunt KJ, Valentine MD, Sobotka AK, Benton AW, Amodio FJ, Lichtenstein LM. A controlled trial of immunotherapy in insect hypersensitivity. N Engl J Med. 1978;299:157–61.
CAS
Article
PubMed
Google Scholar
Schumacher MJ, Tveten MS, Egen NB. Rate and quantity of delivery of venom from honeybee stings. J Allergy Clin Immunol. 1994;93:831–5.
CAS
Article
PubMed
Google Scholar
Dhami S, Nurmatov U, Arasi S, Khan T, Asaria M, Zaman H, et al. Allergen immunotherapy for allergic rhinoconjunctivitis: A systematic review and meta-analysis. Allergy. 2017;72:1597–631.
CAS
Article
PubMed
Google Scholar
Mari A, Ballmer-Weber BK, Vieths S. The oral allergy syndrome: improved diagnostic and treatment methods. Curr Opin Allergy Clin Immunol. 2005;5:267–73.
Article
PubMed
Google Scholar
Treudler R, Klimek L. Allergen immunotherapy in oral allergy syndrome: What kind of evidence do we have? Allergo J Int. 2019;28(2):50–6.
Article
Google Scholar
Mauro M, Russello M, Incorvaia C, Gazzola G, Frati F, Moingeon P, et al. Birch-apple syndrome treated with birch pollen immunotherapy. Int Arch Allergy Immunol. 2011;156:416–22.
Article
PubMed
Google Scholar
Treudler R, Franke A, Schmiedeknecht A, Ballmer-Weber B, Worm M, Werfel T, et al. BASALIT trial: double-blind placebo-controlled allergen immunotherapy with rBet v 1‑FV in birch-related soya allergy. Allergy. 2017;72:1243–53.
CAS
Article
PubMed
Google Scholar
Kinaciyan T, Nagl B, Faustmann S, Frommlet F, Kopp S, Wolkersdorfer M, et al. Efficacy and safety of 4 months of sublingual immunotherapy with recombinant Mal d 1 and Bet v 1 in patients with birch pollen-related apple allergy. J Allergy Clin Immunol. 2018;141:1002–8.
CAS
Article
PubMed
Google Scholar
Bussmann C, Böckenhoff A, Henke H, Werfel T, Novak N. Does allergen-specific immunotherapy represent a therapeutic option for patients with atopic dermatitis? J Allergy Clin Immunol. 2006;118:1292–8.
CAS
Article
PubMed
Google Scholar
Werfel T, Breuer K, Rueff F, Przybilla B, Worm M, Grewe M, et al. Usefulness of specific immunotherapy in patients with atopic dermatitis and allergic sensitization to house dust mites: a multi-centre, randomized, dose-response study. Allergy. 2006;61:202–5.
CAS
Article
PubMed
Google Scholar
Novak N, Bieber T, Hoffmann M, Fölster-Holst R, Homey B, Werfel T et al. Efficacy and safety of subcutaneous allergen-specific immunotherapy with depigmented polymerized mite extract in atopic dermatitis. J Allergy Clin Immunol 2012;130:925–31.e4
CAS
Article
PubMed
Google Scholar
Bae JM, Choi YY, Park CO, Chung KY, Lee KH. Efficacy of allergen-specific immunotherapy for atopic dermatitis: a systematic review and meta-analysis of randomized controlled trials. J Allergy Clin Immunol 2013;132:110–7
Article
PubMed
Google Scholar
Weschenfelder AK, Klimek L, Mülleneisen N, Renz H, Wehrmann W, Werfel T et al. Course of respiratory allergy by treatment strategy based on German routine data. Allergo J Int 2017;26:195–203
Article
PubMed
PubMed Central
Google Scholar
Klimek L, Bergmann KC, Biedermann T, Bousquet J, Hellings P, Jung K et al. Visual analogue scales (VAS): Measuring instruments for the documentation of symptoms and therapy monitoring in cases of allergic rhinitis in everyday health care: Position Paper of the German Society of Allergology (AeDA) and the German Society of Allergy and Clinical Immunology (DGAKI), ENT Section, in collaboration with the working group on Clinical Immunology, Allergology and Environmental Medicine of the German Society of Otorhinolaryngology, Head and Neck Surgery (DGHNOKHC). Allergo J Int 2017;26:16–24
Article
PubMed
PubMed Central
Google Scholar
Manzotti G, Riario-Sforza GG, Dimatteo M, Scolari C, Makri E, Incorvaia C. Comparing the compliance to a short schedule of subcutaneous immunotherapy and to sublingual immunotherapy during three years of treatment. Eur Ann Allergy Clin Immunol 2016;48:224–7
CAS
PubMed
Google Scholar