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The eQTL analysis to discover unique eGFR-related SNPs for the Taiwanese population

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Fig. 1

Data availability

The expression data of tissue-specific samples from GTEx (https://gtexportal.org/home/, GTEx Analysis V8) [5] and Nephroseq (https://v5.nephroseq.org) were used for further analyses.

References

  1. Chen YC, Wong HS, Wu MY, Chou WH, Kao CC, Chao CH, Chang WC, Wu MS (2022) Genome-wide association study for eGFR in a Taiwanese population. Clin J Am Soc Nephrol 17(11):1598–1608. https://doi.org/10.2215/CJN.02180222

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Arnold M, Raffler J, Pfeufer A, Suhre K, Kastenmuller G (2015) SNiPA: an interactive, genetic variant-centered annotation browser. Bioinformatics 31(8):1334–1336. https://doi.org/10.1093/bioinformatics/btu779

    Article  PubMed  Google Scholar 

  3. Nagai A, Hirata M, Kamatani Y, Muto K, Matsuda K, Kiyohara Y, Ninomiya T, Tamakoshi A, Yamagata Z, Mushiroda T, Murakami Y, Yuji K, Furukawa Y, Zembutsu H, Tanaka T, Ohnishi Y, Nakamura Y, BioBank Japan Cooperative Hospital G, Kubo M (2017) Overview of the BioBank Japan Project: study design and profile. J Epidemiol 27(3S):S2–S8. https://doi.org/10.1016/j.je.2016.12.005

    Article  PubMed  PubMed Central  Google Scholar 

  4. Stanzick KJ, Li Y, Schlosser P, Gorski M, Wuttke M, Thomas LF, Rasheed H, Rowan BX, Graham SE, Vanderweff BR, Patil SB, Program VAMV, Robinson-Cohen C, Gaziano JM, O’Donnell CJ, Willer CJ, Hallan S, Asvold BO, Gessner A, Hung AM, Pattaro C, Kottgen A, Stark KJ, Heid IM, Winkler TW (2021) Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals. Nat Commun 12(1):4350. https://doi.org/10.1038/s41467-021-24491-0

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Carithers LJ, Moore HM (2015) The genotype-tissue expression (GTEx) project. Biopreserv Biobank 13(5):307–308. https://doi.org/10.1089/bio.2015.29031.hmm

    Article  PubMed  PubMed Central  Google Scholar 

  6. Sheng X, Guan Y, Ma Z, Wu J, Liu H, Qiu C, Vitale S, Miao Z, Seasock MJ, Palmer M, Shin MK, Duffin KL, Pullen SS, Edwards TL, Hellwege JN, Hung AM, Li M, Voight BF, Coffman TM, Brown CD, Susztak K (2021) Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments. Nat Genet 53(9):1322–1333. https://doi.org/10.1038/s41588-021-00909-9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Mahoney ZX, Sammut B, Xavier RJ, Cunningham J, Go G, Brim KL, Stappenbeck TS, Miner JH, Swat W (2006) Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter. Proc Natl Acad Sci USA 103(52):19872–19877. https://doi.org/10.1073/pnas.0609326103

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  8. Kim ST, Ahn SY, Swat W, Miner JH (2014) DLG1 influences distal ureter maturation via a non-epithelial cell autonomous mechanism involving reduced retinoic acid signaling, Ret expression, and apoptosis. Dev Biol 390(2):160–169. https://doi.org/10.1016/j.ydbio.2014.03.014

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Uhlen M, Fagerberg L, Hallstrom BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson A, Kampf C, Sjostedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Ponten F (2015) Proteomics. Tissue-based map of the human proteome. Science 347(6220):12619. https://doi.org/10.1126/science.1260419

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by NSYSU-KMU JOINT RESEARCH PROJECT, (#NSYSUKMU 111-P21), Kaohsiung Medical University Hospital (KMUH110-0M12 and KMUH111-1M09), Kaohsiung Medical University (KMUH-DK(B)110003-1), and the Ministry of Science and Technology, Taiwan (Grant No. MOST 110-2222-E-110-008-MY3).

Funding

This research was funded by Ministry of Science and Technology, Grant no [MOST 110-2222-E-110-008-MY3], Medical University Chung-Ho Memorial Hospital, Grant no [KMUH110-0M12 and KMUH111-1M09], Kaohsiung Medical University, Grant nos [KMUH-DK(B)110003-1], [#NSYSUKMU 111-P21], National Sun Yat-sen University, Garnt no [#NSYSUKMU 111-P21].

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Authors and Affiliations

  1. Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

    Ping-Hsun Wu & Mei-Chuan Kuo

  2. Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

    Ping-Hsun Wu & Mei-Chuan Kuo

  3. Institute of Precision Medicine, College of Medicine, National Sun Yat-Sen University, No.70 Lien-Hai Rd., Kaohsiung, 80424, Taiwan

    Johnathan Lin & Sung-Huan Yu

  4. Institute of Biomedical Sciences, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan

    Johnathan Lin

  5. School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan

    Sung-Huan Yu

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  1. Ping-Hsun Wu
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Contributions

P.H. Wu was responsible for project management, data collection, and writing manuscript; J. Lin was responsible for data analysis and data interpretation; M.C. Kuo was responsible for writing the manuscript and project management; S.H. Yu was responsible for project management, data analysis, and writing manuscript.

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Correspondence to Sung-Huan Yu.

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Wu, PH., Lin, J., Kuo, MC. et al. The eQTL analysis to discover unique eGFR-related SNPs for the Taiwanese population. J Nephrol 37, 249–252 (2024). https://doi.org/10.1007/s40620-023-01793-8

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  • DOI: https://doi.org/10.1007/s40620-023-01793-8

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