Abstract
Background
People who have severe mental illness experience higher rates of long-term conditions and die on average 15–20 years earlier than people who do not have severe mental illness, a phenomenon known as the mortality gap. Long-term conditions, such as diabetes, impact health outcomes for people who have severe mental illness, however there is limited recognition of the relationship between chronic kidney disease and severe mental illness. Therefore, the aim of this scoping review was to explore the available evidence on the relationship between chronic kidney disease and severe mental illness.
Methods
Electronic databases, including MEDLINE, Embase, CINAHL, and PsycINFO were searched. The database searches were limited to articles published between January 2000–January 2022, due to significant progress that has been made in the detection, diagnosis and treatment of both SMI and CKD. Articles were eligible for inclusion if they explored the relationship between SMI and CKD (Stages 1–5) in terms of prevalence, risk factors, clinical outcomes, and access to treatment and services. Severe mental illness was defined as conditions that can present with psychosis, including schizophrenia, schizoaffective disorder, bipolar disorder, and other psychotic disorders. Thirty articles were included in the review.
Results
The included studies illustrated that there is an increased risk of chronic kidney disease amongst people who have severe mental illness, compared to those who do not. However, people who have severe mental illness and chronic kidney disease are less likely to receive specialist nephrology care, are less likely to be evaluated for a transplant, and have higher rates of mortality.
Conclusion
In conclusion, there is a dearth of literature in this area, but the available literature suggests there are significant health inequalities in kidney care amongst people who have severe mental illness. Further research is needed to understand the factors that contribute to this relationship, and to develop strategies to improve both clinical outcomes and access to kidney care.
Graphical abstract
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Introduction
People with severe mental illness (SMI) experience significant health inequalities [1,2,3]. Severe mental illnesses are defined as mental health conditions that impair a person’s ability to function in their daily life, typically conditions that can present with psychosis, such as schizophrenia and bipolar disorder [3]. People who have an SMI diagnosis die, on average, 15–20 years earlier than people who do not [4]. One issue that contributes substantially to this inequality is the high prevalence of long-term conditions among people with SMI, and the poor clinical outcomes that people with coexisting SMI and long term conditions experience in comparison to those without SMI [3].
There has been ongoing research exploring the relationship between long term conditions and SMI [4], including developing interventions to help support people with SMI manage these long term conditions, for example diabetes mellitus [5] and cardiovascular disease [6]. However, some long term conditions have received relatively limited attention in research, despite the high prevalence of risk factors and the potential significant impact on clinical outcomes for people with SMI. One long term condition that is growing in prevalence, yet receives limited recognition, is chronic kidney disease (CKD) [7]. The most common causes of CKD in the general population are diabetes mellitus and hypertension, conditions that are significantly more prevalent among people with SMI, in part because of the side-effects of antipsychotic medication [2, 8, 9].
The early stages of CKD (stages I–III) can be difficult to detect due to lack of symptoms, yet early detection and intervention can help prevent progression of CKD, development of complications, and mortality. When kidney failure is reached people require kidney replacement therapy to sustain life. Kidney replacement therapy involves replacement of the damaged kidneys through either transplantation or dialysis. These options involve a significant treatment burden, with intensive monitoring and medication regimens, alongside regular invasive treatments, dietary restrictions, and fluid restrictions for dialysis treatment [10]. Research exploring self-management of long term conditions amongst people with SMI has highlighted the difficulties these individuals have managing conditions such as diabetes mellitus, cardiovascular disease, or long term conditions in general [11, 12]. However, kidney disease poses a unique and substantial burden in relation to self-management, for example haemodialysis may require people to attend hospital three times a week for 4 h each time or restrict fluid intake to only 500 mLs per day [10]. It is poorly understood how people with SMI experience this burden or engagement in the treatment of CKD or kidney failure [13].
Despite the increased risk of CKD associated with lithium [14], a common medication for bipolar disorder and schizoaffective disorder, the high prevalence of risk factors associated with the development of CKD, CKD progression and poor outcomes, we know very little about this co-morbidity, including prevalence, outcomes, and access to services. Therefore, this scoping review is needed to describe the available literature on this relationship and present what is already known about CKD and SMI.
Aims
The aim of this review is to describe the available literature on the relationship between SMI and CKD, including prevalence, risk factors, clinical outcomes and access to treatment and specialist services.
Materials and methods
A scoping review approach, following the steps outlined in the PRISMA-ScR reporting guidelines [15], was used due to the breadth of the review questions and the need to map the available evidence. A protocol for the scoping review was created to guide the searching, screening, data extraction and synthesis process, however as scoping review protocols are not eligible for registration on the PROSPERO database this was not registered.
Information sources
Electronic databases, including MEDLINE, Embase, CINAHL, and PsycINFO were searched. The database searches were limited to articles published between January 2000–January 2022, due to significant progress that has been made in the detection, diagnosis and treatment of both SMI and CKD.
Search strategy
A search strategy was developed for each of the two conditions (CKD and SMI) which were reviewed and revised by subject librarians. The two search strategies were combined using the Boolean Operator ‘AND’ to capture literature that explored the co-existence of both CKD and SMI. Table 1 provides an exemplar search strategy used in MEDLINE.
Eligibility criteria
Articles were eligible for inclusion if they explored the relationship between SMI and CKD (Stages 1–5) in terms of prevalence, risk factors, clinical outcomes, and access to treatment and services. Severe mental illness was defined as conditions that can present with psychosis, including schizophrenia, schizoaffective disorder, bipolar disorder, and other psychotic disorders.
During the initial scoping of the literature, it was apparent that there is an extensive body of literature establishing the relationship between lithium treatment and CKD, including recent systematic literature reviews and meta-analyses [16]. To avoid duplication, articles that focused on lithium either in terms of the mechanisms, prevalence, or risk factors for CKD, were excluded unless they provided insight into other contributing risk factors. As this review is focused on CKD, articles focusing on acute kidney injury were excluded. A more comprehensive list of exclusion criteria can be found in Table 2.
Data extraction
A data extraction table was created to capture the main components of the included articles and chart the available evidence. The data items that were extracted included author names and date of publication, publication type, setting, aim, study design, start date—end date, participants, relevant findings, and conclusions. Data were extracted by CC and CC, and were reviewed and discussed by all authors to confirm accuracy and relevance.
Data synthesis
To address the aim of the scoping review, a descriptive narrative synthesis was carried out guided by the review question, providing an overview of the main areas of research to identify the current knowledge base and highlight gaps in the evidence. Due to the breadth of the review and heterogeneity of the included articles, no quantitative analysis was carried out.
Results
A total of 3581 articles were identified from the database search once duplicates were removed. Following title and abstract screening, 3365 records were excluded due to their focus on topics that were irrelevant to the review, and 216 records were identified for full text screening. Following full text screening, 185 articles were excluded. Most articles were excluded because the studies focused on the wrong patient population (n = 67) or focused on the role of lithium in CKD (n = 51). An overview of the screening process is available in Fig. 1.
Thirty studies were identified for inclusion, reported in journal articles (n = 24) and conference abstracts (n = 6). Most included studies were retrospective cohort studies using national, regional, or local databases (n = 24), and cross-sectional analysis of healthcare databases (n = 5). One article reported a qualitative study. The studies were carried out in the USA (n = 11), UK (n = 5), Taiwan (n = 4), Denmark (n = 2), France (n = 2), Australia (n = 1), Canada (n = 1), India (n = 1), Ireland (n = 1), and Israel (n = 1). One study did not report the geographical location of study, although the authors were based in the UK.
An overview of the included studies is available in Table 3.
Risk of developing CKD amongst people with SMI
Several studies examined the risk of developing CKD for people with SMI [2, 17,18,19,20,21,22,23,24]. There appears to be an increased risk for developing CKD amongst people with SMI [24], however the degree of risk may be different across SMI diagnoses. Tzur Bitan et al. [17] conducted a retrospective cohort study, comparing the prevalence of CKD amongst people with schizophrenia to matched controls without schizophrenia, over a 7-year period. Schizophrenia was found to be predictive of CKD above all other risk factors (OR = 1.62, 95% CI = 1.45–1.82, P < 0.0001) [17]. While other studies also found an increased risk of CKD amongst people with schizophrenia [21], the risk of CKD appeared to be higher for people with bipolar disorder. Smith et al. (2013) conducted a cross-sectional study exploring the prevalence of medical comorbidities in people with a diagnosis of bipolar disorder [21]. People with bipolar disorder had higher rates of CKD compared to controls (OR: 2.42, 95% CI = 2.04–2.86, P < 0.001). However, no studies carried out a direct comparison between SMI diagnoses.
The prevalence of CKD amongst people with SMI is increasing over time, according to a retrospective cohort study evaluating the prevalence of long-term conditions amongst people with SMI across a 12-year period [20]. The prevalence of CKD amongst people with SMI increased from 0.28% in 2000/2001 to 8.24% in 2011/2012. Whilst the prevalence of CKD also increased in people without SMI (from 0.26% in 2000/2001 to 4.16% in 2011/2012), the increase was at a slower rate, with the prevalence remaining lower in comparison.
Risk factors for developing CKD amongst people with SMI
Three studies explored the role psychiatric medications play in the development of CKD, specifically first- and second-generation antipsychotics [25, 26], and anticonvulsants used as mood stabilisers in bipolar disorder [27].
Second-generation antipsychotics were associated with a small to moderate increase in risk of incident CKD in a case–control cohort study[25]. This study included 21,434 CKD cases and examined the association between second-generation antipsychotic use and incident CKD. They found an increased risk of CKD both in people who were using second-generation antipsychotics at the time of the study (OR 1.26, 95% CI: 1.12–1.42), and people who had ever used second-generation antipsychotics (OR 1.24, 95% CI:1.12–1.37). There did not appear to be a dose–response relationship, as both short- and long-term prescriptions were associated with an increased risk. All second-generation antipsychotics, except for aripiprazole, were associated with an increased risk of CKD, with the highest risk associated with clozapine [OR 1.81, 95% CI: 1.22–2.69]. In contrast, a study by Wang et al. [26] found there was no significant association between first- or second-generation antipsychotic use and CKD, but there was a significantly increased risk of CKD amongst people who used a combination of first- and second-generation antipsychotics (OR 1.28, 95% CI = 1.11–1.47). However, more than 85% of their sample were receiving a combination treatment of first- and second-generation antipsychotics, limiting their ability to draw definitive conclusions about the relative risk of different antipsychotics.
The role of anticonvulsants in the risk for CKD was explored by Kessing et al. [27] who compared the rates of CKD and kidney failure among people who had bipolar disorder who were treated with lithium, anticonvulsants, and people without bipolar disorder who had never been exposed to these drugs. Anticonvulsants and other mood stabilisers were associated with an increased risk of CKD. There was a dose–response relationship with anticonvulsant treatment, as people who received over 60 prescriptions of anticonvulsants were at a higher risk of developing CKD (HR = 2.30 [95% CI, 1.53–3.44]) compared to people who had only 1–2 prescriptions (HR = 1.23 [95% CI, 0.76–1.99]; P < 0.001). A similar pattern was also observed with kidney failure, as the rates of kidney failure increased with the number of anticonvulsant prescriptions a person had received (P = 0.002). This was in comparison to lithium, which did not have a significant association with the development of kidney failure.
Outcomes for people with SMI and co-existing CKD
Suicide
One study explored suicide in the context of physical multi-morbidity and SMI. Chen et al. [28] explored the presence of physical comorbidities in the 3-month period before suicide mortality in individuals with bipolar disorder. People were more likely to have a higher comorbidity score and were more likely to have had a diagnosis of CKD in the 3-month period before they died by suicide.
Mortality
Several studies highlighted the increased risk of mortality amongst people who have co-existing SMI and kidney failure [29, 30]. Over a 5-year period people with schizophrenia have a lower risk of commencing dialysis, but a significantly higher risk of death, compared to people without schizophrenia [31]. Kimmel et al. [32] examined the association between hospitalisations with psychiatric diagnoses and death in adult patients receiving dialysis. There was an increased risk of 1-year mortality for people with kidney failure who had been hospitalised with a primary (OR 1.23, 95% CI: 1.18–1.28) or secondary psychiatric diagnosis (OR 1.09, 95% CI: 1.08–1.11), compared to those hospitalised without a psychiatric diagnosis. A study by Abbott et al. [33] found that the cumulative mortality following hospitalisation for psychosis for people who have co-existing kidney failure was 53% at 1-year follow-up, 73% at 2-year follow-up, and 84% at 3-year follow-up, and hospitalisation for psychoses was independently associated with mortality risk (HR = 1.87, 95% CI: 1.77–1.98; P < 0.001).
One study explored risk factors for mortality in people who had schizophrenia and kidney failure [34]. There was a significantly increased risk of mortality amongst people who had co-existing schizophrenia and kidney failure if they were over the age of 35, used a central venous catheter for haemodialysis access, and had heart failure. These are also associated with an increased risk of mortality in people without co-existing SMI. However, there was a reduced risk of mortality amongst people with co-existing schizophrenia and kidney failure if they had hypertension, a history of suicidal ideation or drug dependence, had ischaemic cardiovascular disease or a history of being non-compliant with treatment. These factors are associated with an escalation in care, close monitoring, and regular follow-up, which was thought to account for the reduction [34].
Most research available exploring mortality for people with co-existing SMI and CKD focused on kidney failure, as opposed to earlier stages of CKD. This may under-estimate the role that CKD plays in mortality for people with co-existing SMI, as people with SMI may not progress to kidney failure as they die before reaching the final stages [31].
Hospitalisation
McPherson et al. [35] explored the relationship between co-existing SMI and CKD, and rates of hospitalisation and repeated hospitalisation. Rehospitalisation rates are significantly increased both in people who have CKD, and people who have SMI, however there is a higher rate amongst people who have co-existing SMI and CKD (HR = 1.55, 95% CI = 1.40–1.73, P < 0.001), particularly those admitted through the emergency department. In contrast, while there was not a significantly increased risk of repeated hospitalisation for people with co-existing SMI and CKD, there was a significantly increased risk of emergent rehospitalisation. This risk was higher for those with affective disorders, such as bipolar, compared to those with schizophrenia [35, 36].
Outcomes for transplantation
Several studies that assessed clinical outcomes focussed on transplantation [37,38,39,40,41,42]. Three studies compared outcomes following kidney transplantation in people who have bipolar disorder to those who did not have bipolar disorder [37,38,39]. They found no significant differences in patient survival [37,38,39], graft survival [37,38,39], and rejection episodes [38, 39]. These similar outcomes were also seen in studies that compared transplant outcomes for people who had other SMI diagnoses, including schizophrenia [41], and psychosis [40].
None of the included studies found an increased risk of poor clinical outcomes for people who had a diagnosis of SMI and received a kidney transplantation, although there may be a risk of exacerbation of SMI symptoms in the immediate post-transplant period. Kofman et al. [39] found that following transplantation, 23 patients from their sample had a relapse of their psychiatric disorder[39], while 13 people required psychiatric hospitalisation.
Access to specialist nephrology care
Despite the increased prevalence of CKD amongst people with SMI, there is evidence that people with SMI had lower rates of accessing specialist nephrologist care [17, 31]. Hsu et al. [31] found that people with schizophrenia and co-existing kidney failure had a lower chance of receiving an appointment with a nephrologist (OR = 0.6, 95% CI 0.4–0.8, P < 0.001), of receiving an erythropoietin prescription (OR = 0.7, 95% CI 0.6–0.9, P < 0.05), and were more likely to be hospitalised within the first year of commencing dialysis (OR = 1.4, 95% CI 1.0–1.8, P < 0.05).
Most studies exploring access to nephrology care focused on access to kidney replacement therapy. People with SMI and kidney failure were less likely to have received a kidney transplant (OR = 5.43, 95% CI = 2.84–10.38, P < 0.001) [17, 19], be on the register to receive a kidney transplant (only 1.4% of people registered for a kidney transplant had a psychiatric disorder, compared to 5.3% of people who were not registered) [43] or be scheduled for a kidney transplant evaluation appointment (only 6% patients with schizophrenia, who met the eligibility criteria for a kidney transplant, were scheduled for a transplant evaluation appointment) [44] compared to people without SMI. While people with SMI were more likely to commence haemodialysis than to receive a kidney transplant [19], there is evidence that in general they are less likely to commence kidney replacement therapy [17, 31]. Tzur Bitan et al. [17] conducted a retrospective cohort study and found dialysis treatment was more commonly received among patients with CKD who did not have a comorbid schizophrenia diagnosis (11.1%), compared to CKD patients who did have the diagnosis (8.5%).
Barriers and facilitators of care
One study explored the experiences of renal nurses providing care to people with SMI receiving haemodialysis [45]. The main barriers to providing effective care were staff shortages, and a lack of staff education on mental illness. Nurses at times perceived people with SMI as difficult and challenging, particularly when they displayed aggressive behaviour. However, some facilitators included having effective communication skills and empathy. Renal nurses reported that they wanted more support from mental health teams, with a collaborative approach to patient care between teams.
Discussion
This scoping review is the first to identify and describe the available evidence on the relationship between CKD and SMI. While several studies provided insight into the risk of CKD for people with SMI, contributing factors, clinical outcomes, and access to care, overall, there is a dearth of high-quality research focussed on co-existing SMI and CKD.
The evidence demonstrates there may be a significantly increased risk of CKD for people who have SMI [17,18,19,20,21, 31]. The level of risk appears to differ depending on the SMI diagnosis [19, 21, 27], although there is little research available examining the different prevalence rates across diagnoses. Additionally, there are few studies examining the impact of risk factors for CKD amongst people who have SMI. People who have SMI are more likely to have co-morbid health conditions such as type 2 diabetes and cardiovascular disease [2], are more likely to smoke [46], have metabolic syndrome [4], and live a sedentary lifestyle [47]. These factors all contribute to the risk of CKD, however none of the studies identified in this review examined the role of these risk factors in the development of CKD amongst people with SMI.
An interesting finding from the review was the relationship between psychiatric medication, other than lithium, and the risk of CKD. Two studies implicated both first- and second-generation antipsychotics in the risk of CKD [25, 26], with mixed findings, and clozapine was associated with the highest risk. Clozapine is a highly effective atypical antipsychotic with an extensive side effect profile and, like most antipsychotic medication [9], is associated with the development of metabolic syndrome, type 2 diabetes, and cardiovascular disease [48]. Yet there is limited research acknowledging the potential impact of medication for SMI on kidney health, with the exception of lithium treatment [16].
This review also highlights potential inequality in access to specialist care for CKD among people with SMI, particularly kidney transplantation. People who have SMI appear to have similar outcomes following transplantation, with no evidence of increased rejection rates, graft loss, or mortality [38, 39, 41]. Despite this, people with SMI were less likely to receive a kidney transplant, be on the transplant register, or be assessed for transplantation [17, 43]. This inequality in access to transplantation services for people with psychiatric diagnoses has been highlighted across specialties [49]. This lack of access could result from stigma towards people with SMI, a lack of knowledge of the guidelines and evidence, and therapeutic pessimism [50]. Further research is needed to explore the role of stigma as a barrier to transplant services for those with SMI, in order to address this inequality [49].
This inequality is compounded by worse clinical outcomes overall. The evidence highlights higher rates of mortality and hospitalisation for people who have CKD and SMI [31, 33]. While people who have SMI are less likely to reach kidney failure, this is most likely a result of them dying too early for their disease to progress [31]. However, while people with SMI are not reaching the end stages of CKD, this does not mean that CKD does not contribute to the mortality gap. Cardiovascular mortality is a significant contributor to the mortality gap for people with SMI [51], while people with CKD are at a significantly raised risk of cardiovascular mortality, even in the earlier stages of the disease [30, 52].
There are a few strengths and limitations to this review. Articles were restricted to those published in the English language, meaning there may be relevant articles published in other languages that would have contributed to our understanding of the relationship between CKD and SMI, but were not accessed. Studies were included on the basis that they reported information related to people who had been diagnosed with a mental health condition classed as an SMI, however the reliability of diagnosis was not assessed. Additionally, since this is a scoping review the quality of the studies was not formally assessed using a risk of bias tool as the aim of the review was to describe the evidence, as opposed to evaluating the reliability of results. However, this review is the first to provide an overview of the literature available on the relationship between CKD and SMI. Moreover, using the scoping review methodology enabled a broad overview of the evidence to identify key gaps in the research. Table 4 illustrates some of these gaps in the evidence.
In conclusion, there is a dearth of research exploring the prevalence, risk factors, outcomes, and available care for people with SMI and CKD. There was a significant gap in relation to qualitative research, particularly studies exploring the associated care pathways for people with SMI and CKD, how this is monitored and managed in primary or secondary care mental health services, and how this compares to other long-term conditions associated with SMI, such as diabetes, cardiovascular disease and chronic obstructive pulmonary disease. The available evidence suggests there is an increased risk of CKD amongst people who have SMI, that people with SMI have poorer clinical outcomes from CKD, and that they are not accessing specialist renal care to the same degree as people without SMI. There is a need for further research in this area to fully understand this relationship and inform strategies to improve clinical outcomes and close the mortality gap.
Data availability
No new data were generated as part of this review.
References
Shiers D, Bradshaw T, Campion J (2015) Health inequalities and psychosis: time for action. Br J Psychiatry 207(6):471–473. https://doi.org/10.1192/bjp.bp.114.152595
Garriga C, Robson J, Coupland C, Hippisley-Cox J (2020) NHS Health Checks for people with mental ill-health 2013–2017: an observational study. Epidemiol Psychiatr Sci 29:e188. https://doi.org/10.1017/S2045796020001006
Network NMHI (2018) Severe mental illness (SMI) and physical health inequalities: briefing. Public Health, London
Siddiqi N, Doran T, Prady SL, Taylor J (2017) Closing the mortality gap for severe mental illness: are we going in the right direction? Br J Psychiatry 211(3):130–131. https://doi.org/10.1192/bjp.bp.117.203026
Brown JVE, Ajjan R, Alderson S, Böhnke JR, Carswell C, Doherty P, Double K, Gilbody S, Hadjiconstantinou M, Hewitt C et al (2022) The DIAMONDS intervention to support self-management of type 2 diabetes in people with severe mental illness: study protocol for a single-group feasibility study. SSM Mental Health 2:100086. https://doi.org/10.1016/j.ssmmh.2022.100086
Osborn D, Burton A, Walters K, Nazareth I, Heinkel S, Atkins L, Blackburn R, Holt R, Hunter R, King M (2016) Evaluating the clinical and cost effectiveness of a behaviour change intervention for lowering cardiovascular disease risk for people with severe mental illnesses in primary care (PRIMROSE study): study protocol for a cluster randomised controlled trial. Trials 17(1):80. https://doi.org/10.1186/s13063-016-1176-9
Bikbov B, Purcell CA, Levey AS, Smith M, Abdoli A, Abebe M, Adebayo OM, Afarideh M, Agarwal SK, Agudelo-Botero M et al (2020) Global, regional, and national burden of chronic kidney disease: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 395(10225):709–733. https://doi.org/10.1016/S0140-6736(20)30045-3
Vancampfort D, Correll CU, Galling B, Probst M, De Hert M, Ward PB, Rosenbaum S, Gaughran F, Lally J, Stubbs B (2016) Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta-analysis. World Psychiatry 15(2):166–174. https://doi.org/10.1002/wps.20309
Holt RIG (2019) Association between antipsychotic medication use and diabetes. Curr Diab Rep 19(10):96. https://doi.org/10.1007/s11892-019-1220-8
Ammirati AL (2020) Chronic kidney disease. Rev Assoc Med Bras 66:s03–s09. https://doi.org/10.1590/1806-9282.66.S1.3
Carswell C, Brown JVE, Lister J, Ajjan RA, Alderson SL, Balogun-Katung A, Bellass S, Double K, Gilbody S, Hewitt CE (2022) The lived experience of severe mental illness and long-term conditions: a qualitative exploration of service user, carer, and healthcare professional perspectives on self-managing co-existing mental and physical conditions. BMC Psychiatry 22(1):479. https://doi.org/10.1186/s12888-022-04117-5
Balogun-Katung A, Carswell C, Brown JVE, Coventry P, Ajjan R, Alderson S, Bellass S, Boehnke JR, Holt R, Jacobs R (2021) Exploring the facilitators, barriers, and strategies for self-management in adults living with severe mental illness, with and without long-term conditions: a qualitative evidence synthesis. PLoS One 16(10):e0258937. https://doi.org/10.1371/journal.pone.0258937
Cogley C, Carswell C, Bramham K, Chilcot J (2022) Chronic kidney disease and severe mental illness: addressing disparities in access to health care and health outcomes. Clin J Am Soc Nephrol 17(9):1413–1417. https://doi.org/10.2215/CJN.15691221
Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, Moher D, Peters MDJ, Horsley T, Weeks L et al (2018) PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med 169(7):467–473. https://doi.org/10.7326/M18-0850
Van Alphen AM, Bosch TM, Kupka RW, Hoekstra R (2021) Chronic kidney disease in lithium-treated patients, incidence and rate of decline. Int J Bipolar Disord 9(1):1. https://doi.org/10.1186/s40345-020-00204-2
Schoretsanitis G, de Filippis R, Brady BM, Homan P, Suppes T, Kane JM (2022) Prevalence of impaired kidney function in patients with long-term lithium treatment: a systematic review and meta-analysis. Bipolar Disord 24(3):264–274. https://doi.org/10.1111/bdi.13154
Tzur Bitan D, Krieger I, Berkovitch A, Comaneshter D, Cohen A (2019) Chronic kidney disease in adults with schizophrenia: a nationwide population-based study. Gen Hosp Psychiatry 58:1–6. https://doi.org/10.1016/j.genhosppsych.2019.01.007
Almeida OP, Hankey GJ, Yeap BB, Golledge J, Flicker L (2018) Older men with bipolar disorder diagnosed in early and later life: physical health morbidity and general hospital service use. J Affect Disord 241:269–274. https://doi.org/10.1016/j.jad.2018.08.035
Iwagami M, Mansfield KE, Hayes JF, Walters K, Osborn DP, Smeeth L, Nitsch D, Tomlinson LA (2018) Severe mental illness and chronic kidney disease: a cross-sectional study in the United Kingdom. Clin Epidemiol 10:421–429. https://doi.org/10.2147/CLEP.S154841
Reilly S, Olier I, Planner C, Doran T, Reeves D, Ashcroft DM, Gask L, Kontopantelis E (2015) Inequalities in physical comorbidity: a longitudinal comparative cohort study of people with severe mental illness in the UK. BMJ Open 5(12):e009010. https://doi.org/10.1136/bmjopen-2015-009010
Tzeng NS, Hsu YH, Ho SY, Kuo YC, Lee HC, Yin YJ, Chen HA, Chen WL, Chu WC, Huang HL (2015) Is schizophrenia associated with an increased risk of chronic kidney disease? A nationwide matched-cohort study. BMJ Open 5(1):e006777. https://doi.org/10.1136/bmjopen-2014-006777
Lally J, Gardney Sood P, Jayawardene S, Smith S, Atakan Z, Greenwood K, Murray RM, Gaughran F (2013) Prevalence and associations of chronic kidney disease (CKD) in patients with psychotic disorders. In: International congress on schizophrenia research
Smith DJ, Martin D, McLean G, Langan J, Guthrie B, Mercer SW (2013) Multimorbidity in bipolar disorder and undertreatment of cardiovascular disease: a cross sectional study. BMC Med 11:263. https://doi.org/10.1186/1741-7015-11-263
Welsh KJ, Patel CB, Fernando RC, Torres JD, Medrek SK, Schnapp WB, Brown CA, Buck DS (2012) Prevalence of bipolar disorder and schizophrenia in Houston outreach medicine, education, and social services (HOMES) clinic patients: implications for student-managed clinics for underserved populations. Acad Med 87(5):656–661. https://doi.org/10.1097/ACM.0b013e31824d4540
Højlund M, Lund LC, Herping JLE, Haastrup MB, Damkier P, Henriksen DP (2020) Second-generation antipsychotics and the risk of chronic kidney disease: a population-based case–control study. BMJ Open 10(8):e038247. https://doi.org/10.1136/bmjopen-2020-038247
Wang HY, Huang CL, Feng IJ, Tsuang HC (2018) Second-generation antipsychotic medications and risk of chronic kidney disease in schizophrenia: population-based nested case–control study. BMJ Open 8(5):e019868. https://doi.org/10.1136/bmjopen-2017-019868
Kessing LV, Gerds TA, Feldt-Rasmussen B, Andersen PK, Licht RW (2015) Use of lithium and anticonvulsants and the rate of chronic kidney disease: a nationwide population-based study. JAMA Psychiatry 72(12):1182–1191. https://doi.org/10.1001/jamapsychiatry.2015.1834
Chen PH, Tsai SY, Pan CH, Chen YL, Chang HM, Su SS, Chen CC, Kuo CJ (2021) Sex-specific risk profiles for suicide mortality in bipolar disorder: incidence, healthcare utilization and comorbidity. Psychol Med. https://doi.org/10.1017/S003329172100307X
Manjunatha N, Kumar CN, Thirthalli J, Suresha KK, Harisha DM, Arunachala U (2019) Mortality in schizophrenia: a study of verbal autopsy from cohorts of two rural communities of South India. Indian J Psychiatry 61(3):238–243. https://doi.org/10.4103/psychiatry.IndianJPsychiatry_135_19
Tonelli M, Wiebe N, Culleton B, House A, Rabbat C, Fok M, McAlister F, Garg AX (2006) Chronic kidney disease and mortality risk: a systematic review. J Am Soc Nephrol 17(7):2034. https://doi.org/10.1681/ASN.2005101085
Hsu YH, Cheng JS, Ouyang WC, Lin CL, Huang CT, Hsu CC (2015) Lower incidence of end-stage renal disease but suboptimal pre-dialysis renal care in schizophrenia: a 14-year nationwide cohort study. PLoS One 10(10):e0140510. https://doi.org/10.1371/journal.pone.0140510
Kimmel PL, Fwu CW, Abbott KC, Moxey-Mims MM, Mendley S, Norton JM, Eggers PW (2019) Psychiatric illness and mortality in hospitalized ESKD dialysis patients. Clin J Am Soc Nephrol 14(9):1363–1371. https://doi.org/10.2215/CJN.14191218
Abbott KC, Agodoa LY, O’Malley PG (2003) Hospitalized psychoses after renal transplantation in the United States: incidence, risk factors, and prognosis. J Am Soc Nephrol 14(6):1628–1635. https://doi.org/10.1097/01.asn.0000069268.63375.4a
Jackson AJ, Colombo R, Baer S, Young L, Waller J, Kheda M, Nahman S, Spearman V (2018) Risk factors for mortality in patients with schizophrenia and end-stage renal disease. J Investig Med 66:599
McPherson S, Barbosa-Leiker C, Daratha K, Short R, McDonell MG, Alicic R, Roll J, Tuttle K (2014) Association of co-occurring serious mental illness with emergency hospitalization in people with chronic kidney disease. Am J Nephrol 39(3):260–267. https://doi.org/10.1159/000360095
Germack HD, Bizhanova Z, Roberts ET (2020) Substantial hospital level variation in all-cause readmission rates among medicare beneficiaries with serious mental illness. Healthcare (Amst) 8(3):100453. https://doi.org/10.1016/j.hjdsi.2020.100453
Goswami Banerjee A, Hamel S, Weinrieb R, Dave S, Johnson V, Sawinski D, Trofe-Clark J (2019) A retrospective matched case–control study of medical and psychiatric outcomes in kidney transplant recipients with bipolar disorder. In: American transplant congress. https://doi.org/10.1111/ajt.15406
Hamel S, Sawinski D, Weinrieb R, Dave S, Trofe-Clark J (2018) Outcomes in renal transplant recipients with bipolar disorder: a large retrospective cohort. In: American transplant congress, Seattle, WA
Kofman T, Pourcine F, Canoui-Poitrine F, Kamar N, Malvezzi P, François H, Boutin E, Audard V, Lang P, Martinez F et al (2018) Safety of renal transplantation in patients with bipolar or psychotic disorders: a retrospective study. Transpl Int 31(4):377–385. https://doi.org/10.1111/tri.13078
Molnar MZ, Eason JD, Gaipov A, Talwar M, Potukuchi PK, Joglekar K, Remport A, Mathe Z, Mucsi I, Novak M et al (2018) History of psychosis and mania, and outcomes after kidney transplantation—a retrospective study. Transpl Int 31(5):554–565. https://doi.org/10.1111/tri.13127
Butler MI, McCartan D, Cooney A, Kelly PO, Ahmed I, Little D, MacHale S, Conlon P (2017) Outcomes of renal transplantation in patients with bipolar affective disorder and schizophrenia: a national retrospective cohort study. Psychosomatics 58(1):69–76. https://doi.org/10.1016/j.psym.2016.08.010
Dube G, Crew R, Tsapeppas D, Khorassani F, Wiener I (2013) Excellent outcomes of kidney transplant patients with bipolar disorder. Am J Transplant 13
Bayat S, Frimat L, Thilly N, Loos C, Briançon S, Kessler M (2006) Medical and non-medical determinants of access to renal transplant waiting list in a French community-based network of care. Nephrol Dial Transplant 21(10):2900–2907. https://doi.org/10.1093/ndt/gfl329
Boyle SM, Fehr K, Deering C, Raza A, Harhay MN, Malat G, Ranganna K, Lee DH (2020) Barriers to kidney transplant evaluation in HIV-positive patients with advanced kidney disease: a single-center study. Transplant Infect Dis 22(2):e13253. https://doi.org/10.1111/tid.13253
Alwar A, Addis G (2021) Renal nurses’ experiences of patients with severe mental health conditions receiving acute haemodialysis: a qualitative study. J Ren Care 48(3):197–206. https://doi.org/10.1111/jorc.12401
Szatkowski L, McNeill A (2015) Diverging trends in smoking behaviors according to mental health status. Nicotine Tob Res 17(3):356–360. https://doi.org/10.1093/ntr/ntu173
Stubbs B, Firth J, Berry A, Schuch FB, Rosenbaum S, Gaughran F, Veronesse N, Williams J, Craig T, Yung AR et al (2016) How much physical activity do people with schizophrenia engage in? A systematic review, comparative meta-analysis and meta-regression. Schizophr Res 176(2–3):431–440. https://doi.org/10.1016/j.schres.2016.05.017
Yuen JWY, Kim DD, Procyshyn RM, Panenka WJ, Honer WG, Barr AM (2021) A focused review of the metabolic side-effects of clozapine. Front Endocrinol (Lausanne) 12:609240. https://doi.org/10.3389/fendo.2021.609240
Cahn-Fuller KL, Parent B (2017) Transplant eligibility for patients with affective and psychotic disorders: a review of practices and a call for justice. BMC Med Ethics 18(1):72. https://doi.org/10.1186/s12910-017-0235-4
Knaak S, Mantler E, Szeto A (2017) Mental illness-related stigma in healthcare: barriers to access and care and evidence-based solutions. Healthc Manage Forum 30(2):111–116. https://doi.org/10.1177/0840470416679413
Osborn DPJ, Levy G, Nazareth I, Petersen I, Islam A, King MB (2007) Relative risk of cardiovascular and cancer mortality in people with severe mental illness from the united kingdom’s general practice research database. Arch Gen Psychiatry 64(2):242–249. https://doi.org/10.1001/archpsyc.64.2.242
Vanholder R, Massy Z, Argiles A, Spasovski G, Verbeke F, Lameire N, European Uremic Toxin Work G (2005) Chronic kidney disease as cause of cardiovascular morbidity and mortality. Nephrol Dial Transplant 20(6):1048–1056. https://doi.org/10.1093/ndt/gfh813
Funding
The authors did not receive funding to complete this review.
Author information
Authors and Affiliations
Contributions
CC drafted the work. All authors contributed to the conception and design of the work, the interpretation of data, revisions of the work and final approval of the submitted version.
Corresponding author
Ethics declarations
Conflict of interest
The authors have no conflicts or competing interests to declare.
Ethical approval
This study was a scoping review and did not involve the recruitment of participants or collection of primary data, therefore ethical approval was not necessary.
Human and animal rights
There are no human and animal rights issues to declare, as this study did not involve any human or animal participants.
Informed consent
As this was a scoping review, informed consent was not required for this as no participants were recruited and no primary data were collected.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Carswell, C., Cogley, C., Bramham, K. et al. Chronic kidney disease and severe mental illness: a scoping review. J Nephrol 36, 1519–1547 (2023). https://doi.org/10.1007/s40620-023-01599-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40620-023-01599-8