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Noncoding RNAs associated with IgA nephropathy

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Abstract

IgA nephropathy (IgAN) is one of the most common glomerulonephritides. The disease is characterized by haematuria, proteinuria, deposition of galactose-deficient IgA1 in the glomerular mesangium and mesangial hypercellularity, further leading to extracellular matrix expansion. Kidney biopsy is the gold standard for IgAN diagnosis. Due to the invasiveness of renal biopsy, there is an unmet need for noninvasive biomarkers to diagnose and estimate the severity of IgAN. Understanding the role of RNA molecules as genetic markers to target diseases may allow developing therapeutic and diagnostic markers. In this review we have focused on intrarenal, extrarenal and extracellular noncoding RNAs involved in the progression of IgAN. This narrative review summarizes the pathogenesis of IgAN along with the correlation of noncoding RNA molecules such as microRNAs, small interfering RNAs, circular RNAs and long non-coding RNAs that play an important role in regulating gene expression, and that represent another type of regulation affecting the expression of specific glycosyltranferases, a key element contributing to the development of IgAN.

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Acknowledgements

The authors are grateful to the authorities of Aarupadai Veedu Medical College and Hospital, Vinayaka Missions Research Foundation (Deemed to be University), and we would like to thank BioRender (https://biorender.com) used to create figures.

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  1. Multi-Disciplinary Centre for Biomedical Research, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission’s Research Foundation (Deemed to be University), Kirumampakkam, Puducherry, 607402, India

    Sangeetha P. Kademani, Prabhudas Nelaturi & Sambandam Ravikumar

  2. Division of Nephrology, Department of General Medicine, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission’s Research Foundation (Deemed to be University), Kirumampakkam, Puducherry, 607402, India

    K. Sathyasagar

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  1. Sangeetha P. Kademani
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Kademani, S.P., Nelaturi, P., Sathyasagar, K. et al. Noncoding RNAs associated with IgA nephropathy. J Nephrol 36, 911–923 (2023). https://doi.org/10.1007/s40620-022-01498-4

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