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Endurance training improves heart rate on-kinetics in women with subclinical hypothyroidism: a preliminary study

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Abstract

Purpose

The aim of the study was to evaluate the effect of endurance training on heart rate (HR) on-kinetics in patients with subclinical hypothyroidism (SH).

Methods

Eighteen women were randomly assigned to trained group (TG) or control group (CG). Both groups performed three tests at 50 W in a cycle ergometer for 6 min. HR kinetics was obtained during the tests and the mean response time (MRT), which is equivalent to the time taken to reach 63% of the HR at steady state, was extracted. The TG was then submitted to 12 weeks of endurance training (50 min, 3x/week, intensity between 70 and 85% of the maximum HR predicted for the age). Statistical analysis was performed by the mixed analysis of variance.

Results

At baseline, TG and CG were similar for TSH (7.7 ± 3.1 vs. 6.9 ± 3.3 mUI/L, p = 0.602, respectively) and FT4 (12.31 ± 1.51 vs. 12.20 ± 1.89 pmol/L, p = 0.889, respectively). After adjustment for body mass index and age, interactions between moment (baseline or after 12 weeks) and group (trained or control) were only significant for MRT (TG: 39.6 ± 10 to 28.9 ± 8.4 s, CG: 53.6 ± 20.3 to 55 ± 19.7 s, p = 0.001) and physical activity level (CG: 7.3 ± 0.7 to 8 ± 0.9, CG: 6.8 ± 0.8 in both moments, p = 0.005).

Conclusion

The preliminary results suggest that 12 weeks of endurance training improve HR on-kinetics and physical activity level in SH.

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Funding

This research was funded by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).

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Authors and Affiliations

  1. Faculdade de Medicina, Universidade Federal Do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil

    S. P. Almas, P. F. S. Teixeira & M. Vaisman

  2. Escola de Educação Física, Universidade Federal de Ouro Preto (UFOP), Ouro Preto, Minas Gerais, Brazil

    F. Z. Werneck & E. F. Coelho

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  1. S. P. Almas
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Correspondence to S. P. Almas.

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This study was performed in line with the principles of the Declaration of Helsinki. The research was approved by the Research Ethics Committee of FCMS-SUPREMA (No. 0164/10).

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Almas, S.P., Werneck, F.Z., Coelho, E.F. et al. Endurance training improves heart rate on-kinetics in women with subclinical hypothyroidism: a preliminary study. J Endocrinol Invest 46, 51–57 (2023). https://doi.org/10.1007/s40618-022-01882-8

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