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The impact of thyroid hormone replacement therapy on left ventricular diastolic function in patients with subclinical hypothyroidism

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Abstract

Objective

Subclinical hypothyroidism (SH) is associated with a moderately elevated risk of heart failure events among older adults. The objective of our prospective study was to assess the impact of thyroid hormone replacement therapy (HRT) with low doses of l-thyroxine (6.25–25 µg/day) on left ventricular diastolic function in patients with SH.

Materials and methods

33 patients with SH and 25 healthy controls were involved. All participants underwent standard echocardiography and Doppler imaging at baseline and, the patient group, also after a course of HRT.

Results

At baseline, patients with SH showed significantly lower E (0.79 ± 0.22 vs. 0.93 ± 0.19, p < 0.001), E/A ratio (1.19 ± 0.29 vs. 1.31 ± 0.25, p < 0.003), and higher intraventricular septum thickness (IVST) (0.99 ± 0.14 vs. 0.89 ± 0.18, p < 0.001) in comparison with healthy controls. After 6 months of therapy, the E/A ratio underwent significant increase (1.28 ± 0.21 vs. 1.19 ± 0.29, p < 0.001), while the IVS displayed a robust reduction (0.92 ± 0.16 vs. 0.99 ± 0.14, p < 0.001).

Conclusions

HRT with low-dosed l-thyroxine may improve left ventricular diastolic function in patients with SH.

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Acknowledgments

This work was supported by the Grant of the European Regional Development Fund—Project FNUSA-ICRC (No. CZ.1.05/1.1.00/02.0123).

Conflict of interest

Authors declare no conflict of interest.

Ethical standard

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008.

Informed consent

Informed consent was obtained from all patients before being included in the study.

Author information

Authors and Affiliations

  1. Lviv National Medical University, Lviv, Ukraine

    I. Shatynska-Mytsyk

  2. Central University Hospital of Asturias (HUCA), Oviedo, Asturias, Spain

    L. Rodrigo

  3. Clinica Medica I, Fondazione IRCCS Policlinico San Matteo, Università degli Studi di Pavia, Pavia, Italy

    R. Cioccocioppo

  4. Institute of Histology and Embryology, University of Ljubljana, Ljubljana, Slovenia

    D. Petrovic

  5. Department of Cardiology, Hospital for Medical Rehabilitation, Krapinske Toplice, Croatia

    N. Lakusic

  6. Faculty of Medicine, J. J. Strossmayer University of Osijek, Osijek, Croatia

    N. Lakusic

  7. Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy

    L. Compostella

  8. International Clinical Research Center, St. Anne’s University Hospital and Masaryk University, Brno, Czech Republic

    M. Novak & P. Kruzliak

Authors
  1. I. Shatynska-Mytsyk
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  2. L. Rodrigo
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  3. R. Cioccocioppo
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  4. D. Petrovic
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  5. N. Lakusic
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  6. L. Compostella
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  7. M. Novak
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  8. P. Kruzliak
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Corresponding author

Correspondence to P. Kruzliak.

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Shatynska-Mytsyk, I., Rodrigo, L., Cioccocioppo, R. et al. The impact of thyroid hormone replacement therapy on left ventricular diastolic function in patients with subclinical hypothyroidism. J Endocrinol Invest 39, 709–713 (2016). https://doi.org/10.1007/s40618-015-0262-2

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  • DOI: https://doi.org/10.1007/s40618-015-0262-2

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