Skip to main content

Advertisement

SpringerLink
Log in

Resistin, visfatin, leptin and omentin are differently related to hormonal and metabolic parameters in growth hormone-deficient children

  • Original Article
  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

Abstract

Purpose

The effect of growth hormone (GH) on adipose tissue and the role of adipokines in modulating metabolism are documented, but with discordant data. Our aim was to evaluate the impact of GH treatment on a series of selected adipokines known to have a metabolic role and poorly investigated in this setting.

Methods

This is a prospective study. Thirty-one prepubertal children (25 M, 6 F; aged 8.5 ± 1.6 years) with isolated GH deficiency treated with GH for at least 12 months and 30 matched controls were evaluated. Auxological and metabolic parameters, insulin sensitivity indexes, leptin, soluble leptin receptor, adiponectin, visfatin, resistin, omentin, adipocyte fatty acid-binding protein and retinol-binding protein-4 were evaluated before and after 12 months of treatment.

Results

At baseline, no significant difference in metabolic parameters was found between GHD children and controls, except for higher LDL cholesterol (p = 0.004) in the first group. At multivariate analysis, LDL cholesterol was independently associated with resistin (B 0.531; p = 0.002), while IGF-I was the only variable independently associated with visfatin (B 0.688; p < 0.001). After 12 months, a significant increase in fasting insulin (p = 0.008), Homa-IR (p = 0.007) and visfatin (p < 0.001) was found, with a concomitant decrease in LDL cholesterol (p = 0.015), QUICKI (p = 0.001), ISI Matsuda (p = 0.006), leptin (p = 0.015) and omentin (p = 0.003)]. At multivariate analysis, BMI was the only variable independently associated with leptin (B 0.485; p = 0.040).

Conclusions

GH treatment modifies adipokine secretion and the perturbation of some adipokine levels could contribute to the clinical and metabolic changes observed during the follow-up.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Vijayakumar A, Novosyadlyy R, Wu Y, Yakar S et al (2010) Biological effects of growth hormone on carbohydrate and lipid metabolism. Growth Horm IGF Res 20(1):1–7

    Article  CAS  PubMed  Google Scholar 

  2. Cantley J (2014) The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis. Mamm Genome 2:442–454

    Article  Google Scholar 

  3. Capalbo D, Esposito A, Di Mase R et al (2012) Update on early cardiovascular and metabolic risk factors in children and adolescents affected with growth hormone deficiency. Minerva Endocrinol 37:379–389

    CAS  PubMed  Google Scholar 

  4. Salerno M, Esposito V, Farina V et al (2006) Improvement of cardiac performance and cardiovascular risk factors in children with GH deficiency after 2 years of GH replacement therapy: an observational, open, prospective, case-control study. J Clin Endocrinol Metab 91:1288–1295

    Article  CAS  PubMed  Google Scholar 

  5. van der Sluis IM, Boot AM, Hop WC et al (2002) Long-term effects of growth hormone therapy on bone mineral density, body composition, and serum lipid levels in growth hormone deficient children: a 6-year follow-up study. Horm Res 58:207–214

    Article  PubMed  Google Scholar 

  6. Nørrelund H, Gravholt CH, Englaro P et al (1998) Increased levels but preserved diurnal variation of serum leptin in GH-deficient patients: lack of impact of different modes of GH administration. Eur J Endocrinol 138:644–652

    Article  PubMed  Google Scholar 

  7. Elimam A, Lindgren AC, Norgren S et al (1999) Growth hormone treatment downregulates serum leptin levels in children independent of changes in body mass index. Horm Res 52:66–72

    Article  CAS  PubMed  Google Scholar 

  8. Gill MS, Toogood AA, Jones J et al (1999) Serum leptin response to the acute and chronic administration of growth hormone (GH) to elderly subjects with GH deficiency. J Clin Endocrinol Metab 84:1288–1295

    CAS  PubMed  Google Scholar 

  9. Edén Engström B, Burman P, Holdstock C et al (2003) Effects of growth hormone (GH) on ghrelin, leptin, and adiponectin in GH-deficient patients. J Clin Endocrinol Metab 88:5193–5198

    Article  PubMed  Google Scholar 

  10. Hana V, Silha JV, Justova V et al (2004) The effects of GH replacement in adult GH-deficient patients: changes in body composition without concomitant changes in the adipokines and insulin resistance. Clin Endocrinol (Oxf) 60:442–450

    Article  CAS  Google Scholar 

  11. Ciresi A, Amato MC, Criscimanna A et al (2007) Metabolic parameters and adipokine profile during GH replacement therapy in children with GH deficiency. Eur J Endocrinol 156:353–360

    Article  CAS  PubMed  Google Scholar 

  12. López-Siguero JP, López-Canti LF, Espino R et al (2011) Effect of recombinant growth hormone on leptin, adiponectin, resistin, interleukin-6, tumor necrosis factor-α and ghrelin levels in growth hormone-deficient children. J Endocrinol Invest 34:300–306

    Article  PubMed  Google Scholar 

  13. Growth Hormone Research Society (2000) Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. J Clin Endocrinol Metab 85:3990–3993

    Google Scholar 

  14. Greulich W, Pyle S (1959) Radiographic atlas of skeletal development of the hand and wrist, 2nd edn. Stanford University Press, Stanford

    Google Scholar 

  15. Matthews DR, Hosker JP, Rudenski AS et al (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419

    Article  CAS  PubMed  Google Scholar 

  16. Katz A, Nambi SS, Mather K et al (2000) Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85:2402–2410

    Article  CAS  PubMed  Google Scholar 

  17. Matsuda M, DeFronzo RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22:1462–1470

    Article  CAS  PubMed  Google Scholar 

  18. Shuldiner AR, Yang R, Gong DW (2001) Resistin, obesity and insulin resistance–the emerging role of the adipocyte as an endocrine organ. N Engl J Med 345:1345–1346

    Article  CAS  PubMed  Google Scholar 

  19. Meazza C, Elsedfy HH, Pagani S et al (2014) Metabolic parameters and adipokine profile in growth hormone deficient (GHD) children before and after 12-month GH treatment. Horm Metab Res 46:219–223

    CAS  PubMed  Google Scholar 

  20. Svensson J, Herlitz H, Lundberg PA et al (2005) Adiponectin, leptin, and erythrocyte sodium/lithium countertransport activity, but not resistin, are related to glucose metabolism in growth hormone-deficient adults. J Clin Endocrinol Metab 90:2290–2296

    Article  CAS  PubMed  Google Scholar 

  21. Nozue H, Kamoda T, Matsui A (2007) Serum resistin concentrations in growth hormone-deficient children during growth hormone replacement therapy. Metabolism 56:1514–1517

    Article  CAS  PubMed  Google Scholar 

  22. Ciresi A, Amato MC, Giordano C (2015) Reduction in insulin sensitivity and inadequate β-cell capacity to counteract the increase in insulin resistance in children with idiopathic growth hormone deficiency during 12 months of growth hormone treatment. J Endocrinol Invest 38:351–359

    Article  CAS  PubMed  Google Scholar 

  23. Heptulla RA, Boulware SD, Caprio S et al (1997) Decreased insulin sensitivity and compensatory hyperinsulinemia after hormone treatment in children with short stature. J Clin Endocrinol Metab 82:3234–3238

    CAS  PubMed  Google Scholar 

  24. Rauch F, Westermann F, Englaro P et al (1998) Serum leptin is suppressed by growth hormone therapy in growth hormone-deficient children. Horm Res 50:18–21

    Article  CAS  PubMed  Google Scholar 

  25. Fukuhara A, Matsuda M, Nishizawa M et al (2005) Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 307:426–430

    Article  CAS  PubMed  Google Scholar 

  26. Petelin A, Bizjak M, Černelič-Bizjak M et al (2014) Low-grade inflammation in overweight and obese adults is affected by weight loss program. J Endocrinol Invest 37(8):745–755

    Article  CAS  PubMed  Google Scholar 

  27. Li ZP, Zhang M, Gao J et al (2014) Study of the correlation between growth hormone deficiency and serum leptin, adiponectin, and visfatin levels in adults. Genet Mol Res 13:4050–4056

    Article  CAS  PubMed  Google Scholar 

  28. Ciresi A, Amato MC, Pizzolanti G et al (2015) Serum visfatin levels in acromegaly: correlation with disease activity and metabolic alterations. Growth Horm IGF Res 25:240–246

    Article  CAS  PubMed  Google Scholar 

  29. Kralisch S, Fasshauer M (2013) Adipocyte fatty acid binding protein: a novel adipokine involved in the pathogenesis of metabolic and vascular disease? Diabetologia 56(1):10–21

    Article  CAS  PubMed  Google Scholar 

  30. Graham TE, Yang Q, Blüher M et al (2006) Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med 354:2552–2563

    Article  CAS  PubMed  Google Scholar 

  31. von Eynatten M, Humpert PM (2008) Retinol-binding protein-4 in experimental and clinical metabolic disease. Expert Rev Mol Diagn 8:289–299

    Article  Google Scholar 

  32. Lanes R, Soros A, Gunczler P et al (2006) Growth hormone deficiency, low levels of adiponectin, and unfavorable plasma lipid and lipoproteins. J Pediatr 149:324–329

    Article  CAS  PubMed  Google Scholar 

  33. Jaikanth C, Gurumurthy P, Cherian KM et al (2013) Emergence of omentin as a pleiotropic adipocytokine. Exp Clin Endocrinol Diabetes 121:377–383

    Article  CAS  PubMed  Google Scholar 

  34. Li XP, Zeng S, Wang M et al (2014) Relationships between serum omentin-1, body fat mass and bone mineral density in healthy Chinese male adults in Changsha area. J Endocrinol Invest 37(10):991–1000

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

Author information

Authors and Affiliations

  1. Section of Cardio-Respiratory and Endocrine-Metabolic Diseases, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Piazza delle Cliniche 2, 90127, Palermo, Italy

    A. Ciresi, G. Pizzolanti, M. Leotta, V. Guarnotta, G. Teresi & C. Giordano

Authors
  1. A. Ciresi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Pizzolanti
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Leotta
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. Guarnotta
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. Teresi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. Giordano
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C. Giordano.

Ethics declarations

Conflict of interest

All authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

Ethical approval

All procedures performed were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent for the scientific use of the data was obtained from both the participants included in the study and their parents.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ciresi, A., Pizzolanti, G., Leotta, M. et al. Resistin, visfatin, leptin and omentin are differently related to hormonal and metabolic parameters in growth hormone-deficient children. J Endocrinol Invest 39, 1023–1030 (2016). https://doi.org/10.1007/s40618-016-0475-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40618-016-0475-z

Keywords

Search

Navigation