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The impact of follicular fluid adiponectin and ghrelin levels based on BMI on IVF outcomes in PCOS

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Abstract

Purpose

This study aimed at evaluating the effects of polycystic ovary syndrome (PCOS) and body mass index (BMI) on follicular fluid (FF) adiponectin and ghrelin levels, and on in vitro fertilization outcomes in patients who underwent controlled ovarian hyperstimulation.

Methods

This prospective cross-sectional study was performed with a total of 120 primary infertile women [group 1; non-PCOS = 60 (BMI <25 = 30, BMI ≥25 = 30) and group 2; PCOS = 60 (BMI <25 = 30, BMI ≥25 = 30)]. On the day of oocyte pickup, FF samples were collected.

Results

The FF adiponectin levels were lower in the lean PCOS group than the lean non-PCOS group (p = 0.001), and these levels were lower in the overweight non-PCOS group compared to lean non-PCOS group (0.001). However, there was no difference in the FF ghrelin levels between the groups. Additionally, we could not find a relationship between clinical pregnancy and adiponectin and ghrelin levels.

Conclusion

The FF adiponectin and ghrelin levels have no effects on clinical pregnancy in PCOS. Therefore, further studies are needed to elucidate this issue.

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Authors and Affiliations

  1. Konya Education and Research Hospital, Konya, Turkey

    H. A. Inal

  2. Dr. Zekai Tahir Burak Women’s Health Research and Education Hospital, Ankara, Turkey

    N. Yilmaz, A. S. Oruc & H. Timur

  3. Medical Faculty, Hitit University, Corum, Turkey

    U. Gorkem

Authors
  1. H. A. Inal
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  2. N. Yilmaz
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  3. U. Gorkem
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  4. A. S. Oruc
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  5. H. Timur
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Correspondence to H. A. Inal.

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This study was approved by the local ethics committee and the institutional review board.

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Written informed consent was obtained from all volunteers.

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Inal, H.A., Yilmaz, N., Gorkem, U. et al. The impact of follicular fluid adiponectin and ghrelin levels based on BMI on IVF outcomes in PCOS. J Endocrinol Invest 39, 431–437 (2016). https://doi.org/10.1007/s40618-015-0392-6

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  • DOI: https://doi.org/10.1007/s40618-015-0392-6

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