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Early Life Disadvantage and the Risk of Depressive Symptoms among Young Black Women

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Abstract

Overview

We examined the association between early-life socioeconomic disadvantage and depressive symptoms in adulthood and assessed whether social factors in adulthood modify the association.

Methods

The 11-item Center for Epidemiologic Studies-Depression Scale (CES-D) assessed adult depressive symptoms among 1612 Black women and other participants with a uterus (hereafter participants) in the Study of Environment, Lifestyle and Fibroids. Baseline self-reported childhood factors (i.e., parents in the household, mother’s educational attainment, food insecurity, neighborhood safety, childhood income, and quiet bedroom for sleep) were included in a latent class analysis to derive an early life disadvantage construct. Multivariable log-binomial models estimated the association between early life disadvantage and adult depressive symptoms. Potential effect modifiers included adult educational attainment, social support, and financial difficulty.

Results

Participants classified as having high early life disadvantage had 1.34 times (95% CI: 1.20, 1.49) the risk of high depressive symptoms than those in the low early life disadvantage class after adjusting for age, first born status, and childhood health. Adult educational attainment and social support modified the association.

Conclusion

Early life disadvantage increased the risk of depressive symptoms in adulthood. Participants with at least some college education and with high social support had greater risk than those with less than college education and low social support, respectively. Thus, the mental health of Black women and other participants with a uterus exposed to early life disadvantage do not necessarily benefit from higher education or from social support.

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Data Availability

Access to the data used in this study may be available upon request.

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Acknowledgements

The authors would like to thank Jennifer M. Woo, Ph.D., M.P.H., a Fellow — IRTA Postdoctoral at the National Institute of Environmental Health Sciences for her review of the manuscript.

Funding

This research was funded by the extramural program of the National Institute of Environmental Health Sciences (R01-ES028235-S1). The research was also supported in part by the Intramural Research Program of the National Institute of Environmental Health Sciences, and funding also came from the American Recovery and Reinvestment Act funds designated for NIH research.

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The senior author (Anissa I. Vines) acquired the funding and conceptualized the initial plan for the sub-study. The first (Chantel Martin), second (Lea Ghastine), and senior author (Anissa I. Vines) contributed to the manuscript’s analysis plan and the co-writing of the initial draft of the manuscript. Material preparation and data collection were provided by (Donna Baird, Lauren Wise, Ganesa Wegienka). Analyses were performed by Chantel Martin with support from Lea Ghastine. All authors contributed scholarly input, interpretation of findings, and feedback on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Anissa I. Vines.

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The parent study was reviewed and approved by the Institutional Review Board at the National Institute of Environmental Health Sciences (NIEHS) and Henry Ford Health System. This is an observational study. The Institutional Review Board at the University of North Carolina at Chapel Hill has confirmed that no ethical approval is required.

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The authors declare no competing interests.

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Martin, C.L., Ghastine, L., Wegienka, G. et al. Early Life Disadvantage and the Risk of Depressive Symptoms among Young Black Women. J. Racial and Ethnic Health Disparities 11, 1819–1828 (2024). https://doi.org/10.1007/s40615-023-01654-x

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