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HIV Dynamics With Immune Responses: Perspectives From Mathematical Modeling

  • Virology (A Nicola, Section Editor)
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Abstract

Purpose of Review

Human immunodeficiency virus (HIV) has infected over 36 million individuals worldwide and presents a tremendous public health concern, yet much remains unknown about the effect of immune responses on infection. In this review, we discuss the current status of mathematical modeling of HIV-immune system dynamics and how advances in modeling approaches have contributed to our understanding of the role of immune responses in virus infection.

Recent Findings

Recent advances provide important quantitative findings about CD8+ T cell and antibody responses. Specifically, these models explain important dynamical features such as the intracellular eclipse phase, and they estimate immune escape rates, the timing of MHC downregulation, and the proportion of virus in antibody-viral complexes.

Summary

Models of HIV-immune system dynamics, validated with experimental data, advance our quantitative understanding of infection and can generate hypotheses for further experiments. Greater insight on immune responses in HIV infection dynamics can lead to the development of vaccines and ultimately a cure for this infection.

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References

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Acknowledgments

The authors thank A. T. Dawes, R. Tyson, and C. A. Cobbold for careful reading of the manuscript and helpful comments. This work is supported by NSF grant DMS-1616299 (to NKV), a grant from the Association for Women in Mathematics (to EJS), and an international research award from Washington State University (to EJS).

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Authors and Affiliations

  1. Department of Mathematics and Statistics, Washington State University, P. O. Box 643113, Pullman, WA, 99164, USA

    Elissa J. Schwartz

  2. School of Biological Sciences, Washington State University, P.O. Box 644236, Pullman, WA, 99164, USA

    Elissa J. Schwartz, Karin R. H. Biggs, Clayton Bailes & Kari A. Ferolito

  3. Department of Mathematics and Statistics, University of Missouri–Kansas City, Kansas City, MO, 64110, USA

    Naveen K. Vaidya

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  1. Elissa J. Schwartz
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Correspondence to Elissa J. Schwartz.

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Schwartz, E.J., Biggs, K.R.H., Bailes, C. et al. HIV Dynamics With Immune Responses: Perspectives From Mathematical Modeling. Curr Clin Micro Rpt 3, 216–224 (2016). https://doi.org/10.1007/s40588-016-0049-z

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