Dear Editor,

We would like to share ideas on the publication “Impact of prior SARS-COV-2 infection and vaccination on COVID-19 hospital admission and mortality amongst nursing home residents [1].” The effectiveness of COVID-19 vaccinations and prior SARS-CoV-2 outbreaks in reducing hospitalization and mortality among nursing home residents (NHRs) was examined by Espaa et al. According to Espaa et al., SARS-CoV-2 episodes occurring before vaccination result in a significant decrease in hospitalization and fatality rates. Additionally, the efficiency of existing vaccinations against severe COVID-19 disease in NHRs is still high. In the months that follow, the protection that vaccinations provide seems to diminish [1]. For the patients undergoing aggressive chemotherapy, there was evidence of variation in response. The observation that vaccination against infection produced stronger immune responses in vaccine recipients than acute SARS-CoV-2 infection underscored the significance of vaccination, even in those who had already received the disease [1]. Therefore, a silent COVID-19 must be ruled out if neither the most recent clinical signals nor the most recent clinical markers are present in the current report [2]. A simple question to ask is whether any of the vaccine recipients had a history of COVD that is asymptomatic. It has still to be established whether the numerous COVID-19 shots available to cases who have received vaccinations would have any bearing on the result. Additionally, genetic differences seem to affect how a person’s immune system reacts to the anti-SARS-Co-V2 vaccine [3]. However, before the results can be confirmed, more clinical study will be needed.