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A narrative review on mild behavioural impairment: an exploration into its scientific perspectives

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Abstract

In clinical practice, the admission of patients with late-onset psychological and behavioural symptoms is frequent, regardless of the presence or absence of cognitive decline. These symptoms commonly occur in the prodromal stage of dementia and can precede the onset of dementia. While the concept of Mild Cognitive Impairment (MCI) -which is defined as a level of cognitive impairment insufficient to impact daily functioning- is well established, the notion of Mild Behavioural Impairment (MBI) is not yet widely recognized. However, studies have demonstrated that the presence of MBI in both cognitively normal patients and individuals with MCI is associated with an increased risk of dementia progression. Thus, MBI may serve as a neurobehavioral indicator of pre-dementia risk states. This narrative review aims to discuss the evolution of the term, the relevant clinical aspects, and potential biomarkers that may contribute to the clinical definition of MBI. The objective is to assist clinicians in recognizing the diagnosis and differentiating it from psychiatric syndromes, as well as identifying possible etiologies of neurodegeneration.

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Authors and Affiliations

  1. Department of Integration, Intermediate Care Programme, AUSL Bologna, Bologna, Italy

    Mariagiovanna Cozza

  2. Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Santa Maria della Misericordia Hospital, Piazzale Gambuli 1, 06132, Perugia, Italy

    Virginia Boccardi

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  1. Mariagiovanna Cozza
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  2. Virginia Boccardi
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MC contributed to the study conception and design. All authors performed material preparation and data collection. MC wrote the first draft of the manuscript and VB commented on previous versions. VB revised the manuscript. VB supervised the review. All authors read and approved the final manuscript.

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Correspondence to Virginia Boccardi.

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Cozza, M., Boccardi, V. A narrative review on mild behavioural impairment: an exploration into its scientific perspectives. Aging Clin Exp Res 35, 1807–1821 (2023). https://doi.org/10.1007/s40520-023-02472-1

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