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Neighborhood social capital and incidence and mortality of prostate cancer: a Swedish cohort study

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Abstract

Background

There is a growing interest in the contextual effect of neighborhood linking social capital on different health outcomes, including cancer.

Aims

To examine associations between neighborhood linking social capital and incidence and mortality of prostate cancer.

Method

This cohort study was based on national registers. Between 2002 and 2015, we included 1,196,563 men aged 50 years and above in the analyses. Multilevel logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI) for the association between exposure and outcome, adjusting for potential confounding factors.

Results

The total incidence of prostate cancer and mortality in patients with prostate cancer were 8.22 (per 100) and 1.80 (per 100), respectively, during the follow-up period. Individuals living in neighborhoods with low (OR 0.90; 95% CI 0.88–0.93) and intermediate (OR 0.94; 95% CI 0.92–0.96) linking social capital were less likely to be diagnosed with prostate cancer than those living in neighborhoods with high linking social capital. Opposite effects were observed for mortality; prostate cancer patients living in neighborhoods with low (OR 1.15; 95% CI 1.08–1.23) and intermediate (OR 1.09; 95% CI 1.03–1.14) linking social capital were more likely to die from prostate cancer than those in neighborhoods with high linking social capital.

Conclusions

Lower neighborhood linking social capital was associated with lower incidence but higher mortality in patients with prostate cancer. These findings suggest that men living in neighborhoods with low linking social capital may need additional surveillance for prostate cancer.

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Data availability

The data used in the present study cannot be shared as it is based on data obtained from Swedish population-based registers with national coverage.

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Funding

This research was supported by KAKENHI (Grant Number: 18K11143 to Tsuyoshi Hamano). This work was also supported by the Swedish Research Council to Kristina Sundquist. The funders had no role in the analysis, interpretation of data, or preparation of the manuscript.

Author information

Authors and Affiliations

  1. Department of Sports Sociology and Health Sciences, Faculty of Sociology, Kyoto Sangyo University, Motoyama Kamigamo, Kita-ku, Kyoto, Japan

    Tsuyoshi Hamano

  2. Center for Community-Based Health Research and Education (CoHRE), Organization for the Promotion of Project Research, Shimane University, Izumo, Japan

    Tsuyoshi Hamano, Jan Sundquist & Kristina Sundquist

  3. Center for Primary Health Care Research, Lund University, Malmö, Sweden

    Xinjun Li, Jan Sundquist & Kristina Sundquist

  4. Department of Family Medicine and Community Health, Department of Population Health Science and Policy, Icahn School of Medicine At Mount Sinai, New York, NY, USA

    Jan Sundquist & Kristina Sundquist

Authors
  1. Tsuyoshi Hamano
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  2. Xinjun Li
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  3. Jan Sundquist
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  4. Kristina Sundquist
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Contributions

TH, XL, JS, KS worked on the conception of the study; XL performed the statistical analyses; TH, XL, JS, KS contributed to data interpretation; TH drafted the paper. All authors have read and approved the final manuscript.

Corresponding author

Correspondence to Tsuyoshi Hamano.

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Conflict of interest

The authors have no confict of interest to disclose.

Ethical approval

This study was approved by the Regional Ethical Review Board in Lund.

Statement of human and animal rights

The study have been approved by the appropriate institutional research ethics committee and have been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Participant consent was not obtained as the study was based on registry information.

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Hamano, T., Li, X., Sundquist, J. et al. Neighborhood social capital and incidence and mortality of prostate cancer: a Swedish cohort study. Aging Clin Exp Res 33, 3333–3342 (2021). https://doi.org/10.1007/s40520-021-01852-9

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  • DOI: https://doi.org/10.1007/s40520-021-01852-9

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