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Disability-adjusted life expectancy lost due to pain severity and usual analgesic treatment among older adults with osteoarthritis in Spain

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Abstract

Background

Osteoarthritis (OA) is a seriously debilitating disease, which prevalence is growing in aging population becoming a substantial burden (BoD) to society.

Aim

To assess disability-adjusted life expectancy (DALE) lost by pain severity and usual analgesic treatment among OA adults 65 + year in Spain.

Methods

The National Health Survey, a large, nationally representative, cross-sectional general health survey administered to 23,089 individuals was the data source. Data on subjects of 65 + years with a self-reported physician diagnosis of OA were analysed. Records were cross-classified by pain severity (no pain/mild pain, moderate pain and severe pain) and use of usual analgesics. DALE lost was used as a summary measure of BoD and expressed as both number of years of healthy life-expectancy lost due to disability and percentage of life-expectancy lost.

Results

3389 records were analysed [women 73.3%; age 77.4 (SD 7.5) years]. Older OA patients showed a mean (95% CI) DALE loss of 3.5 (3.3–3.7) years, that represented on average a loss of 35.6% (33.8–37.4) as a percentage of life expectancy. Higher pain severity and analgesic treatment was statistically linked to more years of DALE lost; from 2.8 (2.3–3.2), in no/mild, to 9.0 (8.6–9.4) years in severe pain, and from 32.2% (27.5–36.9) to 90.9% (86.5–95.3) of life expectancy, respectively.

Discussion

In Spain, older adults with moderate to severe OA pain receiving usual analgesics showed a substantial BoD in terms of years of DALE lost and percentage of life expectancy lost.

Conclusions

Patients with treated moderate to severe pain showed a more significant burden in term of DALE lost despite analgesic treatment, which apparently fails to meet pain management needs.

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Data availability

Data and analysis are available upon request.

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Authors and Affiliations

  1. Universidad Carlos III, Madrid, Spain

    Natalia Llopart-Carles, Sofía García-López & Javier Rejas-Gutierrez

  2. Department of Health Economics and Outcomes Research, Pfizer, SLU, Avda. de Europa, 20-B, Alcobendas, 28108, Madrid, Spain

    Javier Rejas-Gutierrez

Authors
  1. Natalia Llopart-Carles
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  2. Sofía García-López
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  3. Javier Rejas-Gutierrez
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Corresponding author

Correspondence to Javier Rejas-Gutierrez.

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The author declares that they have no conflict of interest.

Ethics approval

The analysis carried out in this study used aggregate dated available in the public domain only; thus, de-identification was guaranteed to prevent anyone’s personal identity from being revealed. Therefore, studies such as this one are exempt from IRB review and from classification by the Spanish Agency of Medicines and Medical Devices (AEMPS) according to current regulations for post-authorisation observational studies (https://www.aemps.gob.es/investigacionClinica/medicamentos/estudiosPostautorizacion.htm#norEstatal).

Informed consent

The confidentiality of the records (anonymous and dissociated) was respected according to the existing Spanish Law on Personal Data Protection (Law 15/1999, of 13 December 1999, on Personal Data Protection). Individuals included in the ENSE survey participated voluntarily and gave their personal consent prior to their participation in the survey (see details on survey implementation at: https://www.mscbs.gob.es/estadEstudios/estadisticas/encuestaNacional/encuesta2017.htm).

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Llopart-Carles, N., García-López, S. & Rejas-Gutierrez, J. Disability-adjusted life expectancy lost due to pain severity and usual analgesic treatment among older adults with osteoarthritis in Spain. Aging Clin Exp Res 33, 1285–1295 (2021). https://doi.org/10.1007/s40520-020-01630-z

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