Skip to main content

Advertisement

SpringerLink
Log in

Differential impact of endurance, strength, or combined training on quality of life and plasma serotonin in healthy older women

  • Original Article
  • Published:
Aging Clinical and Experimental Research Aims and scope Submit manuscript

Abstract

Aging is associated with a progressive decline in physical and neurophysiological functions, and some studies suggest that cerebral serotonin is decreased in older adults. These factors contribute to reduced ability to perform daily activities, influencing quality of life (QoL). Regular physical activity has demonstrated important benefits in reversing ageing effects; however, little is known whether different training protocols might induce differential effects on QoL. The aim of this study was to verify the effects of different types of training on QoL and its relation with plasma serotonin in healthy older women. Forty-eight older women were randomly assigned in four groups: Strength Training (ST), Endurance Training (ET), Combined Training (CT), and Control Group (CG) which was instructed not to engage in any physical exercise during the study time. Participants underwent 12 weeks of training twice a week. Plasma serotonin and a scoring system questionnaire SF-36 for evaluation of QoL were assessed at baseline and after the completion of training protocols. When comparing pre- and post-training periods all trained groups showed improvement in QoL, but the CT improved more domains. Plasma serotonin was significantly lower in the ST and in the CT groups in comparison with controls after the 12-week training. Significant correlations of plasma serotonin with physical functioning, role-physical, general health, vitality, and mental health were observed. CT resulted in higher amelioration in QoL, in comparison with ET or ST only. All training protocols induced significant reductions in peripheral serotonin levels, which were negatively correlated with improvements in QoL.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. United Nations, Department of Economic and Social Affairs, Population Division (2017) World population ageing WPA-2017 report ST/ESA/SER.A/408

  2. Melancon MO, Lorrain D, Dionne IJ (2014) Exercise and sleep in aging: emphasis on serotonin. Pathol Biol 62:276–283

    CAS  PubMed  Google Scholar 

  3. Bouaziz W, Vogel T, Schmitt E et al (2016) Health benefits of aerobic training programs in adults aged 70 and over: a systematic review. Arch Gerontol Geriatr 69:110–127

    PubMed  Google Scholar 

  4. Herregodts P, Ebinger G, Michotte Y (1991) Distribution of monoamines in human brain—evidence for neurochemical heterogeneity in subcortical as well as in cortical areas. Brain Res 542:300–306

    CAS  PubMed  Google Scholar 

  5. Konradi C, Kornhuber J, Sofic E et al (1992) Variations of monoamines and their metabolites in the human brain putamen. Brain Res 579:285–290

    CAS  PubMed  Google Scholar 

  6. Von Linstow CU, Severino M, Metaxas A et al (2017) Effect of aging and Alzheimer’s disease-like pathology on brain monoamines in mice. Neurochem Int 108:238–245

    Google Scholar 

  7. Van der Vusse GJ, Reneman RS (1996)) Lipid metabolism in muscle. In: Rowell LB, Shepherd JT (eds) Handbook of physiology Sect. 12 exercise: regulation and integration of multiple systems. Oxford University Press, New York, pp 952–994

    Google Scholar 

  8. Sasaki E, Saito K, Ohta Y et al (1991) Specific binding of L-tryptophan to serum albumin and its function in vivo. Adv Exp Med Biol 294:611–614

    CAS  PubMed  Google Scholar 

  9. Melancon MO, Lorrain D, Dionne IJ (2014) Changes in markers of brain serotonin activity in response to chronic exercise in senior men. Appl Physiol Nutr Metab 39:1250–1256

    CAS  PubMed  Google Scholar 

  10. Bidonde J, Busch AJ, Schachter CL et al (2017) Aerobic exercise training for adults with fibromyalgia. Cochrane Database Syst Rev 6:CD012700

    PubMed  Google Scholar 

  11. Petruzzello SJ, Landers DM, Hatfield BD et al (1991) A meta-analysis on the anxiety-reducing effects of acute and chronic exercise. Sports Med 11:143–182

    CAS  PubMed  Google Scholar 

  12. Yuan TF, Paes F, Arias-Carrión O et al (2015) Neural mechanisms of exercise: anti-depression, neurogenesis, and serotonin signaling. CNS Neurol Disord Drug Targets 10:1307–1311

    Google Scholar 

  13. Schroecksnadel K, Sarcletti M, Winkler C et al (2008) Quality of life and immune activation in patients with HIV-infection. Brain Behav Immun 22:881–889

    CAS  PubMed  Google Scholar 

  14. Yoshikawa Y, Ohmaki E, Kawahata H et al (2018) Beneficial effect of laughter therapy on physiological and psychological function in elders. Nurs Open 6:93–99

    PubMed  PubMed Central  Google Scholar 

  15. Borg G (1970) Perceived exertion as an indicator of somatic stress. Scand J Rehabil Med 2:92–98

    CAS  PubMed  Google Scholar 

  16. Gearhart RF Jr, Goss FL, Lagally KM et al (2002) Ratings of perceived exertion in active muscle during high-intensity and lowintensity resistance exercise. J Strength Cond Res/NatlStrength Cond Assoc 16:87–91

    Google Scholar 

  17. Lagally KM, Robertson RJ, Gallagher KI et al (2002) Ratings of perceived exertion during low- and highintensity resistance exercise by young adults. Percept Mot Skills 94:723–731

    PubMed  Google Scholar 

  18. Karvonen M, Kentala K, Mustala O (1957) The effects of training on heart rate: a longitudinal study. Ann Med Exp Biol Fenn 35:307–315

    CAS  PubMed  Google Scholar 

  19. Chtara M, Chamari K, Chaouachi M et al (2005) Effects of intra-session combined endurance and strength training sequence on aerobic performance and capacity. Br J Sports Med 39:555–560

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Graciano MIG, Lehfeld NAS (2010) Estudo socioeconômico: indicadores e metodologia numa abordagem contemporânea. Revista Serviço Social Saúde UNICAMP Campinas 9:157–185

    Google Scholar 

  21. Forlenza OV, Caramelli P (2014) Neuropsiquiatria geriátrica. Geriatric neuropsychiatry, Atheneu, Rio de Janeiro

    Google Scholar 

  22. Ciconelli RM, Ferraz MB, Santos W et al (1999) Tradução para a língua portuguesa e validação do questionário genérico de avaliação de qualidade de vida SF-36 (Brasil SF-36)/Brazilian–Portuguese version of the SF-36. A reliable and valid quality of life outcome measure. Rev Bras Reumatol 39:143–150

    Google Scholar 

  23. Brunoni L, Schuch FB, Dias CP et al (2015) Treinamento de força diminui os sintomas depressivos e melhora a qualidade de vida relacionada a saúde em idosas. Rev Bras Edu Fis Esporte 29:189–196

    Google Scholar 

  24. McAuley E, Doerksen SE, Morris KS et al (2008) Pathways from physical activity to quality of life in older women. Ann Behav Med 36:13–20

    PubMed  PubMed Central  Google Scholar 

  25. Mosallanezhad Z, Salavati M, Sotoudeh GR et al (2014) Walking habits and health-related factors in 75-year-old Iranian women and men. Arch Gerontol Geriatr 58:320–326

    PubMed  Google Scholar 

  26. Azpiazu Garrido M, Cruz Jentoft A, Villagrasa Ferrer JR et al (2002) Factors related to perceived poor health condition or poor quality of life among those over age 65. Rev Esp Salud Pública 76:683–699

    PubMed  Google Scholar 

  27. Mota J, Ribeiro J, Carvalho J et al (2006) Atividade física e qualidade de vida associada à saúde em idosos participantes e não participantes em programas regulares de atividade física. Rev Bras Edu Fis Esporte 20:219–225

    Google Scholar 

  28. Slimani M, Ramirez-Campillo R, Paravlic A et al (2018) The effects of physical training on quality of life, aerobic capacity, and cardiac function in older patients with heart failure: a meta-analysis. Front Physiol 9:1564

    PubMed  PubMed Central  Google Scholar 

  29. Strüder HK, Weicker H (2001) Physiology and pathophysiology of the serotonergic system and its implications on mental and physical performance. Part I. Int J Sports Med 22:467–481

    PubMed  Google Scholar 

  30. Chaouloff F, Laude D, Elghozi JL (1989) Physical exercise: evidence for differential consequences of tryptophan on 5-HT synthesis and metabolism in central serotonergic cell bodies and terminals. J Neural Transm 78:121–130

    CAS  PubMed  Google Scholar 

  31. Wipfli B, Landers D, Nagoshi C et al (2011) An examination of serotonin and psychological variables in the relationship between exercise and mental health. Scand J Med Sci Sports 21:474–481

    CAS  PubMed  Google Scholar 

  32. Gastmann UA, Lehmann MJ (1998) Overtraining and the BCAA hypothesis. Med Sci Sports Exerc 30:1173–1178

    CAS  PubMed  Google Scholar 

  33. Blomstrand E, Perrett D, Parry-Billings M et al (1989) Effect of sustained exercise on plasma amino acid concentrations and on 5-hydroxytryptamine metabolism in six different brain regions in the rat. Acta Physiol Scand 136:473–482

    CAS  PubMed  Google Scholar 

  34. Davis JM, Bailey SP (1997) Possible mechanisms of central nervous system fatigue during exercise. Med Sci Sports Exerc 29:45–57

    CAS  PubMed  Google Scholar 

  35. Dey S, Singh RH, Dey PK (1992) Exercise training: significance of regional alterations in serotonin metabolism of rat brain in relation to antidepressant effect of exercise. Physiol Behav 52:1095–1099

    CAS  PubMed  Google Scholar 

  36. Parnavelas JG, Papadopoulos GC (1989) The monoaminergic innervation of the cerebral cortex is not diffuse and nonspecific. Trends Neurosci 12:315–319

    CAS  PubMed  Google Scholar 

  37. Carneiro LS, Mota MP, Vieira-Coelho MA et al (2017) Monoamines and cortisol as potential mediators of the relationship between exercise and depressive symptoms. Eur Arch Psychiatry Clin Neurosci 267:117–121

    PubMed  Google Scholar 

  38. Tsai HC, Yeh TL, Hsieh MH et al (2009) Association between serotonin transporter availability and overall rating scores of quality of life in healthy volunteers. Prog Neuropsychopharmacol Biol Psychiatry 33:711–714

    CAS  PubMed  Google Scholar 

  39. Szeitz A, Bandiera SM (2017) Analysis and measurement of serotonin. Biomed Chromatog 32:e4135

    Google Scholar 

  40. Liu Z, Wu Y, Liu T et al (2017) Serotonin regulation in a rat model of exercise-induced chronic fatigue. Neuroscience 349:27–34

    CAS  PubMed  Google Scholar 

  41. Cordeiro LMS, Rabelo PCR, Moraes MM et al (2017) Physical exercise-induced fatigue: the role of serotonergic and dopaminergic systems. Braz J Med Biol Res 50:e6432

    CAS  PubMed  PubMed Central  Google Scholar 

  42. Salomon RM, Cowan RL (2013) Oscillatory serotonin function in depression. Synapse 67:801–820

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Żmudzka E, Sałaciak K, Sapa J et al (2018) Serotonin receptors in depression and anxiety: Insights from animal studies. Life Sci 210:106–124

    PubMed  Google Scholar 

Download references

Acknowledgements

The authors acknowledge Diagnósticos do Brasil laboratory for serotonin analysis.

Funding

This research was supported by the National Council for Scientific and Technological Development (CNPq; Grant numbers 308290/2015-1 to NS).

Author information

Authors and Affiliations

  1. Exercise Research Laboratory, School of Physical Education, Physical Therapy and Dance, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    Caroline Pietta-Dias

  2. Department of Sports, School of Physical Education, Centro Universitário da Serra Gaúcha, Caxias do Sul, Brazil

    Maqueli Dal Bello, Rogeane da Silva, Carol Vargas, Cristian Roncada & Carlos Leandro Tiggemann

  3. Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil

    Gustavo Dalto Barroso Machado

  4. National Institute of Science and Technology for Translational Medicine (INCT-TM), Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brasília, Brazil

    Nadja Schröder

  5. Physiology Department, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, Porto Alegre, RS, 90050-170, Brazil

    Nadja Schröder

Authors
  1. Caroline Pietta-Dias
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maqueli Dal Bello
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rogeane da Silva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Carol Vargas
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Gustavo Dalto Barroso Machado
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Cristian Roncada
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Carlos Leandro Tiggemann
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Nadja Schröder
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nadja Schröder.

Ethics declarations

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards and approved by the Ethics Committee of Centro Universitário da Serra Gaúcha (Círculo-FSG, #1.169.580), Rio Grande do Sul, Brazil.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pietta-Dias, C., Bello, M.D., da Silva, R. et al. Differential impact of endurance, strength, or combined training on quality of life and plasma serotonin in healthy older women. Aging Clin Exp Res 31, 1573–1581 (2019). https://doi.org/10.1007/s40520-019-01120-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40520-019-01120-x

Keywords

Search

Navigation