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Fracture healing in elderly patients: new challenges for antiosteoporotic drugs

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Abstract

Osteoporosis is a major public health concern, characterized by low bone mass and structural deterioration of bone tissue, leading to bone fragility and an increased susceptibility to fracture. Fracture repair progresses through different pathways, striking a balance between bone formation and bone remodeling mechanisms. Conventionally, fracture repair is divided into defined stages, each characterized by a specific set of cellular and molecular events. In postmenopausal women and elderly patients, bone healing rates are conditioned by cellular and molecular alterations to bone tissue that result in a progressive deterioration of fracture healing ability. In addition, in elderly patients, comorbidities and drugs therapies may also affect fracture healing. For this reason, pharmacological research is now focused on the possible use of antiosteoporotic drugs to promote bone healing in frail patients.

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Conflict of interest

Authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Orthopedic and Traumatology, University of Rome “Tor Vergata”, Policlinico Tor Vergata Foundation, Viale Oxford 81, 00133, Rome, Italy

    Umberto Tarantino, Luca Saturnino, Alessandro Scialdoni, Maurizio Feola, Federico Maria Liuni, Valerio Tempesta & Pietro Pistillo

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  1. Umberto Tarantino
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  2. Luca Saturnino
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  3. Alessandro Scialdoni
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  4. Maurizio Feola
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  5. Federico Maria Liuni
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  6. Valerio Tempesta
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  7. Pietro Pistillo
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Correspondence to Umberto Tarantino.

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Tarantino, U., Saturnino, L., Scialdoni, A. et al. Fracture healing in elderly patients: new challenges for antiosteoporotic drugs. Aging Clin Exp Res 25 (Suppl 1), 105–108 (2013). https://doi.org/10.1007/s40520-013-0096-8

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  • DOI: https://doi.org/10.1007/s40520-013-0096-8

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