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High serum ferritin levels are associated with a reduced periodontium in women with anorexia nervosa

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Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity Aims and scope Submit manuscript

Abstract

Purpose

Impaired oral health is a well-known complication in individuals with eating disorders, although this is difficult to identify by mental health professionals. The aim of this study was to evaluate the relationship between routine blood parameters and two oral health outcomes (dental erosion, reduced periodontium) in women with eating disorders.

Methods

A face-to-face interview and a clinical oral examination were carried out in a cohort of 70 women from an addiction and psychiatry hospital unit. Biochemical and hematological parameters were collected in medical records at admission. Biological factors associated with a generalized reduced periodontium (≥ 30% of sites with clinical attachment loss ≥ 3 mm) and dental erosion [a basic erosive wear examination (BEWE) score ≥ 3] were determined by logistic regression models.

Results

Forty-five women with either anorexia nervosa (n = 27) or bulimia nervosa (n = 18) were included in the study. None of the women had active periodontitis or other inflammatory comorbidity. Women with ≥ 30% of sites with clinical attachment loss ≥ 3 mm and those with a BEWE score ≥ 3 were older than women that did not exhibit a generalized reduced periodontium or dental erosion (37.1 ± 10.4 versus 28.8 ± 7.4, p < 0.01 and 35.2 ± 9.7 versus 28.1 ± 7.8, p = 0.01), respectively. After adjustments for age and duration of eating disorder, high serum ferritin levels were associated with a generalized reduced periodontium [OR (95%CI) = 1.04 (1.01; 1.07)]. No association was found between biological factors and dental erosion.

Conclusion

Serum ferritin levels together with age may be helpful to mental health professionals in screening patients with eating disorders for adequate referral to a dentist.

Level III

Evidence obtained from a case–control analytic study.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors would like to thank Dr. Katia Jédéon, Dr. Anna Karimova and the nurses of the Psychiatric and Addiction Department of Paul Brousse Hospital for their help in conducting the oral examinations and medical data collection. The authors are grateful to participants of the PERIOED study, especially all the in- and outpatients and volunteers.

Funding

The authors received no financial support for the research, authorship, and/or publication of this article.

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Authors and Affiliations

  1. Department of Periodontology, U.F.R. of Odontology, Faculty of Odontology, Université de Paris, 75006, Paris, France

    Adrien Boillot, Alice Pallier, Philippe Bouchard & Hélène Rangé

  2. Department of Periodontology, Service of Odontology, AP-HP, Rothschild Hospital, 75012, Paris, France

    Adrien Boillot, Alice Pallier, Pierre Colon, Philippe Bouchard & Hélène Rangé

  3. Centre de recherche en Epidémiologie et Santé des Populations, CESP, INSERM U1178, Université de Paris, 75006, Paris, France

    Damien Ringuenet

  4. Service of Psychiatry, Eating Disorder Unit, AP-HP, GH Paris-Sud, Paul Brousse Hospital, 94800, Villejuif, France

    Damien Ringuenet

  5. Orofacial Sciences Department, School of Dentistry, University of California, San Francisco (UCSF), San Francisco, CA, USA

    Yvonne Kapila

  6. Department of Restorative Dentistry, U.F.R. of Odontology, Université de Paris, 75006, Paris, France

    Pierre Colon

  7. Université Claude Bernard Lyon 1, Multimatériaux et Interfaces, LMI, UMR CNRS 5615, 69603, Villeurbanne, France

    Pierre Colon

  8. Laboratory Orofacial Pathologies, Imaging and Biotherapies, EA 2496, Université de Paris, 92120, Montrouge, France

    Philippe Bouchard & Hélène Rangé

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  1. Adrien Boillot
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Contributions

Conceptualization: HR, PB, PC; methodology: DR, HR; formal analysis and investigation: AB, AP; writing original draft preparation: AB, HR; writing review and editing: YK, PB; supervision: PC, PB, HR.

Corresponding author

Correspondence to Hélène Rangé.

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On behalf of all authors, the corresponding author states that there is no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee of Paris Ile de France (Comité de Protection des Personnes n ° 13588) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Boillot, A., Ringuenet, D., Kapila, Y. et al. High serum ferritin levels are associated with a reduced periodontium in women with anorexia nervosa. Eat Weight Disord 25, 1763–1770 (2020). https://doi.org/10.1007/s40519-019-00832-3

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  • DOI: https://doi.org/10.1007/s40519-019-00832-3

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