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Ethnopharmacology, Phytochemistry, and Pharmacology of Ashtanga Ghrita: an Ayurvedic Polyherbal Formulation for Neurological Disorders

  • Natural Products: From Chemistry to Pharmacology (Z-Y Su, Section Editor)
  • Published:
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Abstract 

Purpose of Review

Ayurveda is an ancient Indian medical system with unique approaches for the treatment of various brain disorders. Ashtanga Ghrita, a cow Ghrita-based polyherbal classical formulation, has been well defined in ancient Ayurvedic texts Ashtanga Hridya to enhance speech, intellect, and memory. The formulation contains eight potent neuroprotective herbs along with clarified cow butter and milk. The review is aimed to come up with comprehensive scientific evidence regarding the plant ingredients of Ashtanga Ghrita so that it can be used for further clinical studies as well as to treat a variety of neurological diseases.

Recent Findings

The plant ingredients have been practiced since ancient times for various disorders in India as well as worldwide. The plants contain various phytochemicals including terpenes, steroids, glycosides, flavonoids, alkaloids, amino acids, fatty acids, aryl esters, and carbohydrates. The collected pharmacological evidence suggests that all the plant ingredients have neuroprotective, anxiolytic, antidepressant, antioxidant, immunomodulatory, sedative, antiproliferative, and anticonvulsant activity.

Summary

Based on the collected evidence, Ashtanga Ghrita may prove to be an effective neuroprotective drug and might be useful in various neurological disorders. Further, well-designed multicentric clinical trials are required to elucidate and comprehend the therapeutic potential of the formulation.

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Authors and Affiliations

  1. Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, Varanasi, 221005, India

    Jyoti Singh, Anupriya Singh, Vineet Sharma, Rohit Sharma & Dev Nath Singh Gautam

  2. Department of Medicinal Chemistry, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, Varanasi, 221005, India

    Tryambak Deo Singh & Meenakshi Singh

  3. University School of Pharmaceutical Sciences, Rayat Bhara University, Mohali-140103, Punjab, India

    Ruchika Garg

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  1. Jyoti Singh
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  8. Dev Nath Singh Gautam
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Conceptualization and design, Jyoti Singh, Anupriya Singh, and Vineet Sharma; manuscript revision, Meenakshi Singh and Ruchika Garg; editing and supervision, Rohit Sharma, Tryambak Deo Singh, and Dev Nath Singh Gautam. All authors approved submission of the final manuscript.

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Correspondence to Dev Nath Singh Gautam.

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Singh, J., Singh, A., Sharma, V. et al. Ethnopharmacology, Phytochemistry, and Pharmacology of Ashtanga Ghrita: an Ayurvedic Polyherbal Formulation for Neurological Disorders. Curr Pharmacol Rep 8, 376–407 (2022). https://doi.org/10.1007/s40495-022-00300-0

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