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Emerging Role of Garcinol in Targeting Cancer Stem Cells of Non-small Cell Lung Cancer

  • Natural Products: From Chemistry to Pharmacology (C Ho, Section Editor)
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Abstract

Garcinol is a polyisoprenylated benzophenone analogue primarily isolated from the dried rind of Garcinia indica, a tropical fruit widely grown in Southeast Asia and Central Africa. Recent findings have well documented that garcinol is a potential dietary phytochemical candidate in the prevention and treatment of cancer and oxidative-related illness. Herein, a brief structure-activity relationship (SAR) is summarized in this review to disclose the connection between the chemical structure of garcinol and its biological activity. Non-small cell lung cancer (NSCLC) is a predominant type of lung cancer, exhibiting an extremely high mortality rate as a result of failing to clean up cancer stem cells (CSCs). Interestingly, garcinol was reported to be able to target and suppress CSCs, and both in vitro and in vivo evidences have revealed the outstanding anti-NSCLC potential of garcinol. The mechanism may involve cellular senescence and apoptosis induction, as well as cell cycle arrest. This paper will review the current progress of garcinol against various tumors in vitro and in vivo, particularly the effects on NSCLC, and summarize the critical structural features of garcinol as a potent anticancer candidate. Also, we will discuss potential future challenges in research and development of garcinol.

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Funding

This study received support from the National Natural Science Foundation of China (grant numbers 31571832 and 81803548), Key Program of Tianjin Municipal Health Bureau (grant number 2013-GG-05), and Tianjin Innovative Research Team Grant (grant number TD-13-5087), and Open Grant from Tianjin Key Laboratory of Food Biotechnology (TJCU-KLFB-18201).

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Authors and Affiliations

  1. Tianjin Key Laboratory of Food and Biotechnology, Food Science Division, School of Biotechnology and Food Science, Tianjin University of Commerce, No. 409 Guangrong Rd., Beichen District, Tianjin, 300134, People’s Republic of China

    Liang Wang, Meiyan Wang & Hui Zhao

  2. Department of Biotherapy, Third Central Hospital of Tianjin Medical University, Tianjin, 300170, China

    Hongxing Guo

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  1. Liang Wang
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  2. Meiyan Wang
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  3. Hongxing Guo
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  4. Hui Zhao
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Correspondence to Meiyan Wang.

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Wang, L., Wang, M., Guo, H. et al. Emerging Role of Garcinol in Targeting Cancer Stem Cells of Non-small Cell Lung Cancer. Curr Pharmacol Rep 5, 14–19 (2019). https://doi.org/10.1007/s40495-019-00169-6

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  • DOI: https://doi.org/10.1007/s40495-019-00169-6

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