Abstract
Purpose
Skeletal muscle ultrasound is a valuable tool for assessing muscle wasting in ICU. Previous studies on skeletal muscle ultrasound in ICU have been performed on lower limb muscles. The current study is formulated to assess the feasibility and reliability of anterior temporalis (AT) muscle ultrasound for measuring muscle wasting in ICU.
Methods
In this prospective cohort study in 48 critically ill patients with sepsis, muscle layer thicknesses (MLTs) and mean grayscale (GS) values of anterior temporalis muscles and quadriceps femoris (Q) were measured at baseline and serially till 7 days. Correlation was made between baseline and change in MLT and GS values of AT and Q muscle and these parameters were compared between ICU survivors and non survivors.
Results
Baseline anterior temporalis MLTs or their longitudinal changes over 7 days did not correlate significantly with the corresponding parameters of quadriceps femoris muscles. The baseline GS values of two muscle groups correlated weakly at baseline, but the change in GS over 7 days showed no correlation. The baseline MLTs of both muscle groups and their longitudinal change over 7 days did not correlate with ICU length of stay. The change in MLT of AT over 7 days was significantly greater in ICU non-survivors compared to survivors.
Conclusion
Measurement of ultrasonographic muscle layer thickness and grayscale parameters of anterior temporalis muscle did not show good correlation with that of quadriceps muscle.
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All authors contributed to the study conception and design. Material preparation was performed by Anirban Bhattacharjee (AB), Rahul Kumar Anand (RKA), Rajeshwari Subramaniam (RS), Dalim Kumar Baidya (DKB), Vimi Rewari (VR), and Manisha Jana (MJ). Data collection was done by AB, RA and MJ. Data analysis was done by AB, DKB, Bikash Ranjan Ray (BKR) and Puneet Khanna (PK). The first draft of the manuscript was written by AB, RA and DKB and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Ethical clearance was obtained from the institute ethics board, and the trial was pre-registered with the national clinical trial registry.
Trial registration number: CTRI/2018/09/015827 [Registered on: 25/09/2018].
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Anand, R.K., Bhattacharjee, A., Baidya, D.K. et al. Feasibility of anterior temporalis muscle ultrasound for assessing muscle wasting in ICU: a prospective cohort study. J Ultrasound 26, 653–661 (2023). https://doi.org/10.1007/s40477-022-00703-1
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DOI: https://doi.org/10.1007/s40477-022-00703-1