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Relationships Between Resistance and Virulence in Burkholderia pseudomallei

  • Melioidosis and Tropical Bacteriology (A Torres, Section Editor)
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Abstract

Purpose of Review

Aroused by the capacity of bacteria to develop antimicrobial resistance which allows them to persist in patient under antibiotic treatment, and their adaptation to host defenses by modifying their virulence, we review the relationship between antibiotic resistance and virulence in Burkholderia pseudomallei.

Recent Finding

Few studies focused on both antibiotic resistance and virulence. The relationship between these two mechanisms is very complex. Main resistance mechanisms such as efflux, biofilm, morphological changes or persistence are linked to virulence but results are still controversial. Recent clinical reports seem to indicate that reductive evolution is involved for balancing antibiotic resistance and virulence in chronic melioidosis cases.

Summary

The relation of virulence and resistance should be more considered to better understand the resistance, persistence, and pathogenicity of B. pseudomallei. Focusing on these two mechanisms, it will be possible to improve therapeutic options against this important emerging disease and avoid therapy failures or relapses for B. pseudomallei.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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  1. Unité de Bactériologie UMR_MD1, Institut de Recherche Biomédicale des Armées (IRBA), 1 place du Général Valérie André BP73, 91223, Brétigny-sur-Orge, France

    Marine Schnetterle, Lionel Koch, Olivier Gorgé, Eric Valade, Fabrice Biot & Fabienne Neulat-Ripoll

  2. Ecole du Val de Grâce, Paris, France

    Eric Valade

  3. TMCD2 UMR_MD1, Aix Marseille Université, Marseille, France

    Jean-Michel Bolla

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  1. Marine Schnetterle
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  2. Lionel Koch
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Correspondence to Fabienne Neulat-Ripoll.

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Marine Schnetterle is supported by DGA/MRIS France.

Lionel Koch, Olivier Gorgé, Eric Valade, Jean-Michel Bolla, Fabrice Biot, and Fabienne Neulat-Ripoll each declare no potential conflicts of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Melioidosis and Tropical Bacteriology

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Schnetterle, M., Koch, L., Gorgé, O. et al. Relationships Between Resistance and Virulence in Burkholderia pseudomallei . Curr Trop Med Rep 4, 127–135 (2017). https://doi.org/10.1007/s40475-017-0119-1

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