“DISTRESS | meaning in the Cambridge English Dictionary.” [Online]. Available: https://dictionary.cambridge.org/dictionary/english/distress. [Accessed: 10-Feb-2020].
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Schulz R, Beach SR. Caregiving as a Risk Factor for Mortality The Caregiver Health Effects Study. JAMA. 1999;282(23):2215–9.
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van der Valk ES, Savas M, van Rossum EFC. Stress and Obesity: Are There More Susceptible Individuals? Curr Obes Rep. 2018;7(2):193–203.
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Iob E, Steptoe A. Cardiovascular Disease and Hair Cortisol: a Novel Biomarker of Chronic Stress. Curr Cardiol Rep. 2019;21(10):116 Current Medicine Group LLC 1.
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• Cole SW. The Conserved Transcriptional Response to Adversity. Curr Opin Behav Sci. 2019;28:31–7 Elsevier Ltd. This review provides an overview of recent studies showing the impact of chronic stress on the gene expression profile of circulating immune cells, myeloid cells in particular. Beta-adrenergic signaling to cells developing in the bone marrow mediates this alteration.
Fredrickson BL, Grewen KM, Coffey KA, Algoe SB, Firestine AM, Arevalo JMG, et al. A functional genomic perspective on human well-being. Proc Natl Acad Sci U S A. 2013;110(33):13684–9.
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•• Tawakol A, et al. Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study. Lancet. 2017;389(10071):834–45 This study demonstrates a direct association in humans between stress-related amygdalar activity, bone marrow response, and arterial inflammation, thereby providing a direct link between perceived stress, monocyte differentiation, and cardiovascular disease.
Weber MD, Godbout JP, Sheridan JF. Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal. Neuropsychopharmacology. 2017;42(1) Nature Publishing Group:46–61.
Finnell JE, Wood SK. Putative inflammatory sensitive mechanisms underlying risk or resilience to social stress. Front Behav Neurosci. 2018;12:240. Frontiers Media S.A.
Ménard C, Pfau ML, Hodes GE, Russo SJ. Immune and neuroendocrine mechanisms of stress vulnerability and resilience. Neuropsychopharmacology. 2017;42(1):62–80.
• Nasca C, Menard C, Hodes G, Bigio B, Pena C, Lorsch Z, et al. Multidimensional predictors of susceptibility and resilience to social defeat stress. Biol Psychiatry. 2019;86(6):483–91 Using a mouse model the authors identify different predictors of stress susceptibility and resilience, including the in vitro inflammatory response of peripheral blood leukocytes to lipopolysaccharide.
Tsyglakova M, McDaniel D, Hodes GE. Immune mechanisms of stress susceptibility and resilience: Lessons from animal models. Front Neuroendocrinol. 2019;54:100771. Academic Press Inc.
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James Cy JE, Leader G. Parenting stress, salivary biomarkers, and ambulatory blood pressure: a comparison between mothers and fathers of children with autism spectrum disorders. J Autism Dev Disord. 2015;45(4):1084–95.
Lovell B, Moss M, Wetherell M. The psychosocial, endocrine and immune consequences of caring for a child with autism or ADHD. Psychoneuroendocrinology. 2012;37(4):534–42.
Sherwood PR, Price TJ, Weimer J, Ren D, Donovan HS, Given CW, et al. Neuro-oncology family caregivers are at risk for systemic inflammation. J Neuro-Oncol. 2016;128(1):109–18.
Picard M, Prather AA, Puterman E, Cuillerier A, Coccia M, Aschbacher K, et al. A mitochondrial health index sensitive to mood and caregiving stress. Biol Psychiatry. Jul. 2018;84(1):9–17.
Chen Y, Zhou Z, Min W. Mitochondria, oxidative stress and innate immunity. Front Physiol. 2018;9:1487, no. OCT. Frontiers Media S.A.
Romero-Martínez Á, Moya-Albiol L. Stress-induced endocrine and immune dysfunctions in caregivers of people with eating disorders. Int J Environ Res Public Health. 2017;14(12):1560.
Whittaker AC, Gallagher S. Caregiving alters immunity and stress hormones: a review of recent research. Curr Opin Behav Sci. 2019;28. Elsevier Ltd:93–7.
Vitlic A, Lord JM, Taylor AE, Arlt W, Bartlett DB, Rossi A, et al. Neutrophil function in young and old caregivers. Br J Health Psychol. 2016;21(1):173–89.
Hollins SL, Hodgson DM. Stress, microbiota, and immunity. Curr Opin Behav Sci. 2019;28. Elsevier Ltd:66–71.
Chen F, Stappenbeck TS. Microbiome control of innate reactivity. Curr Opin Immunol. 2019;56. Elsevier Ltd:107–13.
• Valles-Colomer M, et al. The neuroactive potential of the human gut microbiota in quality of life and depression. Nat Microbiol. 2019;4(4):623–32 First large-scale, replicated, population-based study that confirmed associations between gut microbiota and mental health.
Malan-Muller S, Valles-Colomer M, Raes J, Lowry CA, Seedat S, Hemmings SMJ. The gut microbiome and mental health: Implications for anxiety- and trauma-related disorders. OMICS J Integr Biol. 2018;22(2) Mary Ann Liebert Inc.:90–107.
Li Q, Han Y, Dy ABC, Hagerman RJ. The gut microbiota and autism spectrum disorders. Front Cell Neurosci. 2017;11. Frontiers Media S.A.
Dinan TG, Cryan JF. Brain-Gut-Microbiota Axis and Mental Health. Psychosom Med. 2017;79(8) Lippincott Williams and Wilkins:920–6.
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• Bruce-Keller AJ, Salbaum JM, Berthoud HR. Harnessing Gut Microbes for Mental Health: Getting From Here to There. Biol Psychiatry. 2018;83(3):214–23 Elsevier USA. Provides an overview of the potential possibilities and current limitations of gut microbiota manipulation to influence mental health.
Madison A, Kiecolt-Glaser JK. Stress, depression, diet, and the gut microbiota: human–bacteria interactions at the core of psychoneuroimmunology and nutrition. Curr Opin Behav Sci. 2019;28. Elsevier Ltd:105–10.
Bastiaanssen TFS, Cowan CSM, Claesson MJ, Dinan TG, Cryan JF. Making sense of ⋯ the microbiome in psychiatry. Int J Neuropsychopharmacol. 2018;22(1):37–52.
Cryan JF, O’Riordan KJ, Sandhu K, Peterson V, Dinan TG. The gut microbiome in neurological disorders. Lancet Neurol. 2020;19(2) Lancet Publishing Group:179–94.
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Clarke G, Grenham S, Scully P, Fitzgerald P, Moloney RD, Shanahan F, et al. The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry. 2013;18(6):666–73.
Möhle L, Mattei D, Heimesaat MM, Bereswill S, Fischer A, Alutis M, et al. Ly6Chi monocytes provide a link between antibiotic-induced changes in gut microbiota and adult hippocampal neurogenesis. Cell Rep. 2016;15(9):1945–56.
O’Mahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res. 2015;277. Elsevier:32–48.
Ogbonnaya ES, Clarke G, Shanahan F, Dinan TG, Cryan JF, O’Leary OF. Adult Hippocampal Neurogenesis Is Regulated by the Microbiome. Biol Psychiatry. 2015;78(4) Elsevier USA:e7–9.
Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell. 2015;161(2):264–76.
Messaoudi M, Lalonde R, Violle N, Javelot H, Desor D, Nejdi A, et al. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr. 2011;105(5):755–64.
El Aidy M, Kunze S, Bienenstock W, Kleerebezem J. The microbiota and the gut-brain axis: insights from the temporal and spatial mucosal alterations during colonisation of the germfree mouse intestine. Benefic Microbes. 2012;1(3, 4):251–9.
Kelly JR, Borre Y, O' Brien C, Patterson E, el Aidy S, Deane J, et al. Transferring the blues: depression-associated gut microbiota induces neurobehavioural changes in the rat. J Psychiatr Res. 2016;82:109–18.
Cheung SG, Goldenthal AR, Uhlemann AC, Mann JJ, Miller JM, Sublette ME. Systematic review of gut microbiota and major depression. Front Psychiatry. 2019;10:34, no. FEB. Frontiers Media S.A.
Lafuse WP, Gearinger R, Fisher S, Nealer C, Mackos AR, Bailey MT. Exposure to a social stressor induces translocation of commensal lactobacilli to the spleen and priming of the innate immune system. J Immunol. 2017;198(6):2383–93.
Bailey MT, “Psychological stress, immunity, and the effects on indigenous microflora.,” Adv Exp Med Biol, pp. 225–46, 2016.
Dominguez-Andres J, Netea MG. Long-term reprogramming of the innate immune system. J Leukoc Biol. 2019;105(2) John Wiley and Sons Inc.:329–38.
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Talbott SM, Talbott JA, Stephens BJ, Oddou MP. Effect of Coordinated Probiotic/Prebiotic/Phytobiotic Supplementation on Microbiome Balance and Psychological Mood State in Healthy Stressed Adults. Funct Foods Heal Dis. 2019;9(4):265.