Mularski RA, White-Chu F, Overbay D, Miller L, Asch SM, Ganzini L. Measuring pain as the 5th vital sign does not improve quality of pain management. J Gen Intern Med. 2006;21(6):607–12. doi:10.1111/j.1525-1497.2006.00415.x.
Lembke A. Why doctors prescribe opioids to known opioid abusers. N Engl J Med. 2012;367(17):1580–1. doi:10.1056/NEJMp1208498. Excellent breif exploration of the role doctors have played in contributing to the prescription drug epidemic.
Centers for Medicare & Medicaid Services. National health expenditures by source of funds and type of expenditures: Calendar years 2005–2011 (table 4). 2011.
Eriksen J, Sjøgren P, Bruera E, Ekholm O, Rasmussen NK. Critical issues on opioids in chronic non-cancer pain: an epidemiological study. Pain. 2006;125(1):172–9.
Kalso E, Edwards JE, Moore RA, McQuay HJ. Opioids in chronic non-cancer pain: systematic review of efficacy and safety. Pain. 2004;112(3):372–80.
Manchikanti L, Atluri S, Hansen H. Opioids in chronic noncancer pain: have we reached a boiling point yet? Pain Phys. 2014;17:E1–10.
Caudill-Slosberg MA, Schwartz LM, Woloshin S. Office visits and analgesic prescriptions for musculoskeletal pain in US: 1980 vs. 2000. Pain. 2004;109(3):514–9.
Chapman CR, Lipschitz DL, Angst MS, Chou R, Denisco RC, Donaldson GW, et al. Opioid pharmacotherapy for chronic non-cancer pain in the United States: a research guideline for developing an evidence-base. J Pain. 2010;11(9):807–29.
Sehgal N, Manchikanti L, Smith HS. Prescription opioid abuse in chronic pain: a review of opioid abuse predictors and strategies to curb opioid abuse. Pain Phys. 2012;15(3 Suppl):ES67–92.
Governale L. Outpatient prescription opioid utilization in the US, years 2000–2009. Food and Drug Administration, Division of Epidemiology; 2010.
Manchikanti L. National drug control policy and prescription drug abuse: facts and fallacies. Pain Phys. 2007;10(3):399.
Deandrea S, Montanari M, Moja L, Apolone G. Prevalence of undertreatment in cancer pain. A review of published literature. Ann Oncol. 2008;19(12):1985–91.
Marks RM, Sachar EJ. Undertreatment of medical inpatients with narcotic analgesics. Ann Intern Med. 1973;78(2):173–81.
Webster LR, Fine PG. Approaches to improve pain relief while minimizing opioid abuse liability. J Pain. 2010;11(7):602–11.
Stanos SP, Fishbain DA, Fishman SM. Pain management with opioid analgesics: balancing risk & benefit. Am J Phys Med Rehabil. 2009;88(3):S69–99.
Joranson D, Ryan K, Gilson A, Dahl J. Trends in medical use and abuse of opioid analgesics. JAMA. 2000;283(13):1710.
Portenoy RK, Foley KM. Chronic use of opioid analgesics in non-malignant pain: report of 38 cases. Pain. 1986;25(2):171–86.
Weissman DE, Haddox JD. Opioid pseudoaddiction--an iatrogenic syndrome. Pain. 1989;36(3):363–6.
Wright ER, Kooreman HE, Greene MS, Chambers RA, Banerjee A, Wilson J. The iatrogenic epidemic of prescription drug abuse: county-level determinants of opioid availability and abuse. Drug Alcohol Depend. 2014;138:209–15. This paper is one of the first state-wide epidemological association studies (Indiana) that demonstrates a connection between geograpical access to general health care and pharmacies and risk of opioid addiction.
Compton WM, Volkow ND. Major increases in opioid analgesic abuse in the United States: concerns and strategies. Drug Alcohol Depend. 2006;81(2):103–7.
Substance Abuse and Mental Health Services Administration. Drug abuse warning network, 2011: national estimates of Drug-Related Emergency Department Visits. In: HHS Publication No. (SMA) 13–4760, DAWN Series D-39. Substance Abuse and Mental Health Services Administration, Rockville, MD. 2011. http://www.samhsa.gov/data/2k13/DAWN2k11ED/DAWN2k11ED.htm#tab21.
Centers for Disease Control and Prevention, National Center for Health Statistics. Number of deaths from poisoning, drug poisoning, and drug poisoning involving opioid analgesics — United States, 1999–2010. Morbidity and Mortality Weekly Report, March 29, 2013. 2013. A definitive epidemiological snapshot of the growth and impact of the iatrogenic opioid epidemic in the United States as a major public health crisis.
Yokell MA, Delgado MK, Zaller ND, Wang NE, McGowan SK, Green TC. Presentation of prescription and nonprescription opioid overdoses to US emergency departments. JAMA Intern Med. 2014;174(12):2034–7. doi:10.1001/jamainternmed.2014.5413. This paper provides an important view on the scope of human and economic costs of prescription opioid overdoses, just interms of emergency and critical care services that could be prevented with better access to addiction treatment.
Executive Office of the President Office of National Drug Control Policy. Examining the Federal Government’s Response to the Prescription Drug Abuse Crisis: Written Statement of R. Gil Kerlikowske, June 14, 2013. 2013. http://democrats.energycommerce.house.gov/sites/default/files/documents/Testimony-Kerlikowske-Health-Rx-Drug-Abuse-2013-6-14.pdf
Wachholtz AB, Gonzalez G, Boyer EW, Naqvi ZN, Rosenbaum CD, Ziedonis DM. Intersection of chronic pain treatment and opioid analgesic misuse: causes, treatments, and policy strategies. 2011.
Substance Abuse and Mental Health Services Administration. National Survey on Drug Use and Health (NSDUH). Substance Abuse and Mental Health Services Administration, Rockville, MD. 2012. http://www.samhsa.gov/data/NSDUH.aspx.
Hackman DT, Greene MS, Fernandes TJ, Brown AM, Wright ER, Chambers RA. Prescription drug monitoring program inquiry in psychiatric assessment: detection of high rates of opioid prescribing to a dual diagnosis population. J Clin Psychiatry. 2014;75(7):750–6. doi:10.4088/JCP.14m09020. First use of a prescription drug monitoring program database to document the high penetrance of opoid prescribing for pain, and in appropriate combinations of opoiods with benzodiazepines to a population of mentally ill patients with addictions.
Manchikanti L, Vallejo R. Effectiveness of long-term opioid therapy for chronic non-cancer pain. Pain Phys. 2011;14:E133–56.
Haddox J, Joranson D, Angarola R, Brady A, Carr D, Blonsky E, et al. The use of opioids for the treatment of chronic pain. Clin J Pain. 1997;13(1):6–8.
Ballantyne JC, Shin NS. Efficacy of opioids for chronic pain: a review of the evidence. Clin J Pain. 2008;24(6):469–78.
Noble M, Tregear S, Treadwell J, Schoelles K. Long-term opioid therapy for chronic noncancer pain: a systematic review and meta-analysis of efficacy and safety. J Pain Symptom Manag. 2008;35(2):214–28.
Chou R, Fanciullo GJ, Fine PG, Adler JA, Ballantyne JC, Davies P, et al. Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J Pain. 2009;10(2):113–30. e22.
Franklin GM. Opioids for chronic noncancer pain: a position paper of the American Academy of Neurology. Neurology. 2014;83(14):1277–84. doi:10.1212/WNL.0000000000000839. First major postion statement by a neuroscienece-focused clinical specialty declaring that chronic non-terminal pain management with chronic opioids is not supported by the evidenece base as having aceptable risk-benefit ratio for most patients.
Sismondo S. Pharmaceutical company funding and its consequences: a qualitative systematic review. Contemp Clin Trials. 2008;29(2):109–13.
Elander J, Lusher J, Bevan D, Telfer P. Pain management and symptoms of substance dependence among patients with sickle cell disease. Soc Sci Med. 2003;57(9):1683–96.
Elander J, Lusher J, Bevan D, Telfer P, Burton B. Understanding the causes of problematic pain management in sickle cell disease: evidence that pseudoaddiction plays a more important role than genuine analgesic dependence. J Pain Symptom Manag. 2004;27(2):156–69. doi:10.1016/j.jpainsymman.2003.12.001.
Elander J, Marczewska M, Amos R, Thomas A, Tangayi S. Factors affecting hospital staff judgments about sickle cell disease pain. J Behav Med. 2006;29(2):203–14.
Fishbain D. Medico-legal rounds: medico-legal issues and breaches of “standards of medical care” in opioid tapering for alleged opioid addiction. Pain Med. 2002;3(2):135–42. discussion 43–6.
Gajraj N, Hervias-Sanz M. Opiate abuse or undertreatment? [Letter]. 1998.
Lusher J, Elander J, Bevan D, Telfer P, Burton B. Analgesic addiction and pseudoaddiction in painful chronic illness. Clin J Pain. 2006;22(3):316–24.
Passik SD, Kirsh KL. An opioid screening instrument: long-term evaluation of the utility of the pain medication questionnaire by Holmes et al. Pain Pract. 2006;6(2):69–71. doi:10.1111/j.1533-2500.2006.00065.x.
Passik SD, Kirsh KL, Webster L. Pseudoaddiction revisited: a commentary on clinical and historical considerations. Pain Manag. 2011;1(3):239–48.
Passik SD, Squire P. Current risk assessment and management paradigms: snapshots in the life of the pain specialist. Pain Med. 2009;10(S2):S101–14.
Porter-Williamson K, Heffernan E, von Gunten C. Pseudoaddiction. J Palliat Med. 2003;6(6):937–9.
Proctor SL, Estroff TW, Empting LD, Shearer-Williams S, Hoffmann NG. Prevalence of substance use and psychiatric disorders in a highly select chronic pain population. J Addict Med. 2013;7(1):17–24.
Savage S, Covington E, Heit H, Hunt J, Joranson D, Schnoll S. Definitions related to the use of opioids for the treatment of pain: a consensus document from the American Academy of Pain Medicine, the American Pain Society, and the American Society of Addiction Medicine. 2001.
Chabal C, Jacobson L, Mariano AJ, Chaney E. Opiate abuse or undertreatment? Clin J Pain. 1998;14(1):90–1.
Dowell D, Kunins HV, Farley TA. Opioid analgesics—Risky drugs, not risky patients opioid analgesics. JAMA. 2013;309(21):2219–20.
Spence D. Pain revisited: evidence for opioids. BMJ. 2010;340.
Vijayaraghavan M, Penko J, Bangsberg DR, Miaskowski C, Kushel MB. Opioid analgesic misuse in a community-based cohort of HIV-infected indigent adults. JAMA Int Med. 2013;173(3):235–7.
Bell K, Salmon A. Pain, physical dependence and pseudoaddiction: redefining addiction for ‘nice’people? Int J Drug Policy. 2009;20(2):170–8.
Keane H, Moore D, Fraser S. Addiction and dependence: making realities in the DSM. Addiction. 2011;106(5):875–7.
Gourlay DL, Heit HA, Almahrezi A. Universal precautions in pain medicine: a rational approach to the treatment of chronic pain. Pain Med. 2005;6(2):107–12.
Boscarino JA, Rukstalis MR, Hoffman SN, Han JJ, Erlich PM, Ross S, et al. Prevalence of prescription opioid-use disorder among chronic pain patients: comparison of the DSM-5 vs. DSM-4 diagnostic criteria. J Addict Dis. 2011;30(3):185–94.
Chabal C, Erjavec MK, Jacobson L, Mariano A, Chaney E. Prescription opiate abuse in chronic pain patients: clinical criteria, incidence, and predictors. Clin J Pain. 1997;13(2):150–5.
Højsted J, Sjøgren P. Addiction to opioids in chronic pain patients: a literature review. Eur J Pain. 2007;11(5):490–518.
Dhingra L, Masson C, Perlman DC, Seewald RM, Katz J, McKnight C, et al. Epidemiology of pain among outpatients in methadone maintenance treatment programs. Drug Alcohol Depend. 2013;128(1):161–5.
Sproule B, Brands B, Li S, Catz-Biro L. Changing patterns in opioid addiction: characterizing users of oxycodone and other opioids. Can Fam Physician. 2009;55(1):68–9. e5.
Rosenblum A, Joseph H, Fong C, Kipnis S, Cleland C, Portenoy RK. Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities. JAMA. 2003;289(18):2370–8.
Peles E, Schreiber S, Gordon J, Adelson M. Significantly higher methadone dose for methadone maintenance treatment (MMT) patients with chronic pain. Pain. 2005;113(3):340–6.
Wachholtz A, Foster S, Cheatle M. Psychophysiology of pain and opioid use: implications for managing pain in patients with an opioid use disorder. Drug Alcohol Depend. 2015;146:1–6. doi:10.1016/j.drugalcdep.2014.10.023. Excellent consideration of the evidence for how the pathophsyiologies of pain and addiction can co-occur and be interactive.
Flaherty SA. Pain measurement tools for clinical practice and research. AANA J. 1996;64(2):133–40.
Melzack R, Wall PD. The challenge of pain. 1988.
Arber A. Is pain what the patient says it is? Interpreting an account of pain. Int J Palliat Nurs. 2004;10(10):491–6.
Noble M, Treadwell JR, Tregear SJ, Coates VH, Wiffen PJ, Akafomo C, et al. Long-term opioid management for chronic noncancer pain. Cochrane Database Syst Rev. 2010;1:CD006605. doi:10.1002/14651858.CD006605.pub2.
Furlan AD, Sandoval JA, Mailis-Gagnon A, Tunks E. Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects. CMAJ. 2006;174(11):1589–94. doi:10.1503/cmaj.051528.
Crofford LJ. Adverse effects of chronic opioid therapy for chronic musculoskeletal pain. Nat Rev Rheumatol. 2010;6(4):191–7.
Sullivan MD, Howe CQ. Opioid therapy for chronic pain in the United States: promises and perils. Pain. 2013;154:S94–100. This review considers the wieght of the evidence revealing that chronic opiods for chronic pain has not worked out as hoped, and elaborates on ‘Adverse Selection’ where ironically, in U.S. healthcare patients who are most likely to be harmed by opioids tend to be the ones who are most agressively prescribed them.
Chaparro LE, Furlan AD, Deshpande A, Mailis-Gagnon A, Atlas S, Turk DC. Opioids compared to placebo or other treatments for chronic low back pain: an update of the cochrane review. Spine. 2014.
Chu LF, Clark DJ, Angst MS. Opioid tolerance and hyperalgesia in chronic pain patients after one month of oral morphine therapy: a preliminary prospective study. J Pain. 2006;7(1):43–8.
Chambers RA, Krystal JK, Self DW. A neurobiological basis for substance abuse comorbidity in schizophrenia. Biol Psychiatry. 2001;50:71–83.
Bair MJ, Robinson RL, Katon W, Kroenke K. Depression and pain comorbidity: a literature review. Arch Intern Med. 2003;163(20):2433.
Boscarino JA, Rukstalis M, Hoffman SN, Han JJ, Erlich PM, Gerhard GS, et al. Risk factors for drug dependence among out‐patients on opioid therapy in a large US health‐care system. Addiction. 2010;105(10):1776–82.
Fordyce WE, Lansky D, Calsyn DA, Shelton JL, Stolov WC, Rock DL. Pain measurement and pain behavior. Pain. 1984;18(1):53–69.
Chambers RA. Adult hippocampal neurogenesis in the pathogenesis of addiction and dual diagnosis disorders. Drug Alcohol Depend. 2013;130(1–3):1–12. doi:10.1016/j.drugalcdep.2012.12.005.
Kessler RC. The epidemiology of dual diagnosis. Biol Psychiatry. 2004;56:730–7.
Sullivan MD. Who gets high-dose opioid therapy for chronic non-cancer pain? Pain. 2010;151(3):567–8. doi:10.1016/j.pain.2010.08.036.