Dear Editor,

We would like to share ideas on “Humoral Immune Response to COVID-19 Vaccination in Hemodialysis Patients: A Retrospective, Observational Case-Control Pilot Study [1]”. Piscitani et al. noted that “This study supports the finding of hyporesponsiveness to mRNA vaccination among hemodialysis patients [1]”. The impact of COVID-19 vaccination on immunocompromised recipients is an interesting topic of research right now. In the event of hemodialysis, a reduced immune response is likely, which could influence the immune response to vaccination. Background immunological status could be a key factor influencing responsiveness [2]. An evaluation of the hemodialysis patient's immune function before vaccination could provide important information for determining the vaccine's effectiveness. Nevertheless, the impact of COVID-19 vaccine type should be considered. There is a difference in immunological response after immunization with different types of vaccines, according to a recent study [3].