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Vitamin D and Cardiometabolic Disorders

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Abstract

Recent clinical and experimental studies suggest that vitamin D status could play a significant role in the pathogenesis of cardiometabolic disorders as well as in their clinical severity. In particular, low vitamin D levels appear to increase the risk of major cardiovascular events in apparently healthy individuals and to worsen the prognosis quoad vitam and quoad valetudinem following a cardiovascular event. The relevance of these observations is amplified by the high prevalence of vitamin D deficiency and insufficiency that affect over one billion individuals at all ages worldwide. Randomized controlled trials are currently underway in U.S., Europe and Oceania to demonstrate a cause-effect relationship by assessing the effects of vitamin D supplementation on various cardiovascular outcomes. Aim of this review is to point out the more recent advances in knowledge about the relationship between vitamin D status and the incidence, prevalence and pathogenesis of more common cardiometabolic disorders.

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Authors and Affiliations

  1. Department of Clinical Medicine and Surgery, Excellence Center of Hypertension, “Federico II University” Medical School, via Sergio Pansini 5, 80131, Naples, Italy

    Domenico Rendina, Gianpaolo De Filippo, Riccardo Muscariello, Daniela De Palma, Anna Fiengo, Francesca De Pascale & Pasquale Strazzullo

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  1. Domenico Rendina
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  2. Gianpaolo De Filippo
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  3. Riccardo Muscariello
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  4. Daniela De Palma
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  6. Francesca De Pascale
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  7. Pasquale Strazzullo
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Correspondence to Pasquale Strazzullo.

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Rendina, D., De Filippo, G., Muscariello, R. et al. Vitamin D and Cardiometabolic Disorders. High Blood Press Cardiovasc Prev 21, 251–256 (2014). https://doi.org/10.1007/s40292-014-0060-5

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  • DOI: https://doi.org/10.1007/s40292-014-0060-5

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