Bischoff SC, Barbara G, Buurman W, Ockhuizen T, Schulzke JD, Serino M, et al. Intestinal permeability—a new target for disease prevention and therapy. BMC Gastroenterol. 2014;14:1–25.
Google Scholar
Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol. 2009;9:799–809.
CAS
PubMed
Google Scholar
van Wijck K, Lenaerts K, Grootjans J, Wijnands KAP, Poeze M, van Loon LJC, et al. Physiology and pathophysiology of splanchnic hypoperfusion and intestinal injury during exercise: strategies for evaluation and prevention. Am J Physiol Gastrointest Liver Physiol. 2012;303:G155–68.
PubMed
Google Scholar
van Wijck K, Pennings B, van Bijnen AA, Senden JMG, Buurman WA, Dejong CHC, et al. Dietary protein digestion and absorption are impaired during acute postexercise recovery in young men. Am J Physiol Regul Integr Comp Physiol. 2013;304:R356–61.
PubMed
Google Scholar
Van Houten JM, Wessells RJ, Lujan HL, DiCarlo SE. My gut feeling says rest: increased intestinal permeability contributes to chronic diseases in high-intensity exercisers. Med Hypotheses. 2015;85:882–6.
PubMed
Google Scholar
Costa RJS, Snipe RMJ, Kitic CM, Gibson PR. Systematic review : exercise-induced gastrointestinal syndrome—implications for health and intestinal disease. Aliment Pharmacol Ther. 2017;46:246–65.
CAS
PubMed
Google Scholar
Buchman AL, Killip D, Rognerud CL, Pownall H, Dennis K, Kay DJ. Short-term vitamin E supplementation before marathon running: a placebo-controlled trial. Nutrition. 1999;15:278–83.
CAS
PubMed
Google Scholar
Pugh JN, Sparks AS, Doran DA, Fleming SC, Langan-Evans C, Kirk B, et al. Four weeks of probiotic supplementation reduces GI symptoms during a marathon race. Eur J Appl Physiol. 2019;119:1491–501.
PubMed
PubMed Central
Google Scholar
Janssen Duijghuijsen LM, Mensink M, Lenaerts K, Fiedorowicz E, van Dartel DAM, Mes JJ, et al. The effect of endurance exercise on intestinal integrity in well-trained healthy men. Physiol Rep. 2016;4:e12994.
Google Scholar
Voth M, Duchene M, Auner B, Lustenberger T, Relja B, Marzi I. I-FABP is a novel marker for the detection of intestinal injury in severely injured trauma patients. World J Surg. 2017;41:3120–7.
CAS
PubMed
Google Scholar
Van Wijck K, Lenaerts K, Van Bijnen AA, Boonen B, Van Loon LJC, Dejong CHC, et al. Aggravation of exercise-induced intestinal injury by ibuprofen in athletes. Med Sci Sports Exerc. 2012;44:2257–62.
PubMed
Google Scholar
van Wijck K, Lenaerts K, van Loon LJC, Peters WHM, Buurman WA, Dejong CHC. Exercise-Induced splanchnic hypoperfusion results in gut dysfunction in healthy men. PLoS ONE. 2011;6:e22366.
PubMed
PubMed Central
Google Scholar
van Wijck K, van Eijk HMH, Buurman WA, Dejong CHC, Lenaerts K. Novel analytical approach to a multi-sugar whole gut permeability assay. J Chromatogr B Anal Technol Biomed Life Sci. 2011;879:2794–801.
Google Scholar
Van Nieuwenhoven MA, De Swart EAM, Van Eijk HM, Deutz NEP, Brouns F, Brummer RJM. Effects of pre- and post-absorptive factors on the lactulose/rhamnose gut permeability test. Clin Sci. 2000;98:349–53.
Google Scholar
Sequeira IR, Lentle RG, Kruger MC, Hurst RD. Standardising the lactulose mannitol test of gut permeability to minimise error and promote comparability. PLoS One. 2014;9.
Rao AS, Camilleri M, Eckert DJ, Busciglio I, Burton DD, Ryks M, et al. Urine sugars for in vivo gut permeability: validation and comparisons in irritable bowel syndrome-diarrhea and controls. Am J Physiol Gastrointest Liver Physiol. 2011;301:G919–28.
CAS
PubMed
PubMed Central
Google Scholar
Lee JY, Wasinger VC, Yau YY, Chuang E, Yajnik V, Leong RWL. Molecular pathophysiology of epithelial barrier dysfunction in inflammatory bowel diseases. Proteomes. 2018;6:1–17.
CAS
Google Scholar
Pals KL, Chang RT, Ryan AJ, Gisolfi CV. Effect of running intensity on intestinal permeability. J Appl Physiol. 1997;82:571–6.
CAS
PubMed
Google Scholar
Vargas N, Marino F. Heat stress, gastrointestinal permeability and interleukin-6 signaling—implications for exercise performance and fatigue. Temperature. 2016;3:240–51.
Google Scholar
Sheahen B, Fell J, Zadow E, Hartley T, Kitic CM. Intestinal damage following short duration exercise at the same relative intensity is similar in temperate and hot environments. Appl Physiol Nutr Metab. 2018;1–28.
Pires W, Veneroso CE, Wanner SP, Pacheco DAS, Vaz GC, Amorim FT, et al. Association between exercise-induced hyperthermia and intestinal permeability: a systematic review. Sport Med. 2017;47:1389–403.
Google Scholar
De Oliveira EP, Burini RC, Jeukendrup A. Gastrointestinal complaints during exercise: prevalence, etiology, and nutritional recommendations. Sport Med. 2014;44:79–85.
Google Scholar
Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (prisma-p) 2015: elaboration and explanation. BMJ. 2015;349:1–25.
Google Scholar
Higgins, Altman, Sterne. Chapter 8: Assessing risk of bias in included studies. Cochrane Handb Syst Rev Interv Version 510 (updated March 2011) Cochrane Collab 2011. www.cochrane-handbook.org. 2011.
Wan X, Wang W, Liu J, Tong T. Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol. 2014;14:135.
PubMed
PubMed Central
Google Scholar
Altman DG, Bland JM. Standard deviations and standard errors. BMJ. 2005;331:903.
PubMed
PubMed Central
Google Scholar
Higgins JPT, Thompson SG, Spiegelhalter DJ. A re-evaluation of random-effects meta-analysis. J R Stat Soc Ser A Stat Soc. 2009.
Marchbank T, Davison G, Oakes JR, Ghatei MA, Patterson M, Moyer MP, et al. The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes. Am J Physiol Gastrointest Liver Physiol. 2011;300:477–84.
Google Scholar
Hawley JA, Noakes TD. Peak power output predicts maximal oxygen uptake and performance time in trained cyclists. Eur J Appl Physiol. 1992;65:79–83.
CAS
Google Scholar
Wassertheil S, Cohen J. Statistical power analysis for the behavioral sciences. Biometrics. 1970.
Higgins J, Thompson S, Deeks J, Altman D. Statistical heterogeneity in systematic reviews of clinical trials: a critical appraisal of guidelines and practice. J Health Serv Res Policy. 2002;7:51–61.
PubMed
Google Scholar
IUPS Thermal Commission I. Glossary of terms for thermal physiology. Third Edition. Revised by The Commission for Thermal Physiology of the International Union of Physiological Sciences. Jpn J Physiol. 2001;51:245–80.
Karhu E, Forsgård RA, Alanko L, Alfthan H, Pussinen P, Hämäläinen E, et al. Exercise and gastrointestinal symptoms: running-induced changes in intestinal permeability and markers of gastrointestinal function in asymptomatic and symptomatic runners. Eur J Appl Physiol. 2017;117:2519–26.
PubMed
PubMed Central
Google Scholar
Kartaram S, Mensink M, Teunis M, Schoen E, Witte G, Janssen Duijghuijsen L, et al. Plasma citrulline concentration, a marker for intestinal functionality, reflects exercise intensity in healthy young men. Clin Nutr. 2019;38:2251–8.
CAS
PubMed
Google Scholar
Lis D, Stellingwerff T, Kitic CM, Ahuja KDK, Fell J. No effects of a short-term gluten-free diet on performance in nonceliac athletes. Med Sci Sports Exerc. 2015;47:2563–70.
CAS
PubMed
Google Scholar
March DS, Marchbank T, Playford RJ, Jones AW, Thatcher R, Davison G. Intestinal fatty acid-binding protein and gut permeability responses to exercise. Eur J Appl Physiol. 2017;117:931–41.
CAS
PubMed
PubMed Central
Google Scholar
March DS, Jones AW, Thatcher R, Davison G. The effect of bovine colostrum supplementation on intestinal injury and circulating intestinal bacterial DNA following exercise in the heat. Eur J Nutr. 2019;58:1441–51.
PubMed
Google Scholar
McKenna Z, Berkemeier Q, Naylor A, Kleint A, Gorini F, Ng J, et al. Bovine colostrum supplementation does not affect plasma I-FABP concentrations following exercise in a hot and humid environment. Eur J Appl Physiol. 2017;117:2561–7.
CAS
PubMed
Google Scholar
Morrison SA, Cheung SS, Cotter JD. Bovine colostrum, training status, and gastrointestinal permeability during exercise in the heat: a placebo-controlled double-blind study. Appl Physiol Nutr Metab. 2014;39:1070–82.
CAS
PubMed
Google Scholar
Pugh J, Sage S, Hutson M, Doran DA, Fleming SC, Highton J, et al. Glutamine supplementation reduces markers of intestinal permeability during running in the heat in a dose-dependent manner. Eur J Appl Physiol. 2017;117:2569–77.
CAS
PubMed
PubMed Central
Google Scholar
Pugh JN, Impey SG, Doran DA, Fleming SC, Morton JP, Close GL. Acute high-intensity interval running increases markers of gastrointestinal damage and permeability but not gastrointestinal symptoms. Appl Physiol Nutr Metab. 2017;42:941–7.
CAS
PubMed
Google Scholar
Snipe RMJ, Khoo A, Kitic CM, Gibson PR, Costa RJS. Carbohydrate and protein intake during exertional heat stress ameliorates intestinal epithelial injury and small intestine permeability. Appl Physiol Nutr Metab. 2017a;42:1283–92.
CAS
PubMed
Google Scholar
Snipe RMJ, Khoo A, Kitic CM, Gibson PR, Costa RJS. The impact of exertional-heat stress on gastrointestinal integrity, gastrointestinal symptoms, systemic endotoxin and cytokine profile. Eur J Appl Physiol. 2018a;118:389–400.
CAS
PubMed
Google Scholar
Snipe RMJ, Khoo A, Kitic CM, Gibson PR, Costa RJS. The impact of mild heat stress during prolonged running on gastrointestinal integrity, gastrointestinal symptoms, systemic endotoxin and cytokine profiles. Int J Sports Med. 2018b;39:255–63.
CAS
Google Scholar
Snipe RMJ, Costa RJS. Does the temperature of water ingested during exertional-heat stress influence gastrointestinal injury, symptoms, and systemic inflammatory profile? J Sci Med Sport. 2018;21:771–6.
PubMed
Google Scholar
Szymanski MC, Gillum TL, Gould LM, Morin DS, Kuennen MR. Short-term dietary curcumin supplementation reduces gastrointestinal barrier damage and physiological strain responses during exertional heat stress. J Appl Physiol. 2018;124:330–40.
CAS
PubMed
Google Scholar
Van Wijck K, Wijnands KAP, Meesters DM, Boonen B, Van Loon LJC, Buurman WA, et al. L-citrulline improves splanchnic perfusion and reduces gut injury during exercise. Med Sci Sports Exerc. 2014;46:2039–46.
PubMed
Google Scholar
Buchman AL, O’Brien W, Ou CN, Rognerud C, Alvarez M, Dennis K, et al. The effect of arginine or glycine supplementation on gastrointestinal function, muscle injury, serum amino acid concentrations and performance during a marathon run. Int J Sports Med. 1999;20:315–21.
CAS
PubMed
Google Scholar
Davison G, Marchbank T, March DS, Thatcher R, Playford RJ. Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers. Am J Clin Nutr. 2016;104:526–36.
CAS
PubMed
Google Scholar
Lambert GP, Lang J, Bull A, Pfeifer PC, Eckerson J, Moore C, et al. Fluid restriction during running increases GI permeability. Int J Sports Med. 2008;29:194–8.
CAS
PubMed
Google Scholar
van Nieuwenhoven MA, Brouns F, Brummer RJM. Gastrointestinal profile of symptomatic athletes at rest and during physical exercise. Eur J Appl Physiol. 2004;91:429–34.
PubMed
Google Scholar
Zuhl MN, Lanphere KR, Kravitz L, Mermier CM, Schneider S, Dokladny K, et al. Effects of oral glutamine supplementation on exercise-induced gastrointestinal permeability and tight junction protein expression. J Appl Physiol. 2014;116:183–91.
CAS
PubMed
Google Scholar
Zuhl M, Dokladny K, Mermier C, Schneider S, Salgado R, Moseley P. The effects of acute oral glutamine supplementation on exercise-induced gastrointestinal permeability and heat shock protein expression in peripheral blood mononuclear cells. Cell Stress Chaperones. 2015;20:85–93.
CAS
PubMed
Google Scholar
JanssenDuijghuijsen LM, Keijer J, Mensink M, Lenaerts K, Ridder L, Nierkens S, et al. Adaptation of exercise-induced stress in well-trained healthy young men. Exp Physiol. 2017;102:86–99.
CAS
PubMed
Google Scholar
Ashton T, Young IS, Davison GW, Rowlands CC, McEneny J, Van Blerk C, et al. Exercise-induced endotoxemia: the effect of ascorbic acid supplementation. Free Radic Biol Med. 2003;35:284–91.
CAS
PubMed
Google Scholar
Ryan AJ, Chang RT, Gisolfi CV. Gastrointestinal permeability following aspirin intake and prolonged running. Med Sci Sports Exerc. 1996;28:698–705.
CAS
PubMed
Google Scholar
Shing CM, Peake JM, Lim CL, Briskey D, Walsh NP, Fortes MB, et al. Effects of probiotics supplementation on gastrointestinal permeability, inflammation and exercise performance in the heat. Eur J Appl Physiol. 2014;114:93–103.
PubMed
Google Scholar
Yeh YJ, Law LYL, Lim CL. Gastrointestinal response and endotoxemia during intense exercise in hot and cool environments. Eur J Appl Physiol. 2013;113:1575–83.
CAS
PubMed
Google Scholar
Snipe RMJ, Khoo A, Kitic CM, Gibson PR, Costa RJS. Carbohydrate and protein intake during exertional-heat stress ameliorates intestinal epithelial injury and small intestine permeability. Appl Physiol Nutr Metab. 2017b;42:1–41.
Google Scholar
Lamprecht M, Bogner S, Schippinger G, Steinbauer K, Fankhauser F, Hallstroem S, et al. Probiotic supplementation affects markers of intestinal barrier, oxidation, and inflammation in trained men; a randomized, double-blinded, placebo-controlled trial. J Int Soc Sports Nutr. 2012;9:1.
Google Scholar
Barker N. Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration. Nat Rev Mol Cell Biol. 2014;15:19–33.
CAS
PubMed
Google Scholar
Grootjans J, Hodin CM, De Haan J, Derikx JPM, Rouschop KMA, Verheyen FK, et al. Level of activation of the unfolded protein response correlates with Paneth cell apoptosis in human small intestine exposed to ischemia/reperfusion. Gastroenterology. 2011;140:529.e3-539.e3.
Google Scholar
Thomas DT, Erdman KA, Burke LM. Nutrition and athletic performance. J Acad Nutr Diet. 2016;116:501–28.
PubMed
Google Scholar
Addobbati R, Pascolo L, Di TN, Sebastiani GB, Martellossi S, Not T. Influence of urine volume on the assessment of intestinal permeability in affected children by multiple sugar probes. Clin Chem Lab Med. 2014;52:227–35.
CAS
PubMed
Google Scholar
van Wijck K, van Eijk HMH. Polyethylene glycol versus dual sugar assay for gastrointestinal permeability analysis : is it time to choose? Clin Exp Gastroenterol. 2012;13950.
Halme L, Turunen U, Tuominen J, Forsström T, Turpeinen U. Comparison of iohexol and lactulose-mannitol tests as markers of disease activity in patients with inflammatory bowel disease. Scand J Clin Lab Investig. 2000;60:695–701.
CAS
Google Scholar
Sequeira IR, Lentle RG, Kruger MC, Hurst RD. Differential trafficking of saccharidic probes following aspirin in clinical tests of intestinal permeability in young healthy women. Clin Exp Pharmacol Physiol. 2014;41:107–17.
CAS
PubMed
Google Scholar
Roger T, Heumann D. Initial responses to endotoxins and Gram-negative bacteria. Clin Chim Acta. 2002;323:59–72.
PubMed
Google Scholar
Schwellnus M, Soligard T, Alonso JM, Bahr R, Clarsen B, Dijkstra HP, et al. How much is too much? (Part 2) International Olympic Committee consensus statement on load in sport and risk of illness. Br J Sports Med. 2016;50:1043–52.
PubMed
PubMed Central
Google Scholar
Phua LC, Wilder-Smith CH, Tan YM, Gopalakrishnan T, Wong RK, Li X, et al. Gastrointestinal symptoms and altered intestinal permeability induced by combat training are associated with distinct metabotypic changes. J Proteome Res. 2015;14:4734–42.
CAS
PubMed
Google Scholar