Innovations in hepatitis C virus (HCV) therapy included in traditional comparative evaluations focus on sustained virologic response (SVR) without addressing challenges patients report beyond virologic cure. This study aims to evaluate the cost-effectiveness of HCV drug therapy with a patient-centered approach.
An individual-based Markov model was constructed using guidance from a stakeholder advisory board (SAB), a patient Delphi panel, and published literature to evaluate direct-acting antivirals (DAAs) compared to no treatment. The United States (US) health sector and societal perspectives were considered for 10- and 20-year time horizons. Inputs for treatment costs and effectiveness reflect a generic regimen. Indirect costs used for the societal model included estimates from self-reported productivity in a matched-control sample. Beyond the traditional quality-adjusted life-year (QALY) health outcome, this study included two novel measures developed from the Delphi panel and SAB: infected life-years and workdays missed. All costs were measured in 2018 US dollars.
Health sector costs and QALYs were higher in the treatment group in both 10- and 20-year models. Total infected life-years and workdays missed were reduced in the treatment group for both models. When costs of absenteeism, presenteeism, and patient/caregiver time were included, the DAA intervention was cost-saving at both 10 and 20 years. Health sector results were sensitive to drug costs and utility estimates for post-SVR health states. Societal results were sensitive to presenteeism estimates and drug costs.
Treatment was cost-effective from a health sector perspective and cost-saving when including non-health costs such as patient/caregiver time and productivity.
A Patient-Centered Legislative Dilemma
In the United States (US), the Patient-Centered Outcomes Research Institute (PCORI) supports patient-centered comparative effectiveness research (CER) along with other patient-centered research . Created with the passage of the Patient Protection and Affordable Care Act in 2010, this relatively new institute has allocated over $2 billion in research projects to fulfill its mission of producing and promoting evidence-based information that comes from research guided by patients . However, the Affordable Care Act specifically limited PCORI when supporting cost-effectiveness research that uses a quality-adjusted life-year (QALY) to limit access to treatment through the following language in the statute:
“The Patient-Centered Outcomes Research Institute established under section 1181(b)(1) shall not develop or employ a dollars-per-quality adjusted life year (or similar measure that discounts the value of a life because of an individual’s disability) as a threshold to establish what type of health care is cost effective or recommended” .
Leading cost-effectiveness experts have consistently recommended all cost-effectiveness analyses (CEAs) report an incremental cost-effectiveness ratio (ICER), calculated as the difference in costs in the numerator and the difference in effectiveness (measured in QALYs) in the denominator. However, interpretation of the statute has essentially banned PCORI from funding CEAs, because of the use of the QALY [4,5,6]. For health economists, when a leading funder of patient-centered outcomes research decided not to support CEAs, it limited where their study proposals could be submitted. While PCORI became a catalyst for new CER, an unintended consequence of the QALY prohibition was the establishment of a solid line of demarcation between patient-centricity and CEA.
Cost Effectiveness in Hepatitis C and the Potential for Patient Engagement
The cost effectiveness of medications used to treat chronic hepatitis C virus (HCV) patients in the US has been studied extensively with a variety of clinical, economic model, and real-world data investigations [7, 8]. Effectiveness outcomes in economic models for HCV treatments have traditionally focused on survival, reducing all-cause and liver-related mortality, and morbidity through health-related quality-of-life (HRQoL) assessments, leading to utility adjustments for estimating QALYs gained . The Institute for Clinical and Economic Review, an organization in the US that conducts value assessments, evaluated direct-acting antivirals (DAAs) in 2015 in a way that mirrored other traditional CEAs in HCV, with a cost-per-QALY result with no patient input . Outside of the US, the German Institute for Quality and Efficiency in Health Care (IQWiG) developed a value assessment of HCV treatment options informed by patient preferences, leading to a proposed “efficiency frontier” to inform pricing without reporting a cost per QALY [10, 11]. The IQWiG model identified eight clinical attributes and used discrete choice experiments for weighting them in a final model . While the IQWiG pilot demonstrated a novel approach to CEA without the QALY, it did not appear that the researchers systematically engaged HCV patients throughout the process or partnered with patients to improve study methodology or dissemination of results [12, 13]. Though nothing restricts health economists from incorporating the voice of HCV patients throughout their work, the number of HCV-specific CEAs that reflect value from the patient’s perspective has been limited . Here, we report the results of an economic model for HCV treatments guided by a patient-centered advisory board and informed by a patient-only Delphi panel to capture model variables and outcomes important to patients .
Patient-Centered Model Overview
The Value in Hepatitis C Virus Treatment Patient-Centered Model was developed by following the 10-Step Framework for Continuous Patient Engagement . An 11-member, patient-centered, stakeholder advisory board (SAB) including four HCV patients, three infectious disease specialists, one general practitioner, two pharmacists, and a national patient advocacy organization representative was formed . Health economists typically solicit clinical experts. This project incorporated input from five patient experts throughout the study. The SAB reviewed components of the model, including structure, inputs, outcomes, and the presentation of results. In-person meetings and conference calls were scheduled throughout the project for iterative feedback and general qualitative discussion. Formal voting was not requested if there was general consensus on a topic. The SAB helped inform the methods of the Delphi process, previously published, and the following economic model .
An individual-level Markov model was used to simulate the natural history and progression of liver disease among individuals infected with chronic HCV and compare outcomes of recommended treatment strategies similar to previously published research [16,17,18,19]. The target population reflected the age and disease severity of patients diagnosed with HCV who were likely to be treated in the outpatient setting with a medication regimen [20,21,22]. The cycle length for each period was 1 year, for a total of 10 and 20 cycles, with an annual discount rate of 3% used for all costs and effects . The 10- and 20-year time horizons were both reported to demonstrate the impact of time on model outcomes. A generic treatment strategy using a DAA regimen was based on clinical guidelines developed by the American Association for the Study of Liver Diseases (AASLD) in partnership with the Infectious Diseases Society of America (IDSA) and the patient-only Delphi panel .
Disease Progression Probability
Progression of disease was scored using advancing fibrosis stages categorized by METAVIR . Health states representing the natural history of liver disease associated with chronic HCV infection and progression probabilities of transitioning among disease stages from previous studies were utilized [18, 26,27,28]. Patients entered the model at different fibrosis stages based on estimates representative of the US population used in previous studies . Probability of DAA treatment success was estimated at 90% (82–98%) based on published systematic reviews [29, 30]. Patients reaching sustained virologic response (SVR) after treatment entered post-SVR health states with reduced progression rates estimated from histologic benefits previously reported [18, 31]. Patients who failed to reach SVR entered a natural progression process with baseline fibrosis staging severity ranging between METAVIR F0 and F4 . Patients in the F0 state who failed to reach SVR or were untreated were able to spontaneously achieve SVR and enter the post-SVR health states . From the post-SVR state, reinfection resulted in a set of advanced progression states, with fibrosis progression estimated at twice the natural history progression, with no opportunity for retreatment [27, 32, 33]. Risk of reinfection was applied equally to all post-SVR states .
The costs evaluated in this study included both US health system and societal perspectives as shown in the impact inventory (Table 1). Drug costs in the first year of therapy for DAAs were estimated based off of the VA Federal Supply Schedule (VAFSS) listed for each treatment regimen for the duration of therapy for the base case . Annualized maintenance costs, patient/caregiver time costs, absenteeism, and presenteeism costs were derived from previous studies of chronic HCV and adjusted to 2018 US dollars [18, 19, 36, 37]. Patients achieving SVR were assigned lower costs for absenteeism and presenteeism, based on evidence of an HCV population compared to matched controls . Patients who did not reach SVR in year 1 entered the natural progression model of liver disease, incurring annual maintenance costs associated with each stage of advanced disease. Patients reaching the transplant stage only stayed in the ‘transplant’ health state for 1 year, immediately progressing to the post-transplant state in the following cycle .
Health-state utility estimates were found from multiple studies, including a meta-analysis of Short Form-36 scores in HCV patients that were transformed into utility weights using multiple methods [39, 40]. These estimates were used to calculate QALYs as a model outcome in accordance with recommendations . Beyond the traditional QALY health outcome, this study included two novel outcome measures developed from the HCV patient Delphi panel and reviewed by our SAB. Patients identified “fear of harming others” as an important problem caused by having HCV in addition to the consideration of indirect costs such as “financial issues” or “impact on work or career.” This patient input was used to develop two measurable health outcomes in our model: infected life-years (ILYs) and workdays missed. In order to calculate ILYs for each hypothetical patient in the model, a tracker was developed to count the cycles the patient spent in an “infected” health state (i.e., natural history health states and advanced progression health states). The ILY tracker did not include potential years with the disease prior to entering the model. The workdays missed estimate was calculated for each cycle from absenteeism rates previously reported for HCV patients (5.03% annually) compared to matched controls (2.82% annually) multiplied by 250 days in the working calendar (5 days per week, 50 weeks per year) . Patients in active HCV health states experienced these additional workdays missed. Since negative ILYs and workdays missed were beneficial, for consistent comparison, these outcomes were multiplied by − 1 to convert the incremental comparison to a cost per outcome avoided.
The health state model was developed using TreeAge Pro® based on the structure in Fig. 1 and a detailed Markov process outlined in supplementary Figure 2 (see the supplementary electronic material) . Both US health sector and societal perspective base cases were estimated in accordance with the recommendations and based on feedback from the SAB to account for patient-informed outcomes . The SAB and coauthors reviewed the model structure and results for face validity and provided input during model development . Additionally, model structure, data inputs, and coding logic were presented by the lead author (TJM) and evaluated by two co-authors (JFS, EO) to improve internal validity of the calculations in TreeAge Pro®. To avoid potential double counting of productivity costs (absenteeism and presenteeism) in the numerator and denominator of the societal perspective, workdays missed were only used as potential benefits in the health sector model. Inputs used for each base case were derived from published literature, and are listed in Table 2. Additional one-way sensitivity analyses were conducted based on high-low estimates and a probabilistic sensitivity analysis with 1000 repetitions. The assigned probability distributions for the model parameters are listed in Table 2 .
Stakeholder Advisory Board Meetings
A total of 11 SAB meetings were convened from 2017–2019, spanning different stages of the project, with three meetings focused on economic model development. Meeting agendas and minutes were recorded and shared with the group. The reference-case results were presented to the committee and discussed, but no formal vote was taken for a preferred outcome. The SAB members believed that multiple outcomes might be used by different audiences and that summarizing in a patient-friendly format (such as a blog post) was appropriate.
Health Sector Perspective
When comparing treated patients to those who did not receive DAAs, treatment resulted in greater direct costs (difference $25,078), more QALYs (difference 0.63), fewer ILYs (difference − 7.24), and fewer workdays missed (difference − 35.05) in the 10-year health sector perspective. When comparing treated patients to those who did not receive DAAs, over a 20-year time horizon, treatment resulted in greater direct costs (difference $8077), more QALYs (difference 1.66), fewer ILYs (difference − 13.11), and fewer workdays missed (difference − 63.85). The potential ICERs over a 20-year time horizon for treatment were $4866/QALY gained, $616/ILY, and $126/workdays missed (Table 3).
From a societal perspective, 10- and 20-year scenarios demonstrated that treating patients with DAAs reduced total costs by $18,921 and $54,261, respectively (Table 3). Treatment dominated the ‘no treatment’ arm at any willingness-to-pay (WTP) threshold because it produced greater health outcomes (QALY and ILY) at a lower cost.
Overall, the sensitivity analyses demonstrated the importance of specific variable inputs in each perspective. While certain inputs created wider variation than others (median drug costs, utility estimates in healthier states, costs of presenteeism and absenteeism in the societal perspective, etc.), the models were robust at a $100,000/QALY WTP threshold.
Results of the parameter adjustments are presented in tornado diagrams for health sector and societal models for 10- and 20-year time horizons (supplementary Figures 2–5; see the electronic supplementary material). The results of the second-order probabilistic sensitivity analysis are presented using scatter plots of cost–effect pairs and cost-effectiveness acceptability curves (CEAC) with increasing WTP in supplementary Figures 6–13 (see the electronic supplementary material).
While the US has no explicit WTP threshold for cost effectiveness, the use of DAAs in our model resulted in better outcomes at a cost below historic thresholds used for this type of analysis (e.g., $50,000–$150,000/QALY) [43,44,45]. When considering societal perspective costs, including patient/caregiver time and productivity losses through patient absenteeism and presenteeism, DAAs were cost-saving in both 10- and 20-year scenarios. Treatment also leads to a reduction in number of years living with the virus and the number of workdays missed. Our 20-year health sector ICER of $4866/QALY outcome was generally more favorable than the ICERs calculated with comparable models, but many models report recommendations that result in the same decision to treat [18, 46,47,48].
To our knowledge, this is the first patient-centered economic model developed for HCV treatments utilizing a patient-centered SAB along with a patient Delphi to guide research decisions and methods chosen. Since the advent of DAAs, traditional economic models using a cost/QALY endpoint have demonstrated the cost effectiveness of these therapies using a variety of methods, populations, perspectives, treatments, and comparators [8, 49]. Despite all of the research variations, economic modelers have not incorporated patients as stakeholders in the model-development process, potentially limiting its use as CER as defined by the Institute of Medicine . Furthermore, by using a systematic approach for continuous patient engagement, we were able to capture a perspective of “value” for treatment decision-making that was different to what has been identified previously by clinicians, researchers, and payers [12, 13].
The use of the QALY as a primary health outcome measure in economic models has been a standard of practice since the first Panel on Cost-Effectiveness in Health and Medicine convened in the early 1990s . Health economists agree that this measure’s advantages outweigh some of its limitations, and leading experts continue to recommend a cost/QALY outcome as the “starting point” to inform value decisions . This recommendation does not preclude investigators from exploring new ways to analyze and disseminate the results of CEA. In fact, there is a great deal of discussion regarding alternatives to this single endpoint approach [52,53,54]. We argue, thanks to suggestions from individuals with lived experience with HCV, CEAs for interventions in HCV should go beyond this starting point by including multiple denominators for comparison. We propose two new denominators that are meant to enhance the value assessment discussion for this clinical scenario.
In the US, the predominance of employer-sponsored health plans adds nuance to the discussion around value and the determination of a WTP threshold . Economic models that only report a QALY-based outcome may not fully resonate with an employer’s senior leadership team while making health plan decisions. The results of the patient-centered CEA reported workdays missed in the treatment and no treatment groups in addition to conducting the analysis from a societal perspective that captured productivity cost estimates. Comparing the incremental costs of treatment with the number of workdays a cured patient can potentially gain back may provide greater clarity, as compared to interpreting cost/QALY, around the opportunity costs involved that would directly impact the employer. These results were understood by the SAB, but whether or not formulary decision-makers within payer organizations would find this information useful was not addressed. A meaningful next step would be to convene experts within managed care organizations and solicit feedback on the model results. Patient engagement within health technology assessment conducted in countries with single government payer systems also benefit by capturing more components of value defined by the patient population coverage determinations’ impact.
The ILY outcome was a result of conducting this research within an infectious disease area, but is likely not of interest for diseases that are not communicable. Continuous patient engagement requires talking with patients early and often throughout the research process . This suggests that starting with a blank slate is not only encouraged, but necessary to reduce investigator-initiated bias. Systematically capturing patient input through advisory boards, focus groups, and semi-structured interviews can be costly and time-consuming, but these steps are paramount to patient-centered CEA development. However, which engagement method is most appropriate to guide health economists is unknown. Researching patient engagement with different types of patients informing different CEA approaches (observational studies, models, etc.) may help identify best practices moving forward.
Beyond cost effectiveness, other organizations are considering systematically including patient perspectives throughout guidelines and other processes. For example, the Food and Drug Administration has begun using the term “patient-focused drug development” to describe new initiatives to engage patients and patient advocacy organizations to capture patient perspectives on disease severity or potential unmet needs in a disease area that may benefit the drug review process . These initiatives may provide a new reference for regulatory decisions, but additional research may be warranted to evaluate potential unintended consequences of a shift towards patient-centeredness .
Our study has several limitations that should be considered when interpreting the results. First, both the initial medication treatment cost and effectiveness inputs for a patient entering the model were simplified to reflect an average patient case. This was determined in consultation with our SAB, which was less concerned with the specific treatment regimen because of the availability of multiple once-a-day DAAs with similar rates of SVR. Notable comments from the SAB include statements such as, “Patients do not use terms like ‘quality-of-life’ but they may infer it” and “patients should be treated holistically.” While we incorporated different adjustments and assumptions through sensitivity analyses, special populations (such as incarcerated patients) which constitute a non-negligible proportion of HCV patients may need to be considered separately. Our supplemental file aims to provide complete transparency to allow other researchers to replicate our model and make any necessary input adjustments to test if this approach would yield similar results in unique populations.
Additionally, data on time and productivity costs for HCV patients were sparse compared to the data available for direct health costs that are frequently used in CEAs for these drugs. We used published estimates for time and productivity (absenteeism and presenteeism) costs from a study of 306 HCV patients compared with propensity matched controls using the Work Productivity and Activity Impairment questionnaire [36, 37]. This self-reported time and productivity loss may overestimate actual productivity losses . The patient and caregiver time costs were combined to be consistent with the way in which the original study collected this information and the way results were reported in their final regression model . The time costs estimates used in our analysis were from a study of 738 HCV outpatients in Canada, potentially limiting the generalizability to time costs in the US despite our conversion and inflation adjustments. Additionally, absenteeism and presenteeism estimates were based on a US survey that may not be completely representative of marginalized populations or the incarcerated population. In our one-way sensitivity analyses, we used zero as the lower limit for all of these estimates and found that the 10- and 20-year models were sensitive to the inputs for presenteeism in the HCV and non-HCV groups. Our model was not sensitive to age at model initiation, but more detailed scenario analyses for different age cohorts may be important when considering many societal perspective items or potential spillover effects on caregivers.
Given the approach of utilizing a patient-centered SAB along with a patient Delphi to guide research decisions has not been widely implemented in economic modeling, we have little evidence to compare whether our advisor recommendations would have differed greatly with a larger board or completely different set of advisors. Patients selected for the SAB and Delphi were considered experts based on their lived experience, and their input was treated the same as any other clinical or methodological input offered by other advisors.
In terms of cost-effectiveness, treatment of HCV with highly effective DAAs improves disease burden and outcomes identified by patients. Using a patient-centered approach, additional costs and outcomes meaningful to HCV patients were identified and then implemented, specifically cost/ILY and cost/workdays missed ICER estimates. Treatment was cost effective from a health sector perspective and cost-saving when including non-health costs such as patient/caregiver time and productivity.
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The authors would like to thank the study advisory board members for their contribution to the concept, design, and interpretation of this study.
The Stakeholder Advisory Board described in this manuscript was initiated with a research grant from the Patient-Centered Outcomes Research Institute (7709720-A).
Data availability statement
All input data for the decision analytical model are available within the article and the electronic supplementary material. The decision analytical model is available from the corresponding author on reasonable request.
Conflict of interest
TJM reports consultant fees from G&W Labs, BMS, PhRMA, and NHC, all unrelated to this research. EO reports grants from Bayer Healthcare Pharmaceuticals, Inc. and from Pfizer, personal fees from Novo Nordisk, unrelated to this work. EMP is an employee of the National Health Council, which receives membership dues and sponsorship funding from a wide range of organizations. For the full list, please see http://www.nhcouncil.org. JFS reports grants from Novartis Pharmaceuticals, Takeda Pharmaceuticals, the PhRMA Foundation, and PhRMA unrelated to this work, as well as teaching honorarium from Pfizer. SK reports grants from Gilead Sciences, Merck, and Arbutus Pharma. CDM reports grants from Merck and consulting fees from Bayer, Boehringer-Ingelheim, Illumina, Janssen, Merck, Pfizer, Regeneron, and Sanofi.
Electronic supplementary material
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Mattingly, T.J., Slejko, J.F., Onukwugha, E. et al. Value in Hepatitis C Virus Treatment: A Patient-Centered Cost-Effectiveness Analysis. PharmacoEconomics 38, 233–242 (2020). https://doi.org/10.1007/s40273-019-00864-8